Liver Resection for Hepatocellular Carcinoma on Cirrhosis

Ercolani, Giorgio; Grazi, Gian Luca; Ravaioli, Matteo; Gaudio, Massimo Del; Gardini, Andrea Casadei; Cescon, Matteo; Varotti, Giovanni; Cetta, Francesco; Cavallari, Antonino

doi:10.1097/01.sla.0000059988.22416.f2

Cited by 274 publications

(78 citation statements)

References 31 publications

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“…Tumor recurrence complicates 70% of cases at 5 years, reflecting either intrahepatic metastases (true recurrences) or the development of de novo tumors [31,[52][53][54][55][56][57][58]. These entities can be differentiated by means of comparative genomic hybridization, integration pattern of hepatitis B virus, DNA fingerprinting using loss of heterozygosity assays, or DNA microarray studies [64][65][66].…”

Section: Adjuvant Treatments To Prevent Recurrencementioning

confidence: 98%

“…The main predictors of survival and recurrence after resection are summarized in Table 2 [11,31,[52][53][54][55][56][57][58]. The refinement of assessment of liver function has moved from the gross determination of Child-Pugh class to a more sophisticated measurement of indocyanine green retention rate at 15 min (ICG15) in Japan [59], or hepatic venous pressure gradient (HVPG) P10 mmHg as a direct measurement of relevant portal hypertension in the West [60].…”

Section: Resectionmentioning

confidence: 99%

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Novel advancements in the management of hepatocellular carcinoma in 2008

Llovet¹,

Bruix²

2008

Journal of Hepatology

764

538

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Section: Adjuvant Treatments To Prevent Recurrencementioning

confidence: 98%

Section: Resectionmentioning

confidence: 99%

Novel advancements in the management of hepatocellular carcinoma in 2008

Llovet¹,

Bruix²

2008

Journal of Hepatology

764

538

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“…Long-term survival remains poor due to the high incidence of intrahepatic ROD, which occurs (at 5 years) in 60 -100% of patients treated with surgical resection (5). By contrast, the prevalence of ROD after OLT is much lower, and the 5-year survival rate is Ͼ70% (6,7).…”

Section: Introductionmentioning

confidence: 97%

Predictive Value of Biological Markers for Hepatocellular Carcinoma Patients Treated with Orthotopic Liver Transplantation

Fiorentino¹,

Altimari²,

Ravaioli

et al. 2004

Clinical Cancer Research

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Purpose: To help stratify candidates with hepatocellular carcinoma (HCC) for orthotopic liver transplantation (OLT), biomarkers are needed that are capable of predicting recurrence of disease (ROD). We investigated the prognostic role in this setting of immunohistochemical markers reported previously to predict poor prognosis in HCC patients treated with resection.Experimental Design: Eighty-three patients with HCC who underwent OLT between 1987 and 2001 with a minimum clinical follow up of 12 months were included in this retrospective study. We analyzed immunohistochemical expression of the adhesion molecules E-cadherin and ␤-catenin (membrane/nuclear localization), MIB-1 proliferative index and the cyclin-dependent kinase inhibitor p27, alongside the main clinical-pathological variables.Results: At univariate analysis, vascular thrombosis, high MIB-1 index, lower membrane expression of Ecadherin and ␤-catenin, and nuclear ␤-catenin localization were associated with ROD. At multivariate analysis, only MIB-1 index, low equal E-cadherin (with respect to nonneoplastic surrounding tissue), and nuclear ␤-catenin appeared as independent predictors of ROD. The logistic regression analysis model indicated that detection of any one parameter was associated with at least 88% estimated risk of ROD (up to 99% for all three). Conclusions:We propose these three molecular parameters as an additional tool for rational selection of OLT candidates among HCC patients (stratification according to the risk of ROD might help provide a similar life expectancy for cirrhotic candidates with and without HCC).

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“…There have been correlative studies exploring the prognostic factors of HCC recurrence after curative resection [15,16]. Among those clinicopathological factors, characteristics representing pathological invasiveness are the most consistent indicator of long-term prognosis.…”

Section: Discussionmentioning

confidence: 99%

Influence of surgical resection of hepatocellular carcinoma(HCC) for hematogenous dissemination of HCC cells and its effect on recurrence and metastasis: 3 years prospective study

Liu¹,

Wang²,

Dingi³

et al. 2015

neo

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Aims was to study whether hepatal surgery leads to hematogenous dissemination of hepatocellular carcinoma (HCC) cells and determine period of its persistence by nested reverse transcription-polymerase chain reaction (RT-PCR).Peripheral vein blood (5ml) samples were obtained from 54 HCC patients of T 1 N 0 M 0 and 6 HCC patients of T 2 N 0 M 0 stage and 20 patients with liver cavernous hemangioma(LCH) before operation and 48h, 72h and 1 week after surgical resection of hepatoma between Janurary 1 st , 2007 and December 31th, 2010. We detected alpha-fetoprotein (AFP) messenger RNA(mRNA) by nested RT-PCR perioperatively.AFPmRNA of all 60 cases of HCC patients and 20 cases of LCH were negative before hepatal surgery, 28 of 60 HCC cases became positve at 48h after surgery (46.7%), 16 of 60 HCC cases remained positive at 72h postoperatively(26.7%), none of 60 HCC patients AFPmRNA was detected at 1 week after hepatal surgery(0.0%). None of LCH patients were detected AFPmRNA after hepatal surgery(0.0%). For 28 HCC patients with AFPmRNA positive after hepatal surgery, 4 HCC patients developed intrahepatic tumor recurrences in 1st year (4/28, 14.3%), 6 HCC patients relapsed in the second year(6/28, 21.4%), 10 HCC patients relapsed in the third year(10/28, 35.7%). For 32 HCC patients with AFPmRNA negative group postoperation, 5 cases relapsed in 1st year (5/32, 15.6%), 7 cases developed intrahepatic tumor recurrences in the second year (7/32, 21.9%), 11 cases relasped in the third year (11/32, 34.4%, P>0.05), none of HCC patients occured distal metastasis after surgical resection of hepatoma. None of LCH patients relapsed postoperation within three years.Hepatal surgery may cause HCC cells spreading into peripheral blood shortly, but it may be not concerning with recurrence or metastasis of HCC.

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Liver Resection for Hepatocellular Carcinoma on Cirrhosis

Cited by 274 publications

References 31 publications

Novel advancements in the management of hepatocellular carcinoma in 2008

Novel advancements in the management of hepatocellular carcinoma in 2008

Predictive Value of Biological Markers for Hepatocellular Carcinoma Patients Treated with Orthotopic Liver Transplantation

Influence of surgical resection of hepatocellular carcinoma(HCC) for hematogenous dissemination of HCC cells and its effect on recurrence and metastasis: 3 years prospective study

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