Liver Elastography in Acute Cellular Rejection After Liver Transplantation

Nacif, Lucas Souto; Gomes, C.d.C.; Paranaguá‐Vezozzo, Denise Cerqueira; Cassenote, Alex Jones Flores; Pinheiro, Rafael Soares; Waisberg, Daniel Reis; Rocha-Santos, Vinícius; Martino, Rodrigo; Arantes, Rubens Macedo; Ducatti, Liliana; Haddad, Luciana; Galvão, Flávio Henrique Ferreira; Andraus, Wellington; Carrilho, Flair José; D’Albuquerque, Luiz Carneiro

doi:10.1016/j.transproceed.2020.02.026

Cited by 8 publications

(8 citation statements)

References 7 publications

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“…Depending on the clinical context, these increments could lead to misinterpretation of the results. Six of our patients were assessed in the early postoperative period after transplantation (< 1 month after LTX), when elevation of liver stiffness can be a sign of acute rejection, inflammation, or hepatic outflow obstruction [5][6][7][8][9][10]. Four children prone to chronic changes like post-transplant fibrosis or chronic rejection associated with increased elastography values were evaluated during the later follow-up phase [5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…Six of our patients were assessed in the early postoperative period after transplantation (< 1 month after LTX), when elevation of liver stiffness can be a sign of acute rejection, inflammation, or hepatic outflow obstruction [5][6][7][8][9][10]. Four children prone to chronic changes like post-transplant fibrosis or chronic rejection associated with increased elastography values were evaluated during the later follow-up phase [5][6][7][8][9][10]. Quantitative longitudinal measurements of liver stiffness are seen as especially useful for monitoring disease activity in a variety of disorders including liver transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasound elastography is used widely to quantitatively assess liver stiffness, and normal values for adults and children have been published [1][2][3]. Many centers have included ultrasound elastography in standardized protocols for patient follow-up after liver transplantation [4,5], as this modality enables the noninvasive determination of the degree of fibrosis and identification of acute allograft damage such as rejection, infection, and hepatic outflow obstruction [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Impact of probe-induced abdominal compression on two-dimensional shear wave elastography measurement of split liver transplants in children

Groth

Fischer

Herden

et al. 2023

Rofo

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Purpose To evaluate the effect of probe-induced abdominal compression of split liver transplants (SLT) in children on 2D-shear wave elastography (SWE) values. Materials and Methods Data from 11 children (4.7 ± 4.8 years) who had undergone SLT and SWE were evaluated retrospectively. Elastograms were obtained with probes placed in an epigastric, midline position on the abdominal wall, with no and slight compression, using convex and linear transducers. For each identically positioned probe and condition, 12 serial elastograms were obtained and the SLT diameter was measured. Liver stiffness and degree of SLT compression were compared. Results Slight probe pressure resulted in SLT compression, with a shorter distance between the cutis and the posterior margin of the liver transplant than in the measurement with no pressure (curved array, 5.0 ± 1.1 vs. 5.9 ± 1.3 cm, mean compression 15 %± 8 %; linear array, 4.7 ± 0.9 vs. 5.3 ± 1.0 cm, mean compression 12 %± 8 %; both p < 0.0001). The median liver stiffness was significantly greater with slight pressure than with no pressure (curved transducer, 13.38 ± 3.0 vs. 7.02 ± 1.7 kPa, p < 0.0001; linear transducer, 18.53 ± 7.1 vs. 9.03 ± 1.5 kPa, p = 0.0003). Conclusion Slight abdominal compression can significantly increase SWE values in children with left-lateral SLT. To obtain meaningful results and reduce operator dependency in free-hand examinations, probe pressure must be controlled carefully. Key points: Citation Format

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of probe-induced abdominal compression on two-dimensional shear wave elastography measurement of split liver transplants in children

Groth

Fischer

Herden

et al. 2023

Rofo

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“…In general, elastography can be used to differentiate affected tissue (with morphostructural alterations) from normal tissue [21]. This technique has been explored for several clinical purposes and introduced into medical diagnostic routines for speci c uses, such as the evaluation of liver transplantation in humans [22], splenic alterations [20], and characterization of mammary lesions in dogs [23,24].…”

Section: Introductionmentioning

confidence: 99%

Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

Carneiro

Cruz

Gasser

et al. 2022

Preprint

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Background: Canine hip dysplasia is common orthopedic disease in veterinary, characterized by hip instability in puppies and secondary degenerative joint disease in adult. Radiographic examination has been the main diagnostic method of hip dysplasia. Different radiographic studies, in addition to diagnosing joint laxity and degenerative joint disease, facilitate patient screening and selection of optimal treatment. However, radiographs do not allow for the assessment of capsular characteristics and adjacent muscles, which can be thoroughly evaluated using various ultrasound techniques. Radiographic examinations require anesthetic management, often causing discomfort in the patients and an inconvenience to owners. This study aimed to evaluate the accuracy of B-mode ultrasonography and acoustic radiation force impulse elastography in the evaluation of the joint capsule and periarticular musculature of dogs using the classification of the Orthopedic Foundation of Animals (OFA) and the distraction index (DI) in the early and late diagnosis of hip dysplasia. This study sought to propose a protocol for the ultrasonographic evaluation of the structures involved in canine hip movement. Results: Radiographic and ultrasonographic evaluations were performed on 108 hip joints of 54 dogs. Thirty dogs were older than 2 years and 24 were aged between 4 and 10 months. It was verified that an increase in pectineus muscle stiffness (cutoff value >2.77 m/s) by elastography and an increase in the thickness of the joint capsule (cutoff value >0.9 mm) in B-mode ultrasonography, were associated with a distraction index >0.5, with both having a positive correlation. In B-mode ultrasonographic evaluation, the presence of signs of degenerative joint disease, such as irregularities of the cranial edge of the acetabulum and femoral head, were associated with a distraction index >0.5 in canines, with a specificity of 94%. In adult dogs, the findings of degenerative joint disease on ultrasound were associated with a diseased OFA classification (P<0.05). Measurement of the joint capsule >1.10 mm was diagnostic for dysplasia in unhealthy dogs by OFA. Conclusions: Ultrasound can be used as an adjuvant diagnostic modality in the diagnosis of hip dysplasia in association with radiographic evaluation in young and adult animals.

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“…Outro achado bastante útil e ainda sob delineamento de seu posicionamento na tomada de decisão clínica se refere à sua capacidade de detecção de rejeição, bem como correlação com seus graus, como distinção entre as formas leve e moderada/grave (Inoue et al 2009;Crespo et al 2012;Rigamonti et al 2012;Nacif et al 2020 O presente estudo não agregou aumento da morbidade, uma vez que se trata de exame não invasivo realizado à beira leito, aproveitando o jejum fisiológico do paciente, sem mobilização, exigindo mínima exposição do local a ser examinado.…”

Section: Aplicações No Transplante Hepáticounclassified

Elastografia para predizer disfunção primária e perda do enxerto no transplante hepático

Andrade¹

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Liver Elastography in Acute Cellular Rejection After Liver Transplantation

Cited by 8 publications

References 7 publications

Impact of probe-induced abdominal compression on two-dimensional shear wave elastography measurement of split liver transplants in children

Impact of probe-induced abdominal compression on two-dimensional shear wave elastography measurement of split liver transplants in children

Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

Elastografia para predizer disfunção primária e perda do enxerto no transplante hepático

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