LncRNA‐AK137033 inhibits the osteogenic potential of adipose‐derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation

Peng, Shuanglin; Gao, Yujin; Shi, Sirong; Zhao, Dan; Cao, Huayue; Fu, Ting; Cai, Xiaoxiao; Xiao, Jingang

doi:10.1111/cpr.13174

Cited by 20 publications

(8 citation statements)

References 61 publications

(82 reference statements)

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“…However, the current treatment methods for bone reconstruction in diabetic patients are suboptimal. Because of the reduced osteogenic potential of ASCs in the diabetic environment, bone regeneration is di cult in patients with diabetes and bone damage [30]. However, the mechanism of the reduced osteogenic differentiation potential of ASCs in the diabetic microenvironment is not fully clear.…”

Section: Discussionmentioning

confidence: 99%

Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells in mice through autophagy

Zhu

Lou

et al. 2023

Cellular Signalling

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Section: Discussionmentioning

confidence: 99%

Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells in mice through autophagy

Zhu

Lou

et al. 2023

Cellular Signalling

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“…For example, LncRNA-AK137033 expression, DNA methylation levels in the sFrp2 promoter region, Wnt signaling pathway markers, and osteogenic differentiation potential are all reduced in MSCs isolated from diabetic osteoporosis (DOP) bone-deficient mice. In contrast, silencing AK137033 inhibited the Wnt signaling pathway and osteogenic capacity of CON MSCs by reducing the DNA methylation level of the sFrp2 promoter region ( 84 ).…”

Section: Epigenetic Control Of Mscs In Bone Regenerationmentioning

confidence: 99%

Epigenetic control of mesenchymal stem cells orchestrates bone regeneration

2023

Front. Endocrinol.

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Recent studies have revealed the vital role of MSCs in bone regeneration. In both self-healing bone regeneration processes and biomaterial-induced healing of bone defects beyond the critical size, MSCs show several functions, including osteogenic differentiation and thus providing seed cells. However, adverse factors such as drug intake and body senescence can significantly affect the functions of MSCs in bone regeneration. Currently, several modalities have been developed to regulate MSCs’ phenotype and promote the bone regeneration process. Epigenetic regulation has received much attention because of its heritable nature. Indeed, epigenetic regulation of MSCs is involved in the pathogenesis of a variety of disorders of bone metabolism. Moreover, studies using epigenetic regulation to treat diseases are also being reported. At the same time, the effects of epigenetic regulation on MSCs are yet to be fully understood. This review focuses on recent advances in the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs. We intend to illustrate how epigenetic regulation of MSCs orchestrates the process of bone regeneration.

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“…The canonical Wnt signaling pathway controls the physiology of stem cells in many other tissues, such as bone, in which the lncRNA AK137033 has been shown in vitro and in vivo to inhibit the osteogenic potential of adipose-derived stem cells in patients with diabetic osteoporosis. The non-coding transcript acts as an epigenetic regulator by modulating the Wnt signaling pathway via DNA methylation in the sFrp2 promoter region [ 118 ].…”

Section: The Impact Of Lncrnas On Stem Cells In Diseasementioning

confidence: 99%

The Mission of Long Non-Coding RNAs in Human Adult Renal Stem/Progenitor Cells and Renal Diseases

Giannuzzi

Maiullari

Gesualdo

et al. 2023

Cells

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Long non-coding RNAs (lncRNAs) are a large, heterogeneous class of transcripts and key regulators of gene expression at both the transcriptional and post-transcriptional levels in different cellular contexts and biological processes. Understanding the potential mechanisms of action of lncRNAs and their role in disease onset and development may open up new possibilities for therapeutic approaches in the future. LncRNAs also play an important role in renal pathogenesis. However, little is known about lncRNAs that are expressed in the healthy kidney and that are involved in renal cell homeostasis and development, and even less is known about lncRNAs involved in human adult renal stem/progenitor cells (ARPC) homeostasis. Here we give a thorough overview of the biogenesis, degradation, and functions of lncRNAs and highlight our current understanding of their functional roles in kidney diseases. We also discuss how lncRNAs regulate stem cell biology, focusing finally on their role in human adult renal stem/progenitor cells, in which the lncRNA HOTAIR prevents them from becoming senescent and supports these cells to secrete high quantities of α-Klotho, an anti-aging protein capable of influencing the surrounding tissues and therefore modulating the renal aging.

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LncRNA‐AK137033 inhibits the osteogenic potential of adipose‐derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 20 publications

References 61 publications

Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells in mice through autophagy

Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells in mice through autophagy

Epigenetic control of mesenchymal stem cells orchestrates bone regeneration

The Mission of Long Non-Coding RNAs in Human Adult Renal Stem/Progenitor Cells and Renal Diseases

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