Liver Cell Adenoma: A Multicenter Analysis of Risk Factors for Rupture and Malignancy

Deneve, Jeremiah L.; Pawlik, Timothy M.; Cunningham, Steve; Clary, Bryan M.; Reddy, Srinevas K.; Scoggins, Charles R.; Martin, Robert C.G.; D’Angelica, Michael I.; Staley, Charles A.; Choti, Michael A.; Jarnagin, William R.; Schulick, Richard D.; Kooby, David A.

doi:10.1245/s10434-008-0275-6

Cited by 189 publications

(170 citation statements)

References 34 publications

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“…(4)(5)(6)(7)(8)(9)(10) However, this surgical approach can be difficult or impossible in cases of LA due to the large number of adenomas. Therefore, liver transplantations (LTs) have been reported in the literature.…”

Section: Liver Transplantation 22 516-526 2016 Aasldmentioning

confidence: 99%

Liver transplantation for adenomatosis: European experience

et al. 2016

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The aim of this study was to collect data from patients who underwent liver transplantation (LT) for adenomatosis; to analyze the symptoms, the characteristics of the disease, and the recipient outcomes; and to better define the role of LT in this rare indication. This retrospective multicenter study, based on data from the European Liver Transplant Registry, encompassed patients who underwent LT for adenomatosis between January 1, 1986, and July 15, 2013, in Europe. Patients with glycogen storage disease (GSD) type IA were not excluded. This study included 49 patients. Sixteen patients had GSD, and 7 had liver vascular abnormalities. The main indications for transplantation were either a suspicion of hepatocellular carcinoma (HCC; 15 patients) or a histologically proven HCC (16 patients), but only 17 had actual malignant transformation (MT) of adenomas. GSD status was similar for the 2 groups, except for age and the presence of HCC on explants (P = 0.030). Three patients with HCC on explant developed recurrence after transplantation. We obtained and studied the pathomolecular characteristics for 23 patients. In conclusion, LT should remain an extremely rare treatment for adenomatosis. Indications for transplantation primarily concern the MT of adenomas. The decision should rely on morphological data and histological evidence of MT. Additional indications should be discussed on a case‐by‐case basis. In this report, we propose a simplified approach to this decision‐making process.

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Section: Liver Transplantation 22 516-526 2016 Aasldmentioning

confidence: 99%

Liver transplantation for adenomatosis: European experience

et al. 2016

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“…9,10 Although HCAs are benign, lesions larger than 5 cm have a relatively high risk of bleeding (25-40%) and an estimated risk of malignant transformation of approximately 5 per cent. [11][12][13] For these lesions elective resection is generally accepted as treatment of choice and can be performed both through an open or laparoscopic approach.…”

Section: Introductionmentioning

confidence: 99%

Long-term outcomes of resection in patients with symptomatic benign liver tumours

Rosmalen

Bieze

Besselink

et al. 2016

HPB

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“…The main complications of HA are rupture, hemorrhage and malignant transformation, the incidence of which increase with increasing adenoma size. 8,9 For giant HAs, surgical excision at an experienced liver surgery unit is the gold standard treatment option. 1 Our literature review also indicates that this is the first report of HA in siblings.…”

Section: Discussionmentioning

confidence: 99%

Synchronous giant hepatic adenoma in siblings-A case report and brief literature review

Zhang

Shi

Zhao

2016

Cancer Biology & Therapy

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A 47-year-old woman was referred to our department for a hepatic mass. She denied history of hepatitis or alcohol consumption and regular oral contraceptive use, except for the emergency contraceptive pill taken once a decade ago. Hepatitis B surface antigen and anti-hepatitis C antibody were negative, a-fetoprotein was within normal limit. CT scan revealed an enormous mass measuring 26.0£16 5£13 0 cm that almost totally replaced the right hepatic lobe. The neoplasm was completely resected and pathologically diagnosed as hepatic adenoma. Literature review indicates this is the largest hepatic adenoma reported so far. At the same time, clinical examination also revealed a hepatic mass in the patient's 42-year-old brother, which was pathologically confirmed as hepatic adenoma, too. He denied history of anabolic steroid use. Immunohistochemical analysis revealed the subtypes of both tumors as the inflammatory hepatic adenoma. Literature review indicates this is the first report of synchronous hepatic adenomas in siblings.

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Liver Cell Adenoma: A Multicenter Analysis of Risk Factors for Rupture and Malignancy

Cited by 189 publications

References 34 publications

Liver transplantation for adenomatosis: European experience

Liver transplantation for adenomatosis: European experience

Long-term outcomes of resection in patients with symptomatic benign liver tumours

Synchronous giant hepatic adenoma in siblings-A case report and brief literature review

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