Liver Resection for Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: a Multicenter Propensity Matching Analysis with HBV-HCC

Yang, Tian; Hu, Lunyang; Li, Zhenli; Liu, Kai; Wu, Han; Xing, Hao; Lau, Wan Yee; Pawlik, Timothy M.; Zeng, Yongyi; Zhou, Ya-Hao; Gu, Wei‐Min; Wang, Hong; Chen, Ting‐Hao; Han, Jun; Li, Chao; Wang, Mingda; Wu, Mengchao

doi:10.1007/s11605-018-04071-2

Cited by 37 publications

(45 citation statements)

References 38 publications

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“…NAFLD has become a developing public health problem in recent years and dramatically elevated worldwide 13 . A higher percentage was demonstrated than previous studies which found that 51.34% of NAFLD patients were suffering from obesity and 22.51% suffering from diabetes type 2.Beside,the lower percentage was demonstrated than previous studies which found that suffering from dyslipidemia and hypertension were 69.16 % and 39.34% respectively 14 .Although in NAFLD patients were usually nonspecific their symptom.…”

Section: Discussionmentioning

confidence: 99%

Relationship between G3BP and R4BP with Some Biochemical Parameters in Iraqi Patients with Nonalcoholic Fatty Liver Disease

Hassan,

Dawood,

Hussein

2021

MLU

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nonalcoholic fatty liver disease starts with liver fat accumulation which is a dangerous factor for disease progression. So, we aimed to determine some biochemical parameters among patients with NAFLD and healthy individuals. Sixty patients with NAFLD and thirtyhealthy control who were attending Gastroenterology and Hepatology Teaching Hospital/Baghdad during the period from August /2019 to March /2020. Which included age, sex, BMI, and abdominal ultrasound result with other medical information. Then all the biochemical test is done by Autoanalyzer, while serum galectin 3 binding protein andserum retinol 4 binding protein measured using ELISAtechnique.Our study found that obesity (70%) and dyslipidemia (50%) were more common in patients with NAFLD than other metabolic diseases. NAFLD subjects showa highly significant elevated (p=0.000) in the mean ± SD of BMI, FBS, HbA1, ALP, triglyceride, VLDL, GGT, and G3BP comparedto the healthy controls. Also,serum ALT, total bilirubin, cholesterol, and RBP4 were highly significantly elevated (p=0.001) in the mean ± SD of NAFLD when compared tomean± SD of healthy control.However, it revealed a significant raise (P=0.027) in the mean ± SD of the serum albumin in the NAFLD patients when compared to the mean ± SD of the healthy control and a significant elevated (P=0.002)in the mean ± SD of the LDL in the NAFLD patients and healthy control. But showed a significant decrease (P=0.029) in the mean ± SD of the serum HDL of the NAFLD patient when compared tothe mean ± SD of the healthy control.Finally, we found that the optimal cut-off value for GGT was >25 IU/l with sensitivity and specificity (93.33% and 70%) respectively and RBP4 has an optimal cut-off value >22.28 ng/ ml with sensitivity and specificity (83.33% and 56.67 %) respectively. Therefore, the optimal cut-off value was > 9.49 ng/ml for G3BP with sensitivity and specificity (93.33 % and 83.33% ) respectively.

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Section: Discussionmentioning

confidence: 99%

Relationship between G3BP and R4BP with Some Biochemical Parameters in Iraqi Patients with Nonalcoholic Fatty Liver Disease

Hassan,

Dawood,

Hussein

2021

MLU

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“…Given that NAFLD-associated HCC patients have shown similar recurrence-free survival as other etiology-related HCC, it is conceivable that the recurrence rate is quite high. 13,14 If the recurrence rate is so high, how long and how often should we follow up on HCC patients without established risk factors? To date, there has been a lack of guidelines on the follow-up strategies for HCC cases from any etiology.…”

Section: Dear Editormentioning

confidence: 99%

How long should physicians follow up with patients after curative treatment for hepatocellular carcinoma?

Kim

2020

Clin Mol Hepatol

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“…The primary risk factors include liver cirrhosis, viral hepatitis, alcohol intake, and obesity [ 53 ]. Worldwide, approximately 50% HCC patients are infected with hepatitis B virus (HBV) [ 54 , 55 ] or HCV [ 56 , 57 ]. In addition, alcohol abuse is a crucial factor for onset of HCC [ 58 – 60 ].…”

Section: Overview Of Hccmentioning

confidence: 99%

Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications

Zou

Yuan

2020

Med Sci Monit

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The latest statistics show that rates of morbidity and mortality for hepatocellular carcinoma are gradually increasing over time. Accumulating evidence indicates that circular RNAs (circRNAs) participate in the regulation of gene transcription and translation and exert a crucial role in endogenous RNA network. circRNAs are implicated in the pathogenesis of numerous tumors including hepatocellular carcinoma (HCC), gastric carcinoma and bladder cancer. Of note, the effect of circRNAs in HCC has drawn increasing public attention. Previous studies revealed that the function of circRNAs mainly consists of sponges of miRNA and RNA-binding proteins, alternative splicing of pre-mRNAs, transcriptional and translational regulators, and potential to encode proteins. In addition, recent research data indicate that the expression level of circRNAs is closely correlated with metastasis, invasion, and occurrence of HCC in patients. These findings imply that circRNAs may be useful as biomarkers for diagnosis and prediction of prognosis of HCC. In this review, we have systemically summarized current viewpoints regarding the role of circRNAs expression in HCC to provide an important reference illustrating the underlying mechanism of HCC.

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Liver Resection for Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: a Multicenter Propensity Matching Analysis with HBV-HCC

Cited by 37 publications

References 38 publications

Relationship between G3BP and R4BP with Some Biochemical Parameters in Iraqi Patients with Nonalcoholic Fatty Liver Disease

Relationship between G3BP and R4BP with Some Biochemical Parameters in Iraqi Patients with Nonalcoholic Fatty Liver Disease

How long should physicians follow up with patients after curative treatment for hepatocellular carcinoma?

Current Status of Research on the Role of Circular RNAs in Hepatocellular Carcinoma and Clinical Implications

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