lncRNA MALAT1 contributes to neuropathic pain development through regulating miR-129-5p/HMGB1 axis in a rat model of chronic constriction injury

Ma, Xiaojing; Wang, Hong; Song, Tieying; Wang, Wenli; Zhang, Zaiwang

doi:10.1080/00207454.2020.1731508

Cited by 18 publications

(16 citation statements)

References 36 publications

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“…In recent years, studies have shown that the mutual regulation between lncRNAs and miRNAs plays an essential role in the occurrence and development of neuropathic pain. Ma et al showed in the CCI model that downregulating the lncRNA MALAT1 inhibits the development of neuropathic pain through regulation of the miR-129-5p/ HMGB1 axis (28). In addition, deletion of SNHG4 (small nucleolar RNA host gene 4) inhibited neuroinflammation and neuropathic pain by targeting miR-423-5p (29).…”

Section: Discussionmentioning

confidence: 99%

The long intergenic non-protein coding RNA 472 (LINC00472) aggravates neuropathic pain through the microRNA-300/high mobility group box protein 1 axis: a study using the chronic constrictive injury rat model

Zhang¹,

Liu²,

Ling³

et al. 2021

Ann Palliat Med

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Section: Discussionmentioning

confidence: 99%

The long intergenic non-protein coding RNA 472 (LINC00472) aggravates neuropathic pain through the microRNA-300/high mobility group box protein 1 axis: a study using the chronic constrictive injury rat model

Zhang¹,

Liu²,

Ling³

et al. 2021

Ann Palliat Med

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“…Several studies have indicated that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) significantly increased in the spinal cord or Schwann cells. Reducing the expression of MALAT1 could improve pain-like behavior and repress the progression of inflammation, proliferation, and migration by regulating target genes [107][108][109][110]. The lncRNAs uc.48+ [111][112][113], BC168687 [114][115][116], and NONRATT021972 [117][118][119] were also upregulated in the NP animal models.…”

Section: Lncrnas and Npmentioning

confidence: 97%

“…In addition, there were articles reporting that the lncRNA MALAT1 participated in the process of NP by sponging miRNA-154-5p, miR-129-5p, and miR-206. The downregulation of MALAT1 or its target mRNAs helps relieve pain and repress inflammation, proliferation, and migration [107][108][109][110]. Yao et al demonstrated that the lncRNA TNXA-PS1 was significantly decreased in the DRG of SNI rats.…”

Section: Interactions Among Lncrnas Mirnas and Mrnas In Npmentioning

confidence: 99%

Interactions Among lncRNAs/circRNAs, miRNAs, and mRNAs in Neuropathic Pain

et al. 2020

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Neuropathic pain (NP) is directly caused by an injury or disease of the somatosensory nervous system. It is a serious type of chronic pain that is a burden to the economy and public health. Although recent studies have improved our understanding of NP, its pathogenesis has not been fully elucidated. Noncoding RNAs, including lncRNAs, circRNAs, and miRNAs, are involved in the pathological development of NP through many mechanisms. In addition, extensive evidence suggests that novel regulatory mechanisms among lncRNAs/circRNAs, miRNAs, and mRNAs play a crucial role in the pathophysiological process of NP. In this review, we comprehensively summarize the regulatory relationship among lncRNAs/circRNAs, miRNAs, and mRNAs and emphasize the important role of the lncRNA/circRNA-miRNA-mRNA axis in NP.

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“…Long noncoding RNA (lncRNA), a class of oligonucleotides longer than 200 nucleotides, bears no protein-coding potentials ( Ma et al, 2020 ; Wang et al, 2020 ). Increasing evidence indicated that lncRNAs exert crucial functions in gene regulation and biological process, such as inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…Increasing evidence indicated that lncRNAs exert crucial functions in gene regulation and biological process, such as inflammation. For example, neuropathic pain and neuroinflammation can be aggravated by lncRNA MALAT1 by regulating the miR-129-5p /HMGB1 axis ( Ma et al, 2020 ). X inactivate-specific transcript (XIST), located on the long (q) arm of the X chromosome, contributes to neuropathic pain progression in rats ( Sun et al, 2018 ; Wei et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis

et al. 2021

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The objective of this study is to investigate the effect of long noncoding RNA (lncRNA) XIST on postoperative pain and inflammation of plantar incision pain (PIP) in rats and its underlying mechanisms. PIP rat models were established by plantar incision. Rats in the sham group were subjected to povidone-iodine scrubbing, and no incision was made. To explore the role of XIST/ miR-340-5p/RAB1A in postoperative pain and inflammation, PIP rats were separately or simultaneously injected with lentivirus containing sh-NC, sh-XIST, mimic NC, miR-340-5p mimic, inhibitor NC, miR-340-5p inhibitor, pcDNA3.1, or pcDNA3.1-RAB1A through an intrathecal catheter. The paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) values of rats in each group were assessed to evaluate the pain behavior. RT-qPCR and Western blot were utilized to determine the levels of XIST, miR-340-5p, RAB1A, and NF-κB pathway-related proteins (p-IκBα, IκBα, p-p65, and p65). The concentrations of inflammatory cytokines (TNF-α, IL-1β, and IL-6) in rat spinal dorsal horn tissues were inspected by ELISA. H and E staining was applied to observe the pathological changes of neurons in the spinal dorsal horn, TUNEL staining to detect neuronal apoptosis, and immunohistochemistry to measure RAB1A level. Plantar incision surgery caused decreased PWT and PWL values, enhanced levels of XIST, RAB1A, and inflammatory cytokines, along with an increased proportion of apoptotic neurons. The pain sensitivity and inflammation of rats were motivated after plantar incision surgery. Intrathecal injection of sh-XIST or miR-340-5p mimic ameliorated the pain and inflammation of PIP rats, while silencing of miR-340-5p or overexpression of RAB1A partly reversed the effect of sh-XIST on PIP rats. XIST targeted miR-340-5p and miR-340-5p negatively regulated RAB1A. The XIST/ miR-340-5p/RAB1A axis activated the NF-κB signaling pathway. LncRNA XIST aggravates inflammatory response and postoperative pain of PIP rats by activating the NF-κB pathway via the miR-340-5p/RAB1A axis.

show abstract

lncRNA MALAT1 contributes to neuropathic pain development through regulating miR-129-5p/HMGB1 axis in a rat model of chronic constriction injury

Cited by 18 publications

References 36 publications

The long intergenic non-protein coding RNA 472 (LINC00472) aggravates neuropathic pain through the microRNA-300/high mobility group box protein 1 axis: a study using the chronic constrictive injury rat model

The long intergenic non-protein coding RNA 472 (LINC00472) aggravates neuropathic pain through the microRNA-300/high mobility group box protein 1 axis: a study using the chronic constrictive injury rat model

Interactions Among lncRNAs/circRNAs, miRNAs, and mRNAs in Neuropathic Pain

Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis

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