LncRNA-MALAT1-mediated Axl promotes cell invasion and migration in human neuroblastoma

Bi, Shao‐Jie; Wang, Chunyan; Li, Yixin; Zhang, Wei; Zhang, Juan; Lv, Zhaopeng; Wang, Junxia

doi:10.1177/1010428317699796

Cited by 27 publications

(17 citation statements)

References 24 publications

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“…On the other hand, several studies showed that the expression of MALAT1 is downregulated in glioma [27], colorectal cancer [28], and breast cancer [29,30]. Previous in vitro and xenograft studies demonstrated that MALAT1 promotes cell proliferation, migration, tumor growth, metastasis, and chemoresistance [31,32,33,34,35,36,37]. In contrast, other studies reported that MALAT1 inhibits cell proliferation, tumor growth, invasion, and epithelial-mesenchymal transition (EMT) [27,28,30,38,39,40].…”

Section: Is Malat1 a Metastasis Promoter Or A Metastasis Suppressor?mentioning

confidence: 99%

New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis

Sun

2019

Cancers

237

171

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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to regulate alternative pre-mRNA splicing and gene expression. However, Malat1 knockout mice develop and grow normally, and do not show alterations in alternative splicing. While MALAT1 was originally described as a prognostic marker of lung cancer metastasis, emerging evidence has linked this lncRNA to other cancers, such as breast cancer, prostate cancer, pancreatic cancer, glioma, and leukemia. The role described for MALAT1 is dependent on the cancer types and the experimental model systems. Notably, different or opposite phenotypes resulting from different strategies for inactivating MALAT1 have been observed, which led to distinct models for MALAT1′s functions and mechanisms of action in cancer and metastasis. In this review, we reflect on different experimental strategies used to study MALAT1′s functions, and discuss the current mechanistic models of this highly abundant and conserved lncRNA.

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Section: Is Malat1 a Metastasis Promoter Or A Metastasis Suppressor?mentioning

confidence: 99%

New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis

Sun

2019

Cancers

237

171

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“…MALAT1 regulates endothelial cell function and vessel growth (Michalik et al, ). MALAT1 promotes cell migration and invasion by upregulating the gene expression of latent transforming growth factor beta binding protein 3 (LTBP3) and Axl (Bi et al, ; Hou et al, 2017). MALAT1 represses the expression of E‐cadherin by associating with suppressor of zeste 12 (suz12), thereby regulating EMT (Fan et al, ).…”

Section: Physiopathological Role Of Malat1mentioning

confidence: 99%

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

Chen

Huang

et al. 2018

Journal Cellular Physiology

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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA whose transcript is around 8 kb in length. As an important stress response molecule, MALAT1 can be expressed differently under stress conditions, such as hypoxia, high glucose, hydrogen peroxide, ultraviolet irradiation, infection, and chemical stimulation. MALAT1 is involved in regulating multiple cell behaviors, such as proliferation, apoptosis, differentiation, migration, epithelial-mesenchymal transition, autophagy, and morphological maintenance. Extensive evidence show that MALAT1 plays critical roles in the physiopathological process of embryo implantation, angiogenesis, tissue inflammation, tumor progression, liver fibrosis, cardiovascular remodeling, and diabetes progression by regulating gene transcription, forming RNA-protein complexes with proteins as a structural component, regulating protein activity, assisting protein localization, mediating epigenetic changes, or by acting as a competing endogenous RNA. Furthermore, MALAT1 can affect the sensitivity of chemotherapy and radiotherapy; therefore, it could be used as a potential drug target for chemotherapy and radiotherapy sensitization. The levels of MALAT1 are reported to be overexpressed in most tumor tissues or sera, and the expression levels of MALAT1 often affect the tumor size, stage, lymph node metastasis, and distant invasion. Therefore, MALAT1 can be used as a biomarker for early diagnosis, severity assessment, or prognostic assessment. This review outlines the current understanding of the biological role and function of MALAT1. In the meantime, we have summarized the mechanisms involved in the reulation of MALAT1 expression and the mechanisms by which MALAT1 regulates the physiological and pathological processes.

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“…LncRNAs are involved in many biological processes, with LncRNA-MALAT1 and GAS5 being reported to mediate cell invasion, migration, and apoptosis in human neuroblastoma [ 34 , 35 ]. The lnc-LAMC2–1:1 polymorphism is located in the LAMC1 gene and close to the LAMC2 gene.…”

Section: Discussionmentioning

confidence: 99%

The rs2147578 C > G polymorphism in the Inc-LAMC2–1:1 gene is associated with increased neuroblastoma risk in the Henan children

Yang

Zhang

et al. 2018

BMC Cancer

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BackgroundThe rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2–1:1 is associated with increased susceptibility to a few types of cancers. However, its role in neuroblastoma has not been evaluated yet.MethodsWe investigated the association between the lnc-LAMC2–1:1 rs2147578 C > G polymorphism and neuroblastoma susceptibility in Chinese Han populations. A total of 393 neuroblastoma cases and 812 healthy individuals from the Henan and Guangdong provinces were enrolled and subjected to genotyping. Odds ratio (OR) and 95% confidence interval (CI) were used to determine the strength of the association of interest.ResultsCombined analysis revealed that the lnc-LAMC2–1:1 rs2147578 C > G polymorphism was associated with increased neuroblastoma susceptibility (CG vs. CC: adjusted OR = 1.33, 95% CI = 1.01–1.75, P = 0.045; CG/GG vs. CC: adjusted OR = 1.34, 95% CI = 1.03–1.74, P = 0.028). In stratification analysis, children under 18 months with rs2147578 CG/GG genotypes had an increased neuroblastoma risk (adjusted OR = 1.70, 95% CI = 1.08–2.67, P = 0.022). Females with rs2147578 CG/GG genotypes also had increased neuroblastoma susceptibility (adjusted OR = 2.08, 95% CI = 1.37–3.18, P = 0.0007). In addition, children with lnc-LAMC2–1:1 rs2147578 CG/GG genotypes were prone to develop earlier stages of neuroblastoma (adjusted OR = 1.46, 95% CI = 1.01–2.12, P = 0.046).ConclusionsThe Lnc-LAMC2–1:1 rs2147578 C > G polymorphism may contribute to increased neuroblastoma susceptibility in children of Henan province.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4847-y) contains supplementary material, which is available to authorized users.

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LncRNA-MALAT1-mediated Axl promotes cell invasion and migration in human neuroblastoma

Cited by 27 publications

References 24 publications

New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis

New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

The rs2147578 C > G polymorphism in the Inc-LAMC2–1:1 gene is associated with increased neuroblastoma risk in the Henan children

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