LncRNA TUG1 promotes Ewing's sarcoma cell proliferation, migration, and invasion via the miR-199a-3p-MSI2 signaling pathway

Hu, Li; Huang, Fang; Liu, Xuqiang; Liu, Hu-Cheng; Dai, Min; Zeng, Jin

doi:10.4149/neo_2021_201110n1198

Cited by 11 publications

(9 citation statements)

References 36 publications

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“…The large number of lncRNAs produced by human cells contributes an important role to various biological processes, including genome expression and cell differentiation [ 25 ]. Recent studies suggest that an abnormal expression of lncRNA may play a role in the progression and development of cancer [ 26 , 27 ]. However, there is currently little research investigating cuproptosis-associated lncRNAs.…”

Section: Discussionmentioning

confidence: 99%

A Newly Established Cuproptosis-Associated Long Non-Coding RNA Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Soft Tissue Sarcoma

Han

Liu

et al. 2022

Journal of Oncology

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Cuproptosis, a new type of programmed cell death, is involved in the development and progression of malignancies. The study of cuproptosis-associated long non-coding RNAs (lncRNAs) in soft tissue sarcomas (STSs) is however limited. There is also uncertainty regarding the prognostic accuracy of cuproptosis-associated lncRNAs in STSs and their relationship to the tumor immune microenvironment. The aim of this study was to determine the prognostic significance of cuprotosis-associated lncRNAs in STSs and their relationship to the tumor immune microenvironment. Transcriptomic and clinical data from patients with STSs were obtained through The Cancer Genome Atlas (TCGA). Overall, 259 patients were randomly allocated to a training group or a testing group. In the training group, a cuproptosis-associated lncRNA signature was constructed, and the signature was verified in the testing group. On the basis of risk scores and clinical features, we later developed a hybrid nomogram. We also performed functional and tumor immune microenvironment analysis based on the cuproptosis-associated lncRNA signature. A signature of 5 cuproptosis-associated lncRNAs was created. Based on this signature, we categorized STS patients into high-risk and low-risk groups. The study showed that patients at high risk had a worse prognosis than those at low risk. A nomogram was then constructed combining clinical characteristics with the risk scores, and it was shown to have credible predictive power. Functional enrichment and tumor immune microenvironmental analyses showed that high-risk STSs tend to be immunologically sensitive tumors. In our study, we found a cuproptosis-associated lncRNAs signature, which serves as an independent prognostic indicator. Cuproptosis-associated lncRNAs may play a role in the tumor immune microenvironment, which might be a therapeutic target for patients with STSs.

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Section: Discussionmentioning

confidence: 99%

A Newly Established Cuproptosis-Associated Long Non-Coding RNA Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Soft Tissue Sarcoma

Han

Liu

et al. 2022

Journal of Oncology

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“…In Ewing’s sarcoma tissues and cells, the down-regulation of lncRNA TUG1 (taurine up-regulated gene 1) or overexpression of miR-199a-3p could inhibit cell proliferation, migration, and invasion. TUG1, as a ceRNA, regulated the expression of MSI2 (musashi2) by sponging miR-199a-3p, thereby promoting the malignant phenotype of Ewing’s sarcoma cells [ 88 ].…”

Section: Resultsmentioning

confidence: 99%

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Wei

Chai

et al. 2022

IJMS

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Lung cancer is the leading cause of cancer death worldwide. miR-199a, which has two mature molecules: miR-199a-3p and miR-199a-5p, plays an important biological role in the genesis and development of tumors. We collected recent research results on lung cancer and miR-199a from Google Scholar and PubMed databases. The biological functions of miR-199a in lung cancer are reviewed in detail, and its potential roles in lung cancer diagnosis and treatment are discussed. With miR-199a as the core point and a divergence outward, the interplay between miR-199a and other ncRNAs is reviewed, and a regulatory network covering various cancers is depicted, which can help us to better understand the mechanism of cancer occurrence and provide a means for developing novel therapeutic strategies. In addition, the current methods of diagnosis and treatment of lung cancer are reviewed. Finally, a conclusion was drawn: miR-199a inhibits the development of lung cancer, especially by inhibiting the proliferation, infiltration, and migration of lung cancer cells, inhibiting tumor angiogenesis, increasing the apoptosis of lung cancer cells, and affecting the drug resistance of lung cancer cells. This review aims to provide new insights into lung cancer therapy and prevention.

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“…Nowadays, the role of lncRNAs is creating emerging concern in biological processes such as cells proliferation and differentiation 29 . Recent studies have found that dysregulation of lncRNAs may lead to tumorigenesis and progression 30,31 . However, little research was conducted on lncRNA associated with cuproptosis.…”

Section: Discussionmentioning

confidence: 99%

A New Establishment of Cuproptosis-Related Long Non-Coding RNA Signature to Predict Prognosis in Head and Neck Squamous cell Carcinomas

wang

Gao

Xue

et al. 2022

Preprint

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Background Cuproptosis is a novel type of programmed cell death which plays an important role in the development and progression of cancer. However, there is a limited amount of research on cuproptosis-associated long non-coding RNAs (lncRNAs) in head and neck squamous cell carcinomas (HNSCCs). This study aimed to investigate the predictive value of cuproptosis-related lncRNA signature for HNSCC prognosis. Method Transcriptomic and clinical data of HNSCC patients were obtained from the Cancer Genome Atlas (TCGA). We established a cuproptosis-related lncRNA signature and then constructed a hybrid nomogram based on risk scores and clinical factors. We also performed differential expression genes (DEGs) function, immune cells infiltration, immune checkpoint analysis based on cuproptosis-associated lncRNA signature. Results A signature of 27 cuproptosis-related lncRNAs was performed and the prognosis of patients at high risk is worse compared with patients at low risk based on above signature. A nomogram which integrated risk scores and clinical features also showed favorable predictive power. Furthermore, DEGs in high or low risk group were mainly enriched in immune-related pathways. Anti-tumor immune cells and immune checkpoints were mainly enriched in low risk group compared with high risk group. Conclusion Cuproptosis-related lncRNAs could be regarded as independent indicators for HNSCC prognosis which might be effective targets for HNSCC therapy.

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LncRNA TUG1 promotes Ewing's sarcoma cell proliferation, migration, and invasion via the miR-199a-3p-MSI2 signaling pathway

Cited by 11 publications

References 36 publications

A Newly Established Cuproptosis-Associated Long Non-Coding RNA Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Soft Tissue Sarcoma

A Newly Established Cuproptosis-Associated Long Non-Coding RNA Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Soft Tissue Sarcoma

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

A New Establishment of Cuproptosis-Related Long Non-Coding RNA Signature to Predict Prognosis in Head and Neck Squamous cell Carcinomas

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