LMI-Based Synchronization Conditions to R-L Fractional Time-Varying Delayed Neural Networks with Parametric Uncertainty

Zhang, Hongmei; Zhang, Hai; Zhang, Weiwei; Alsaedi, Ahmed

doi:10.1007/s11063-022-11026-x

Cited by 3 publications

(1 citation statement)

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“…[ 52 ] The Nissl bodies are the principal component of the neuronal protein synthesis machinery. [ 70,71 ] Here, AgNPs treatment adversely impacted morphological modifications on the ribosome synthesis of amino acids as verified by marked reduction in the cresyl fast violet stained Nissl substances. The marked diminution in the neuronal protein synthesizing machinery, which may be related to cellular oxidative damage and histological injury, could impede neurotransmitter synthesis, neuron repair and consequently, lead to cell death in the AgNPs‐treated rats.…”

Section: Discussionmentioning

confidence: 93%

Amelioration of neurobehavioral, biochemical, and morphological alterations associated with silver nanoparticles exposure by taurine in rats

Njoku,

Ileola‐Gold,

Adelaja

et al. 2023

J Biochem & Molecular Tox

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The adverse effect of silver nanoparticles (AgNPs) on the nervous system is an emerging concern of public interest globally. Taurine, an essential amino acid required for neurogenesis in the nervous system, is well‐documented to possess antioxidant, anti‐inflammatory, and antiapoptotic activities. Yet, there is no report in the literature on the effect of taurine on neurotoxicity related to AgNPs exposure. Here, we investigated the neurobehavioral and biochemical responses associated with coexposure to AgNPs (200 µg/kg body weight) and taurine (50 and 100 mg/kg body weight) in rats. Locomotor incompetence, motor deficits, and anxiogenic‐like behavior induced by AgNPs were significantly alleviated by both doses of taurine. Taurine administration enhanced exploratory behavior typified by increased track plot densities with diminished heat maps intensity in AgNPs‐treated rats. Biochemical data indicated that the reduction in cerebral and cerebellar acetylcholinesterase activity, antioxidant enzyme activities, and glutathione level by AgNPs treatment were markedly upturned by both doses of taurine. The significant abatement in cerebral and cerebellar oxidative stress indices namely reactive oxygen and nitrogen species, hydrogen peroxide, and lipid peroxidation was evident in rats cotreated with AgNPs and taurine. Further, taurine administration abated nitric oxide and tumor necrosis factor‐alpha levels cum myeloperoxidase and caspase‐3 activities in AgNPs‐treated rats. Amelioration of AgNPs‐induced neurotoxicity by taurine was confirmed by histochemical staining and histomorphometry. In conclusion, taurine via attenuation of oxido‐inflammatory stress and caspase‐3 activation protected against neurotoxicity induced by AgNPs in rats.

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Section: Discussionmentioning

confidence: 93%