lncRNA LINC01057 promotes mesenchymal differentiation by activating NF-κB signaling in glioblastoma

Tang, Guodong; Luo, Li; Zhang, Jianlei; Zhai, Dongfeng; Huang, Dongzhou; Yin, Jun; Zhou, Qin; Zhang, Qiong; Zheng, Guopei

doi:10.1016/j.canlet.2020.10.047

Cited by 39 publications

(27 citation statements)

References 41 publications

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“…(2021) revealed that LINC01057 was remarkably higher in mesenchymal GBM tissue. It was also shown that LINC01057 regulates NF-κB signaling to acquire mesenchymal phenotype in GBM (Tang et al, 2021).…”

Section: Nf-κb Pathwaymentioning

confidence: 97%

Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets

Yadav

Kulshreshtha

2021

Journal Cellular Physiology

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Glioblastoma (GBM) is the most aggressive, malignant, and therapeutically challenging Grade IV tumor of the brain. Although the possibility of distant metastasis is extremely rare, GBM is known to cause intracranial metastasis forming aggressive secondary lesions resulting in a dismal prognosis. Metastasis also plays an important role in tumor dissemination and recurrence making GBM largely incurable. Recent studies have indicated the importance of long noncoding RNAs (lncRNAs) in GBM metastasis. lncRNAs are a class of regulatory noncoding RNAs (>200 nt) that interact with DNA, RNA, and proteins to regulate various biological processes. This is the first comprehensive review summarizing the lncRNAs associated with GBM metastasis and the underlying molecular mechanism involved in migration/invasion. We also highlight the complex network of lncRNA/miRNA/protein that collaborate/compete to regulate metastasis-associated genes. Many of these lncRNAs also show attractive potential as diagnostic/prognostic biomarkers. Finally, we discuss various therapeutic strategies and potential applications of lncRNAs as therapeutic targets for the treatment of GBM.

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Section: Nf-κb Pathwaymentioning

confidence: 97%

Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets

Yadav

Kulshreshtha

2021

Journal Cellular Physiology

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“…Long non-coding (lnc)RNAs are RNA molecules, >200 nucleotides in length, which are involved in different types of cellular processes, such as proliferation, migration and differentiation (9)(10)(11)(12)(13). Previous studies have demonstrated that lncRNAs are important regulatory factors that participate in cell proliferation, invasion and metastasis (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA MCM3AP‑AS1 facilitates colorectal cancer progression by regulating the microRNA‑599/ARPP19 axis

2021

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Colorectal cancer (CRC) is one of the most aggressive malignancies worldwide. Increasing evidence has indicated that microRNA (miR)-599 is involved in the occurrence and development of different types of tumors, such as breast cancer and glioma. However, the role of miR-599 in CRC remains unclear. Thus, the present study aimed to identify the regulatory mechanism of miR-599 in CRC progression. Reverse transcription-quantitative PCR was used to analyze the expression levels of MCM3AP-AS1, miR-599 and ARPP19, and Cell Counting Kit-8 and Transwell assays were used to determine the cell proliferation and migration of CRC cells. In addition, a Dual-luciferase reporter assay was used to analyze the direct interaction between miR-599 and MCM3AP-AS1 or ARPP19. Reverse transcription-quantitative PCR analysis demonstrated that miR-599 expression decreased in patients with CRC and in CRC cell lines, while miR-599 overexpression inhibited cell proliferation and migration abilities in vitro . MCM3AP-AS1 was identified as a molecular sponge of miR-599, and further investigation indicated that MCM3AP-AS1 silencing inhibited cell proliferation and migration of the CRC cell lines. In addition, ARPP19 was identified as a target gene of miR-599, and MCM3AP-AS1-knockdown decreased ARPP19 mRNA expression and increased miR-599 expression. Furthermore, silencing ARPP19 inhibited the proliferation and migration of the CRC cell lines. The results also demonstrated that MCM3AP-AS1 promoted CRC cell progression by regulating the miR-599/ARPP19 axis. Taken together, the results of the present study suggest that MCM3AP-AS1 may be a novel therapeutic target for patients with CRC.

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“…It can cause mRNA degradation or translation repression by sponging miRNAs (a type of small single-strand ncRNA with 19–26 nt) [ 15 – 17 ]. According to recent research, lncRNAs have both direct and indirect regulatory effects in the biological process of cancer [ 18 – 20 ]. Also, it has been reported that lncRNAs are related to the recurrence, metastasis, and prognosis of LUAD [ 21 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

ITGB1-DT/ARNTL2 axis may be a novel biomarker in lung adenocarcinoma: a bioinformatics analysis and experimental validation

et al. 2021

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Background Lung cancer is one of the most lethal malignant tumors that endangers human health. Lung adenocarcinoma (LUAD) has increased dramatically in recent decades, accounting for nearly 40% of all lung cancer cases. Increasing evidence points to the importance of the competitive endogenous RNA (ceRNA) intrinsic mechanism in various human cancers. However, behavioral characteristics of the ceRNA network in lung adenocarcinoma need further study. Methods Groups based on SLC2A1 expression were used in this study to identify associated ceRNA networks and potential prognostic markers in lung adenocarcinoma. The Cancer Genome Atlas (TCGA) database was used to obtain the patients' lncRNA, miRNA, and mRNA expression profiles, as well as clinical data. Informatics techniques were used to investigate the effect of hub genes on prognosis. The Cox regression analyses were performed to evaluate the prognostic effect of hub genes. The methylation, GSEA, and immune infiltration analyses were utilized to explore the potential mechanisms of the hub gene. The CCK-8, transwell, and colony formation assays were performed to detect the proliferation and invasion of lung cancer cells. Results We eventually identified the ITGB1-DT/ARNTL2 axis as an independent fact may promote lung adenocarcinoma progression. Furthermore, methylation analysis revealed that hypo-methylation may cause the dysregulated ITGB1-DT/ARNTL2 axis, and immune infiltration analysis revealed that the ITGB1-DT/ARNTL2 axis may affect the immune microenvironment and the progression of lung adenocarcinoma. The CCK-8, transwell, and colonu formation assays suggested that ITGB1-DT/ARNTL2 promotes the progression of lung adenocarcinoma. And hsa-miR-30b-3p reversed the ITGB1/ARNTL2-mediated oncogenic processes. Conclusion Our study identified the ITGB1-DT/ARNTL2 axis as a novel prognostic biomarker affects the prognosis of lung adenocarcinoma.

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lncRNA LINC01057 promotes mesenchymal differentiation by activating NF-κB signaling in glioblastoma

Cited by 39 publications

References 41 publications

Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets

Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets

Long non‑coding RNA MCM3AP‑AS1 facilitates colorectal cancer progression by regulating the microRNA‑599/ARPP19 axis

ITGB1-DT/ARNTL2 axis may be a novel biomarker in lung adenocarcinoma: a bioinformatics analysis and experimental validation

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