Liver Transplantation and Hepatic Resection can Achieve Cure for Hepatocellular Carcinoma

Pinna, Antonio Daniele; Yang, Tian; Mazzaferro, Vincenzo; Carlis, Luciano De; Zhou, Jian; Roayaie, Sasan; Sposito, Carlo; Cescon, Matteo; Sandro, Stefano Di; He, Yuchao; Johnson, Philip J.; Cucchetti, Alessandro

doi:10.1097/sla.0000000000002889

Cited by 141 publications

(132 citation statements)

References 30 publications

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“…14 However, a plateau may be visualized for survival curve after long-term follow-up, and this indicates the presence of cured subjects. [14][15][16] This is particularly true for patients with early-stage, resected lung adenocarcinomas. Given the long-term censored survival time of patients with clinical stage IA, resected adenocarcinomas, it was deemed reasonable to apply the cure model to these patients.…”

Section: Discussionmentioning

confidence: 99%

“…The cure model can capture the relationship between the covariates and long-term survivorship, 15 and it has been applied to oncology patients with various pathologic conditions for whom a cure is statistically plausible. [16][17][18] The covariates used in the mixture cure model were identical to those used in the Cox regression analysis. Cure fraction, which is the probability of being cured, was estimated for each nodule type.…”

Section: Discussionmentioning

confidence: 99%

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Validation of the Eighth Edition Clinical T Categorization System for Clinical Stage IA, Resected Lung Adenocarcinomas: Prognostic Implications of the Ground-Glass Opacity Component

Kim

Goo

Kim

et al. 2020

Journal of Thoracic Oncology

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Introduction: There is controversy regarding the clinical T (cT) category of lung adenocarcinomas that manifest as part-solid nodules (PSNs). We aimed to validate the cT category and to evaluate the independent prognostic role of the nodule type (i.e., part-solid versus solid). Methods: We retrospectively evaluated the prognostic value of clinico-radiologic factors regarding the overall survival of patients with clinical stage IA lung adenocarcinomas that were resected between 2008 and 2014. cT Category, nodule type, and their interaction term were included in the multivariable Cox regression analysis with other variables. In addition, a mixture cure model analysis was performed to investigate the association between the covariates and long-term survival. Results: A total of 744 patients (420 women; 362 PSNs; median age, 63 y) were included. The multivariableadjusted hazard ratio (HR) of the nodule type was not significant (1.30, 95% confidence interval [CI]: 0.80-2.10, p ¼ 0.291). However, the cT categories were significantly associated with overall survival (HR of cT1b, 2.33 [95% CI: 1.07-5.06, p ¼ 0.033]; HR of cT1c, 5.74 [95% CI: 2.51-13.12, p < 0.001]). There were no interactions between the nodule type and the cT categories (all p > 0.05). The multivariable mixture cure model revealed that solid nodules were associated with a decreased probability of long-term survival (OR ¼ 0.40, 95% CI: 0.18-0.92, p ¼ 0.030). In addition, cT1c was a negative predictor of long-term survival (OR ¼ 0.26, 95% CI: 0.07-0.94, p ¼ 0.040). Conclusions: The cT categorization system is valid for PSNs and solid nodules. Nevertheless, PSNs are a prognostic factor associated with long-term survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Validation of the Eighth Edition Clinical T Categorization System for Clinical Stage IA, Resected Lung Adenocarcinomas: Prognostic Implications of the Ground-Glass Opacity Component

Kim

Goo

Kim

et al. 2020

Journal of Thoracic Oncology

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“…Among all possible strategies to treat HCC, LT offers the best chance of cure. 9 Unfortunately, the number of available grafts is insufficient for all potential candidates. For this reason, LT is reserved for patients who will benefit most.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Recent advances in liver transplantation for cancer: The future of transplant oncology

et al. 2019

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Liver transplantation is widely indicated as a curative treatment for selected patients with hepatocellular carcinoma. However, with recent therapeutic advances, as well as efforts to increase the donor pool, liver transplantation has been carefully expanded to patients with other primary or secondary malignancies in the liver. Cholangiocarcinoma, colorectal and neuroendocrine liver metastases, and hepatic epithelioid haemangioendothelioma are amongst the most relevant new indications. In this review we discuss the fundamental concepts of this ambitious undertaking, as well as the newest indications for liver transplantation, with a special focus on future perspectives within the recently established concept of transplant oncology.

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“…We have already shown that the 'cure fraction' after transplantation for HCC is 74.1% compared to only 24.1% in the cases undergoing resection. 15 In the near future we hope to be able to add a figure for 'likelihood of cure' at the individual patient level, to the ERASL model.…”

Section: Issues Surrounding the Albi Scorementioning

confidence: 99%

Reply to: Correspondence concerning “Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection”

Chan

Berhane

Cucchetti

et al. 2019

Journal of Hepatology

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Liver Transplantation and Hepatic Resection can Achieve Cure for Hepatocellular Carcinoma

Abstract: As other malignancies, statistical cure can occur for HCC, primarily with LT and secondarily with HR, depending on waiting-list capabilities and efficacy of tumor recurrence therapies after resection.

Cited by 141 publications

References 30 publications

Validation of the Eighth Edition Clinical T Categorization System for Clinical Stage IA, Resected Lung Adenocarcinomas: Prognostic Implications of the Ground-Glass Opacity Component

Validation of the Eighth Edition Clinical T Categorization System for Clinical Stage IA, Resected Lung Adenocarcinomas: Prognostic Implications of the Ground-Glass Opacity Component

Recent advances in liver transplantation for cancer: The future of transplant oncology

Reply to: Correspondence concerning “Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection”

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