Living with prostate cancer: randomised controlled trial of a multimodal supportive care intervention for men with prostate cancer

Abstract

BackgroundProstate cancer is the most common male cancer in developed countries and diagnosis and treatment carries with it substantial morbidity and related unmet supportive care needs. These difficulties may be amplified by physical inactivity and obesity. We propose to apply a multimodal intervention approach that targets both unmet supportive care needs and physical activity.Methods/designA two arm randomised controlled trial will compare usual care to a multimodal supportive care intervention "Living with Prostate Cancer" that will combine self-management with tele-based group peer support. A series of previously validated and reliable self-report measures will be administered to men at four time points: baseline/recruitment (when men are approximately 3-6 months post-diagnosis) and at 3, 6, and 12 months after recruitment and intervention commencement. Social constraints, social support, self-efficacy, group cohesion and therapeutic alliance will be included as potential moderators/mediators of intervention effect. Primary outcomes are unmet supportive care needs and physical activity levels. Secondary outcomes are domain-specific and health-related quality of life (QoL); psychological distress; benefit finding; body mass index and waist circumference. Disease variables (e.g. cancer grade, stage) will be assessed through medical and cancer registry records. An economic evaluation will be conducted alongside the randomised trial.DiscussionThis study will address a critical but as yet unanswered research question: to identify a population-based way to reduce unmet supportive care needs; promote regular physical activity; and improve disease-specific and health-related QoL for prostate cancer survivors. The study will also determine the cost-effectiveness of the intervention.Trial RegistrationACTRN12611000392965

Men's help‐seeking in the first year after diagnosis of localised prostate cancer

“…Men who were diagnosed with localised prostate cancer in the state of Queensland, Australia were recruited between September 2011 and November 2012 via the Queensland Cancer Registry as part of a randomised controlled trial that is ongoing (Chambers et al . ; Galvão et al . ).…”

“…Baseline assessment occurred via computer‐assisted telephone interview using previously validated and reliable self‐report measures (Chambers et al . ; Galvão et al . ).…”

Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1

“…Currently, PC is the second most frequently observed cancer worldwide and its morbidity rate is increasing annually (2). According to the World Health Organization (WHO), there were 899,000 new PC cases in 2008, which accounted for ~14% of new cancer cases in men worldwide (3). According to a prediction by the WHO, the number of patients with PC will have increased to 1.7 million by 2030 (4).…”

Sexual minority men and the experience of undergoing treatment for prostate cancer: An integrative review

“…However, the heterocentric environment of current support groups can cause additional harm through forced identity invisibility, dismissal of needs or prejudice. Previously studied peer-support interventions (Chambers et al, 2011) need to be trialled in GBQ men.…”