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Lawson, E. C.; Weiss, James D.; Thomas, P. E.; Kaniewski, Wojciech

doi:10.1023/a:1009637325028

Cited by 29 publications

(6 citation statements)

References 35 publications

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“…CP plays an important role in viral translation and activation of host R genes and helps cell-to-cell virus propagation . Resistance against PLRV is achieved by inserting and expressing the replicase gene . In the case of resistance to both viruses, GM potato plants do not express a detectable amount of transgenic proteins inserted.…”

Section: Potato Virus Diseases (Potato Virus Y and Potato Leafroll Vi...mentioning

confidence: 99%

Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

Křížkovská

Viktorová

Lipov

2022

J. Agric. Food Chem.

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Potatoes (Solanum tuberosum) are one of the most important crops worldwide. However, its production and nutrient content are endangered by both biotic and abiotic stresses. The main yield losses are caused by pest damage (e.g., Colorado potato beetle and aphids), virus disease (e.g., Potato leafroll virus and Potato viruses Y and X), or oomycete pathogens (like Phytophthora infestans), which also significantly affect the production of antinutrients and toxic metabolites of plants. Therefore, the use of genetic engineering could be an efficient tool, not harmful to the environment, and beneficial to the consumer. In this review, we focus on the main sources of problems in the field of potato production according to approved genetic modifications, their traditional solution and positive impact of gene transfection reducing economic losses, use of insecticides, and improving the nutritional properties of potatoes. We summarize all transgenic events that have been performed on potatoes and have been approved for cultivation and/or direct use or processing as feed or food.

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Section: Potato Virus Diseases (Potato Virus Y and Potato Leafroll Vi...mentioning

confidence: 99%

Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

Křížkovská

Viktorová

Lipov

2022

J. Agric. Food Chem.

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“… 14 In addition, the insect has developed resistance to active ingredients of many of the synthetic insecticides used, including numerous pyrethrins. 93 , 94 These issues have prompted a search for alternative pest management strategies.…”

Section: Genetically Modified Characteristics In Potatomentioning

confidence: 99%

“…Russet Burbank, which had added potato leafroll virus (PLRV) resistance. 93 However, by 2001 commercialization had halted due to low profits most likely triggered by the rejection of GM potato by food companies. 2 …”

Section: Genetically Modified Characteristics In Potatomentioning

confidence: 99%

Potato improvement through genetic engineering

2021

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Potato ( Solanum tuberosum L.) is the third most important crop worldwide and a staple food for many people worldwide. Genetically, it poses many challenges for traditional breeding due to its autotetraploid nature and its tendency toward inbreeding depression. Breeding programs have focused on productivity, nutritional quality, and disease resistance. Some of these traits exist in wild potato relatives but their introgression into elite cultivars can take many years and, for traits such as pest resistance, their effect is often short-lasting. These problems can be addressed by genetic modification (GM) or gene editing (GE) and open a wide horizon for potato crop improvement. Current genetically modified and gene edited varieties include those with Colorado potato beetle and late blight resistance, reduction in acrylamide, and modified starch content. RNAi hairpin technology can be used to silence the haplo-alleles of multiple genes simultaneously, whereas optimization of newer gene editing technologies such as base and prime editing will facilitate the routine generation of advanced edits across the genome. These technologies will likely gain further relevance as increased target specificity and decreased off-target effects are demonstrated. In this Review, we discuss recent work related to these technologies in potato improvement.

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“…The transgenic line exhibiting resistance to PVY was approved in 1998, and are marketed and cultivated in the USA and Canada under the trade name "Hi-Lite NewLeaf TMY " and "NewLeaf™ Y", respectively [90,110]. This effort was followed by the transformation of the same cultivar with the two open reading frames (ORFs) of PLRV RdRp, ORF1 and ORF2, respectively, to produce two PLRV-resistant lines approved for marketing in the USA and Canada under the name "NewLeaf™ Plus" [111,112]. Overall, 14 transgenic potato lines have been approved for cultivation in North America [90].…”

Section: Potato (Resistance To Pvy and Plrv)mentioning

confidence: 99%

Development and Adoption of Genetically Engineered Plants for Virus Resistance: Advances, Opportunities and Challenges

Niraula

Fondong

2021

Plants

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Plant viruses cause yield losses to crops of agronomic and economic significance and are a challenge to the achievement of global food security. Although conventional plant breeding has played an important role in managing plant viral diseases, it will unlikely meet the challenges posed by the frequent emergence of novel and more virulent viral species or viral strains. Hence there is an urgent need to seek alternative strategies of virus control that can be more readily deployed to contain viral diseases. The discovery in the late 1980s that viral genes can be introduced into plants to engineer resistance to the cognate virus provided a new avenue for virus disease control. Subsequent advances in genomics and biotechnology have led to the refinement and expansion of genetic engineering (GE) strategies in crop improvement. Importantly, many of the drawbacks of conventional breeding, such as long lead times, inability or difficulty to cross fertilize, loss of desirable plant traits, are overcome by GE. Unfortunately, public skepticism towards genetically modified (GM) crops and other factors have dampened the early promise of GE efforts. These concerns are principally about the possible negative effects of transgenes to humans and animals, as well as to the environment. However, with regards to engineering for virus resistance, these risks are overstated given that most virus resistance engineering strategies involve transfer of viral genes or genomic segments to plants. These viral genomes are found in infected plant cells and have not been associated with any adverse effects in humans or animals. Thus, integrating antiviral genes of virus origin into plant genomes is hardly unnatural as suggested by GM crop skeptics. Moreover, advances in deep sequencing have resulted in the sequencing of large numbers of plant genomes and the revelation of widespread endogenization of viral genomes into plant genomes. This has raised the possibility that viral genome endogenization is part of an antiviral defense mechanism deployed by the plant during its evolutionary past. Thus, GM crops engineered for viral resistance would likely be acceptable to the public if regulatory policies were product-based (the North America regulatory model), as opposed to process-based. This review discusses some of the benefits to be gained from adopting GE for virus resistance, as well as the challenges that must be overcome to leverage this technology. Furthermore, regulatory policies impacting virus-resistant GM crops and some success cases of virus-resistant GM crops approved so far for cultivation are discussed.

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Untitled

Cited by 29 publications

References 35 publications

Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

Approved Genetically Modified Potatoes (Solanum tuberosum) for Improved Stress Resistance and Food Safety

Potato improvement through genetic engineering

Development and Adoption of Genetically Engineered Plants for Virus Resistance: Advances, Opportunities and Challenges

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