Liver cell swelling leads to upregulation of miR-141-3p in perfused rat liver and primary rat hepatocytes

Bardeck, Nils; Paluschinski, Martha; Castoldi, Mirco; Luedde, Tom; Häussinger, Dieter; Dahl, Stephan Vom; Schöler, David

doi:10.1055/s-0040-1721965

Cited by 3 publications

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“…Набухание гепатоцитов увеличивает экскрецию желчи и имеет гепатопротективный эффект [24], вызывает анаболический ответ, считается своеобразным триггером, запускающим подавление пролиферации при регенерации клеток печени [25].…”

Section: Discussionunclassified

The effect of chronic alcohol intoxication and constant illumination on the morphological and functional state of the liver

Kirillov¹,

Kozlova²,

Makartseva³

et al. 2021

Clin. Exp. Morphology

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Introduction. Alcohol abuse is one of major health and social problems of modern society, the essence of which is an increase in morbidity and mortality not only from alcohol misuse and its complications, but also from associated comorbid pathologies. The liver is the organ that is affected most by ethanol and its metabolites. A significant factor leading to melatonin-associated morphological manifestations in the liver is the so-called light pollution, a violation of the light–dark regime. At the same time, heavy consumption of alcohol over a short period of time (alcoholic excesses) and other forms of alcoholic illness are often associated with various sleep disorders. The aim of the study was to investigate the morphological and functional state of the liver of Wistar rats under experimental alcohol intoxication in conditions of a fixed light regime and constant illumination. Materials and methods. Male rats (n=160) were kept under a fixed light regime, constant illumination, and at a combination of both light regimes with simultaneous experimental alcohol intoxication. We performed a pathological examination of the liver and determined morphometric parameters, hepatocyte ploidy, and the proportion of binuclear hepatocytes. Results. The consumption of 15% ethanol solution as a drink ad libitum for 3 weeks at a fixed light regime causes the development of fatty degeneration in the liver of laboratory animals. Secondary to it, changing lighting from fixed to constant is accompanied by the development of alcoholic hepatitis in about half of the animals. The results of micromorphometry indicate significant changes in the studied parameters of hepatocytes, which are expressed least of all in the case of ethanol consumption under fixed lighting condi-tions and affect most the cells of the liver parenchyma of rats with chronic alcohol intoxication secondary to constant lighting. Conclusion. Alcohol intoxication that occurs secondary to a melatonin deficiency caused by constant lighting is accompanied by a much greater severity, prevalence, and intensity of inflammatory tissue reactions and a variety of manifestations of liver pathology. Keywords: hepatocyte, alcohol, lighting regime, stress, fatty degeneration

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Section: Discussionunclassified

The effect of chronic alcohol intoxication and constant illumination on the morphological and functional state of the liver

Kirillov¹,

Kozlova²,

Makartseva³

et al. 2021

Clin. Exp. Morphology

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show abstract

“…Notable hepatocyte hypertrophy can be seen in all individuals exposed to constant light within three weeks. The noted decrease in the proportion of binuclear hepatocytes in the experimental group can be explained by the fact that al-most all cell divisions produced daughter mononuclear cells, regardless of the number of nuclei in mother hepatocytes [31]. At the same time, processes of compensatory cell hypertrophy are the signs of liver regeneration and compensatory changes seen in stressful conditions [32].…”

Section: ключевые слова: гепатоцит печень микроморфометрия постоянное...mentioning

confidence: 91%

The Influence of the Constant Illumination on the Ultrastructure of Rat's Hepatocytes

2023

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Influence of constant lightning on liver health: an experimental study

Areshidze

Kozlova

Makartseva

et al. 2022

Environ Sci Pollut Res

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Liver cell swelling leads to upregulation of miR-141-3p in perfused rat liver and primary rat hepatocytes

Cited by 3 publications

References 0 publications

The effect of chronic alcohol intoxication and constant illumination on the morphological and functional state of the liver

The effect of chronic alcohol intoxication and constant illumination on the morphological and functional state of the liver

The Influence of the Constant Illumination on the Ultrastructure of Rat's Hepatocytes

Influence of constant lightning on liver health: an experimental study

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