2017
DOI: 10.1177/1010428317711315
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Abstract: Growth arrest special 5 (GAS5) is a long non-coding RNA reported to function as an inhibitor in various tumors including cervical cancer. However, the molecular mechanism of GAS5 involved in cervical cancer progression remains far from being elucidated. The expression of GAS5, forkhead box protein O1 and phosphatase and tensin homolog was examined by quantitative reverse transcription polymerase chain reaction qRT-PCR. cell growth, invasion, and apoptosis were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphe… Show more

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Cited by 78 publications
(54 citation statements)
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“…As previously stated, PTEN itself is a relatively classical protein that promotes apoptosis (45). Although the mechanisms of lncRNAs are complex, the biological function of lncRNA GAS5 is mostly mediated through the ceRNA mechanism, according to previous studies (57,58). lncRNA GAS5 has also been reported to be involved in biological processes including apoptosis, through a variety of mechanisms associated with PTEN (36).…”
Section: Discussionmentioning
confidence: 92%
“…As previously stated, PTEN itself is a relatively classical protein that promotes apoptosis (45). Although the mechanisms of lncRNAs are complex, the biological function of lncRNA GAS5 is mostly mediated through the ceRNA mechanism, according to previous studies (57,58). lncRNA GAS5 has also been reported to be involved in biological processes including apoptosis, through a variety of mechanisms associated with PTEN (36).…”
Section: Discussionmentioning
confidence: 92%
“…Recently, increasing evidence indicated that decreasing expression of GAS5 can affect the susceptibility of many kinds of cancers and associated with poorer prognosis of hepatocellular carcinoma, cervical cancer, renal cancer, lung cancer, gastric cancer and melanoma [24][25][26][30][31][32]. The rs145204276 ins/del polymorphism can regulate the expression of GAS5 through affecting one CpG island methylation condition [24].…”
Section: Discussionmentioning
confidence: 99%
“…Cervical cancer (CC) is the second most common cancer in women worldwide, and it is the leading cause of cancer death among women in developing countries. 61 GAS5 expression was decreased in CC tissues and cells as well 30,31,84,85 and was associated with FIGO stage, tumor invasion and metastasis of CC patients. 30 Patients with lower expression of GAS5 had shorter OS than those with higher GAS5 expression in CC.…”
Section: Clinical Relevancementioning
confidence: 93%
“…In recent years, GAS5 has raised increased attention due to its downregulation in a wide variety of malignancies, including non-small cell lung cancer (NSCLC), 16,17 breast cancer (BC), 18,19 hepatocellular carcinoma (HCC), 20,21 esophageal carcinoma (EC), 22,23 gastric cancer (GC), 24,25 colorectal cancer (CRC), 26,27 pancreatic cancer (PC), 28,29 cervical cancer (CC), 30,31 ovarian cancer (OC), 32,33 renal cell carcinoma (RCC) 34,35 (Figure 1). Clinicopathological characteristics, such as overall survival (OS), disease-free survival (DFS), distant metastasis (DM), lymph node metastasis (LNM), tumor node stage (TNM) and tumor size, are highly correlated with the level of GAS5 expression in cancers, 16,19,27,36,37 indicating that GAS5 can be a novel diagnostic and prognostic biomarker, as well as therapeutic target in many human cancers.…”
Section: Gas5 In Cancermentioning
confidence: 99%