LncRNA H19: A novel oncogene in multiple cancers

Yang, Jun; Qi, Manlong; Fei, Xiang; Wang, Xia; Wang, Kefeng

doi:10.7150/ijbs.62573

Cited by 73 publications

(65 citation statements)

References 176 publications

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“…Due to the regulation of pathogenic genes in a variety of ways and the important impact of immune microenvironment on the prognosis of colorectal cancer [ 18 , 19 ], Therefore, we explored the relationship between KCNJ14 expression and immune cell infiltration through the TIMER database to reveal the effect of KCNJ14 expression on immune microenvironment. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells

Pan

et al. 2022

BMC Med Genomics

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Background This study attempted to verify the potential of KCNJ14 as a biomarker in colorectal cancer (CRC). Methods Data on transcriptomics and DNA methylation and the clinical information of CRC patients were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. Biological information analysis methods were conducted to determine the role of KCNJ14 in the prognosis, diagnosis, immune cell infiltration, and regulation mechanism of CRC patients. The effect of KCNJ14 on the proliferation and migration of HCT116 and SW480 CRC cell lines was verified by in vitro experiments (MTT, colony-forming, wound healing, and transwell assays). Western blotting was performed to detect the effect of KCNJ14 on the levels of mTOR signalling pathway-related proteins. Results KCNJ14 expression was remarkably increased in CRC tissues and cell lines, which reduced the overall survival time of patients. KCNJ14 mRNA was negatively regulated by its methylation site cg17660703, which can also endanger the prognosis of patients with CRC. Functional enrichment analysis suggested that KCNJ14 is involved in the mTOR, NOD-like receptor, and VEGF signalling pathways. KCNJ14 expression was positively correlated with the number of CD4 + T cells and negatively correlated with that of CD8 + T cells in the immune microenvironment. KCNJ14 knockdown significantly reduced not only the proliferation and migration of CRC cell lines but also the levels of mTOR signalling pathway-related proteins. Conclusions This study not only increases the molecular understanding of KCNJ14 but also provides a potentially valuable biological target for the treatment of colorectal cancer.

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Section: Resultsmentioning

confidence: 99%

KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells

Pan

et al. 2022

BMC Med Genomics

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“…An aberrant imprinting IGF-II locus was detected in CRC, leading to an overexpression of IGF-II and, subsequently, to higher proliferation rate and invasiveness [ 146 , 147 , 148 , 149 ]. The same imprinted region also contains a gene encoding H19, a long non-coding RNA (lncRNA) with a known regulatory role in the molecular basis of CRC carcinogenesis [ 150 , 151 ].…”

Section: Insulin-like Growth Factors and Colorectal Cancermentioning

confidence: 99%

The Insulin-like Growth Factor System and Colorectal Cancer

Gligorijević

Dobrijević

Šunderić

et al. 2022

Life

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Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine activities. Together with their receptors, binding proteins and associated molecules, they participate in numerous pathophysiological processes, including cancer development. Colorectal cancer (CRC) is a disease with high incidence and mortality rates worldwide, whose etiology usually represents a combination of the environmental and genetic factors. IGFs are most often increased in CRC, enabling excessive autocrine/paracrine stimulation of the cell growth. Overexpression or increased activation/accessibility of IGF receptors is a coinciding step which transmits IGF-related signals. A number of molecules and biochemical mechanisms exert modulatory effects shaping the final outcome of the IGF-stimulated processes, frequently leading to neoplastic transformation in the case of irreparable disbalance. The IGF system and related molecules and pathways which participate in the development of CRC are the focus of this review.

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“…Recently, It's been a research focus due to its oncogenic properties in different kinds of cancers, including gastric, colorectal, and hepatocellular tumors. 106 The interactions between H19, miR-107, and NF1 genes in NSCLC patients have been investigated. NSCLC cell lines were found to exhibit overexpressed H19 and NF1, leading to their higher cell proliferation and migration.…”

Section: Lncrna H19mentioning

confidence: 99%

The role of miRNAs and lncRNAs in neurofibromatosis type 1

Khosravi

Oladnabi

2022

J of Cellular Biochemistry

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Neurofibromatosis Type 1 (NF1) is a frequent cancer predisposition syndrome. The common hallmark of patients with this multisystemic genetic disorder is the formation of peripheral nerve sheath tumors, which can be seen as either dermal, plexiform, and malignant forms. MicroRNA (miRNA) is an essential gene regulation factor and consists of 22–25 nucleotides. MiRNAs are identified to act as both tumor suppressors and oncogenes (oncomirs) in a wide variety of human cancers. They play multiple roles in molecular pathways responsible for tumor homing, progression, and invasion. Long noncoding RNA (lncRNA) also has a key role in cancer transcriptomics. Altered lncRNA expression levels have been found in various malignancies. This review aims to summarize the role of two noncoding RNA groups, miRNAs and lncRNAs, in NF1 establishment, development, and progression. We also highlight their potential for future clinical interventions and devising new diagnostic tools.

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LncRNA H19: A novel oncogene in multiple cancers

Cited by 73 publications

References 176 publications

KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells

KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells

The Insulin-like Growth Factor System and Colorectal Cancer

The role of miRNAs and lncRNAs in neurofibromatosis type 1

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