Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta‐analysis

Jena, Anuraag; Kumar‐M, Praveen; Kumar, Akhil; Birda, Chhagan Lal; Choudhury, Arup; Kumar, Naveen; Ramai, Daryl; Facciorusso, Antonio; Samanta, Jayanta

doi:10.1111/jgh.16039

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…Формирование ГТ может быть результатом включения аутоиммунных процессов, приводящих к повреждению паренхимы печени анти-ТТГ, что подтверждается нормализацией уровней АЛТ и АСТ на фоне строгого соблюдения безглютеновой диеты [9,16,19]. Кроме того, повреждение печени при целиакии может быть обусловлено выработкой антител к гепатоцитам у лиц, имеющих генетическую предрасположенность к формированию аутоиммунных заболеваний.…”

Section: обсуждение результатовunclassified

Liver damage in children and adolescents with newly diagnosed celiac disease: clinical and anamnestic, serological and morphological patterns

Cherkasova¹,

Klimov²,

Kuryaninova³

et al. 2023

Terapevticheskii arkhiv

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Hypertransaminasemia is a common extra-intestinal manifestation of celiac disease. Aim. To analyze the frequency of hypertransaminasemia, clinical and anamnestic, serological and morphological picture in children in the active period of celiac disease. Materials and methods. The study included 272 children with celiac disease aged from 8 months to 17 years. The patients were divided into two groups: the first children with hypertransaminasemia, the second without hypertransaminasemia. Results. Hypertransaminasemia was detected in 55.9% of children with celiac disease. The age of manifestation of the disease in the first group was 1.0 [0.5; 2.0] years, in the second group 1.9 [0.5; 4.0] years (p=0.0004). Children of the first group were diagnosed at 2.5 [1.7; 4.9] years, the second group at 4.9 [3.0; 10.8] years (p0.001). The duration of the latency period in children of the first and second groups was 1.4 [0.6; 3.1] years and 2.4 [0.9; 4.3] years, respectively (p=0.002). The average values of IgA anti-tTG antibodies in children of the analyzed groups did not differ, and the indicators of IgG anti-tTG antibodies in the first group were 1.6 (p=0.04) times higher. The level of EMA in children with hypertransaminasemia was 2 times higher than in children without hypertransaminasemia. Conclusion. Hypertransaminasemia is more often detected in young children with early manifestation of the disease, increases with the deepening of atrophy in the mucous membrane of the small intestine. Higher titers of celiac-specific antibodies were detected in children with hypertransaminasemia.

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Section: обсуждение результатовunclassified

Liver damage in children and adolescents with newly diagnosed celiac disease: clinical and anamnestic, serological and morphological patterns

Cherkasova¹,

Klimov²,

Kuryaninova³

et al. 2023

Terapevticheskii arkhiv

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Single-Center Analysis of Essential Laboratory Testing in Patients with Newly Diagnosed Celiac Disease

Farmer¹,

Boyle²,

Hill³

et al. 2023

The Journal of Pediatrics

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Incidentally Discovered Cryptogenic Cirrhosis in a Patient with Untreated Celiac Disease

Kosako Yost,

Alishahi

2023

Galician med. j.

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Celiac disease is a common gastrointestinal disorder that primarily manifests its effects on the small bowel. However, the systemic nature of this condition, especially regarding the liver, has been gaining some recognition in the literature. Mild liver disease is common, but few cases progress to cirrhosis. We present a case of an asymptomatic 78-year-old male with a past medical history of longstanding celiac disease, atrial fibrillation, heart failure with preserved ejection fraction, type 2 diabetes mellitus (DM), and chronic kidney disease stage III who underwent a computed tomography (CT) scan for thoracic aortic aneurysm surveillance. Incidentally, on a CT scan, cirrhotic liver morphology was discovered. Right upper quadrant ultrasound confirmed heterogenous echotexture of the liver, consistent with a diagnosis of cirrhosis. Laboratory work-up demonstrated elevated alkaline phosphatase of 171, tissue transglutaminase (TTG) significantly elevated at > 100, and a negative panel of other chronic liver disease labs, including negative anti-smooth muscle antibody, antimitochondrial antibody, liver kidney microsomal antibody, HFE gene, ceruloplasmin, alpha-1-antitrypsin, and alpha-fetoprotein < 2 ng/mL. The patient was not taking any hepatotoxic medications. Although the patient did have type 2 DM, his hemoglobin A1c was well-controlled at 5.9%, and he had no hyperlipidemia and a normal body mass index, making a metabolic etiology of liver disease less likely. The patient had no significant alcohol use, either. The only patient’s major risk factor for liver disease was his untreated celiac disease, diagnosed in infancy. The patient was instructed to avoid any gluten, alcohol, and other hepatotoxic substances and was subsequently followed by a gastroenterologist. The following case report explores the pathogenesis of celiac-associated liver disease and the effect a gluten-free diet can have on the small bowel and the liver.

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Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta‐analysis

Cited by 3 publications

References 65 publications

Liver damage in children and adolescents with newly diagnosed celiac disease: clinical and anamnestic, serological and morphological patterns

Liver damage in children and adolescents with newly diagnosed celiac disease: clinical and anamnestic, serological and morphological patterns

Single-Center Analysis of Essential Laboratory Testing in Patients with Newly Diagnosed Celiac Disease

Incidentally Discovered Cryptogenic Cirrhosis in a Patient with Untreated Celiac Disease

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