Liver Damage From Long-Term Methyltestosterone

Westaby, David; Paradinas, F. J.; Ogle, Susan J.; Randell, John; Murray-Lyon, I M

doi:10.1016/s0140-6736(77)90949-7

Cited by 181 publications

(104 citation statements)

References 13 publications

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“…297,298 These unfavorable hepatic effects do not appear to be associated with transdermal or intramuscular injections. For this The risk of polycythemia…”

Section: Liver Problemsmentioning

confidence: 99%

The benefits and risks of testosterone replacement therapy: a review

Bassil¹,

Alkaade²,

Morley

2009

TCRM

140

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“…297,298 These unfavorable hepatic effects do not appear to be associated with transdermal or intramuscular injections. For this The risk of polycythemia…”

Section: Liver Problemsmentioning

confidence: 99%

The benefits and risks of testosterone replacement therapy: a review

Bassil¹,

Alkaade²,

Morley

2009

TCRM

140

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“…Androgens can cause masculinization of the female fetus [66,67] and thus are contraindicated during pregnancy. Androgens, particularly the 17-alpha alkylated androgens, may have hepatic side effects, including cholestatic jaundice [68], peliosis hepatis [69] and hepatocellular adenoma [70][71][72][73]. The observed cases of hepatocellular adenomas developing in patients with C1 INH deficiency on long-term prophylaxis with danazol have caused particular concern [74] (evidence level 3).…”

Section: Attenuated Androgensmentioning

confidence: 99%

C1 inhibitor deficiency: consensus document

Gompels

Lock

Abinun

et al. 2005

Clinical and Experimental Immunology

379

460

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SummaryWe present a consensus document on the diagnosis and management of C1 inhibitor deficiency, a syndrome characterized clinically by recurrent episodes of angio-oedema. In hereditary angio-oedema, a rare autosomal dominant condition, C1 inhibitor function is reduced due to impaired transcription or production of non-functional protein. The diagnosis is confirmed by the presence of a low serum C4 and absent or greatly reduced C1 inhibitor level or function. The condition can cause fatal laryngeal oedema and features indistinguishable from gastrointestinal tract obstruction. Attacks can be precipitated by trauma, infection and other stimulants. Treatment is graded according to response and the clinical site of swelling. Acute treatment for severe attack is by infusion of C1 inhibitor concentrate and for minor attack attenuated androgens and/or tranexamic acid. Prophylactic treatment is by attenuated androgens and/or tranexamic acid. There are a number of new products in trial, including genetically engineered C1 esterase inhibitor, kallikrein inhibitor and bradykinin B2 receptor antagonist. Individual sections provide special advice with respect to diagnosis, management (prophylaxis and emergency care), special situations (childhood, pregnancy, contraception, travel and dental care) and service specification.

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“…Androgens can cause masculinisation of the female fetus 51 52 and thus are not recommended during pregnancy. The most worrying effects of all the 17α-alkylated androgens, including danazol and stanazolol, are those on liver metabolism, in particular cholestatic jaundice, 53 peliosis hepatis, 54 and hepatocellular carcinoma. [55][56][57][58] The recently observed first cases of hepatocellular adenomas developing in patients with HAE on long term prophylaxis with danazol have caused particular concern.…”

Section: Long Term Prophylaxismentioning

confidence: 99%