Liver Fibrosis: Noninvasive Assessment with MR Elastography versus Aspartate Aminotransferase–to-Platelet Ratio Index

Huwart, Laurent; Sempoux, Christine; Salameh, Najat; Jamart, Jacques; Annet, Laurence; Sinkus, Ralph; Peeters, Frank; Beek, Leon C. ter; Horsmans, Yves; Beers, Bernard E. Van

doi:10.1148/radiol.2452061673

Cited by 351 publications

(292 citation statements)

References 49 publications

Supporting

Mentioning

265

Contrasting

Unclassified

Order By: Relevance

“…The theoretical advantages of these methods include the ability to analyze almost the entire liver and the applicability to patients with obesity or ascites. Preliminary studies in human subjects have confirmed the feasibility of these techniques for quantitative assessment of hepatic fibrosis [115][116][117][118][119]. In addition, a recent prospective comparative study in 96 patients with chronic liver disease [120] has suggested that MR elastography had a better diagnostic accuracy than TE for the diagnosis of significant fibrosis (AUROC: 0.99 vs. 0.84, respectively P \ 0.05).…”

Section: Novel Imaging Techniquesmentioning

confidence: 90%

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Castéra

2011

Hepatol Int

View full text Add to dashboard Cite

Section: Novel Imaging Techniquesmentioning

confidence: 90%

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Castéra

2011

Hepatol Int

View full text Add to dashboard Cite

“…8 A subsequent prospective comparison of MRE with APRI showed superiority for MRE in liver fibrosis staging. 135 Another study showed that MRE could discriminate between advanced fibrosis (METAVIR F2-F4) and mild fibrosis with a sensitivity of 86% and specificity of 85%. 136 …”

Section: Magnetic Resonance Elastographymentioning

confidence: 99%

Diagnosis and Quantitation of Fibrosis

2008

View full text Add to dashboard Cite

“…Other elastograms acquired in this study appear similar with regard to anatomical features and resolution. In contrast to the classic display of elastograms in MRE [12,13,32], the maps of mechanical parameters in • " Fig. 3 are not masked for excluding noise or regions of unreliably reconstructed parameters.…”

mentioning

confidence: 99%

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Guo

Hirsch

Streitberger

et al. 2013

Fortschr Röntgenstr

View full text Add to dashboard Cite

Purpose: To introduce a novel in-vivo three-dimensional multifrequency magnetic resonance elastography (3D-MMRE) method for high-resolution mechanical characterization of the liver and spleen. Materials and Methods: Ten healthy volunteers were examined by abdominal single-shot 3D-MMRE using a novel patient-activated trigger system with respiratory control. 10 contiguous slices with 2.5?mm cubic voxel resolution, 3 wave components, 8 time steps, and 2 averages were acquired at 7 mechanical excitation frequencies from 30 to 60?Hz. The total imaging time was approximately 15?min. For postprocessing, multifrequency dual elasto-visco (MDEV) inversion was used to calculate high-resolution mechanical parameter maps of the abdomen including the liver and spleen. Results: Two parameters maps were generated from each image slice to capture the magnitude and the phase angle of the complex shear modulus. Both parameters depicted the mechanical structures of the abdomen with unprecedented high spatial resolution. Spatially averaged group mean values of the liver and spleen are 1.27???0.17 kPa and 2.01???0.69 kPa, indicating a significantly higher asymptomatic stiffness of the spleen compared to the liver. Conclusion: Patient-activated respiratory-gated 3D-MMRE combined with MDEV inversion provides highly resolved mechanical maps of the liver and spleen that are superior to previous elastograms measured by abdominal MRE. Citation Format: ??Guo J, Hirsch S, Streitberger KJ et?al. Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen. Fortschr R?ntgenstr 2014; 186: 260???266

show abstract

Liver Fibrosis: Noninvasive Assessment with MR Elastography versus Aspartate Aminotransferase–to-Platelet Ratio Index

Abstract: Large A(z) values for elasticity (>0.990 for scores > or = F2, > or = F3, and F4) show that MR elastography was accurate in liver fibrosis staging and superior to biochemical testing with APRIs.

Cited by 351 publications

References 49 publications

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Diagnosis and Quantitation of Fibrosis

Patient-Activated Three-Dimensional Multifrequency Magnetic Resonance Elastography for High-Resolution Mechanical Imaging of the Liver and Spleen

Contact Info

Product

Resources

About