2020
DOI: 10.21203/rs.3.rs-105982/v1
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Abstract: Abstract Background: Oncogenic KRAS mutations combined with loss of the LKB1 tumor-suppressor gene (KL) are strongly associated with aggressive forms of lung cancer. N6-methyladenosine (m6A) in mRNA is a crucial epigenetic modification that controls cancer self-renewal and progression. However, the function, regulation and mechanism of m6A in this aggressive phenotypes remain largely unclear.Methods: The clinic-pathological role of m6A was evaluated in a cohort of lung cancer tissues and further valida…

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