Livedo vasculitis with protein C system deficiency

Cutaneous ulcers: An unusual manifestation of inherited thrombophilia

“…In contrast to previous reports, where, despite the underlying thrombophilia, treatment with warfarin has not been effective for the management of cutaneous ulcers [3,6], in our first case, response to asenocoumarol was dramatic, with complete healing of the necrotic skin lesions. In our second patient, due to the absence of a major thrombotic effect, the patient was placed on aspirin with complete resolution of the lesions after 6 months.…”

Frequency of thrombophilia determinant factors in patients with livedoid vasculopathy and treatment with anticoagulant drugs – a prospective study

“…Deficiency of these proteins is estimated at 0.2% of the general population and at 4–6% in venous thrombosis patients. Protein C deficiency has been described in patients with LV 26–30 . In our study, three patients were found to have low S‐protein levels, of which one also had C‐protein deficiency.…”

“…Nevertheless, broader studies are necessary to consolidate these findings, clarify their meaning in the pathophysiology of the disease and validate the therapeutic measures. 10,29 Our study not only discloses that the anticoagulation drugs are well tolerated but also points them as a viable and effective therapeutic option for the patients with LV, especially for those with chronic, recurrent and refractory cases.…”

Livedoid Vasculopathy

“…32,33 Protein C deficiency has been found in individuals with livedoid vasculopathy. 34,35 Decreases in the activity of protein C or protein S were detected in 1 patient each in our series.…”