Live Food Mediated Drug Delivery as a Tool for Disease Treatment in Larviculture: A Case Study with Turbot <i>Scophthalmus maximus</i>

Dehasque, Marleen; Sorgeloos, Patrick; Nelis, Hans; Leenheer, A.P. De

doi:10.1111/j.1749-7345.1995.tb00247.x

Cited by 14 publications

(27 citation statements)

References 6 publications

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“…The concentration of TMP/SMX in the brine shrimp obtained here (2-243 mgg~^ dry weight) was 2-6 times higher than the value obtained by Chair et al (1991) (0-876mgg~^ dry weight) with the same input of drug. Chair ef a/.…”

Section: Discussioncontrasting

confidence: 67%

Delivery of quinolone antibacterials to turbot, Scophthalmus maximus (L.), via bioencapsulation: quantification and efficacy trial

Duis

Hammer

Beveridge

et al. 1995

Journal of Fish Diseases

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The incorporation of the quinolone antibacterials oxohnic acid and sarafloxacin into Artemia fransciscana and subsequently into turbot, Scophthalmus maximus (L.), was quantified, and the therapeutic efficacy of the bioencapsulated drugs against challenge with Vibrio anguillarum 8587 was investigated. Five-wcek-oid turbot were fed for 10 days with Artemia enriched with either oxolinic acid or sarafloxaein. Therapeutic concentrations were reached with both drugs (11-8^/g oxolinic acid per gram fresh weight: lK/^g sarafloxacin per gram fresh weight). Both treatments proved effective against challenge, with V. anguillaritmspeeific mortality rates of 6 and 14% in the oxolinic acid and sarafloxaein treated groups, respectively, compared with 75% in the infected control. However, incorporation of the drug by brine shrimp was extremely low (<1%), and therefore, bioencapsulation cannot be considered as an appropriate method to reduce impact on the environment.Correspondence; K. Duis, Fleitberg 2, 23619 Heilshoop. Germany.

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Section: Discussioncontrasting

confidence: 67%

Delivery of quinolone antibacterials to turbot, Scophthalmus maximus (L.), via bioencapsulation: quantification and efficacy trial

Duis

Hammer

Beveridge

et al. 1995

Journal of Fish Diseases

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“…Touraki, Mourelatos, Karamanildou, Kalaitzopoulou & Kastritsis (1996) showed Vibrio anguillarum – challenged sea bass larvae experienced improved survival over the controls when fed Artemia nauplii enriched with trimethoprim – sulphamethoxazole. Turbot larvae fed a commercially available vaccine bioencapsulated in Artemia nauplii showed significant survival over controls when challenged with V. anguillarum (Chair, Dehasque, Sorgeloos, Nelis & De Leenheer 1995). Using adult Artemia as vehicles for antibiotic delivery may also benefit species that are otherwise difficult to treat during late larval and juvenile stages.…”

Section: Introductionmentioning

confidence: 99%

Uptake of erythromycin by first‐feeding sockeye salmon, Oncorhynchus nerka (Walbaum), fed live or freeze‐dried enriched adult Artemia or medicated pellets

Cook

Rust

Massee

et al. 2003

Journal of Fish Diseases

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The potential to use adult Artemia to deliver erythromycin to first-feeding sockeye salmon, Oncorhynchus nerka (Walbaum), was investigated in three trials. In the first trial, first-feeding sockeye were fed live erythromycin enriched adult Artemia or pellets containing equal amounts of erythromycin for 35 days. At the end of the trial, tissue erythromycin concentration of the fish fed the live Artemia was significantly greater (P < 0.05, 25.52 +/- 1.29 microg mL(-1); mean +/- SEM), than the tissue concentration of the fish fed the pellets (0.72 +/- 0.01 microg mL(-1)). In the second trial, first-feeding sockeye were fed either live or freeze-dried bioencapsulated erythromycin (adult Artemia) or pellets containing erythromycin daily for 21 days. Mean daily erythromycin concentration in fish fed the freeze-dried Artemia, live Artemia, or pellets did not differ significantly. In the third trial, apparent erythromycin digestibility was determined. Significantly more (P< 0.05) erythromycin was retained by juvenile sockeye fed freeze-dried bioencapsulated erythromycin (98.3 +/- 1.0%) compared with medicated pellets (89.2 +/- 1.7%). Uptake of bioencapsulated erythromycin from adult Artemia (live or freeze-dried) appears to be greater than uptake from pellets. Freeze-dried and live Artemia were equally effective at delivery suggesting enriched freeze-dried adult Artemia could be produced into a highly palatable, consistent, off-the-shelf product.

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“…have been proposed as vectors for administration of nutrients and chemotherapeutics to marine larvae (Dhert et al, 1990;Chair et al, 1991;Merchie et al, 1995;Roque et al, 1998) and are well suited to this purpose. Bioencapsulation of bacterins in Artemia sp.…”

Section: Introductionmentioning

confidence: 99%

Uptake and processing of a Vibrio anguillarum bacterin in Artemia franciscana measured by ELISA and immunohistochemistry

Bergh

Vikanes

Makridis

et al. 2001

Fish & Shellfish Immunology

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Live Food Mediated Drug Delivery as a Tool for Disease Treatment in Larviculture: A Case Study with Turbot Scophthalmus maximus

Cited by 14 publications

References 6 publications

Delivery of quinolone antibacterials to turbot, Scophthalmus maximus (L.), via bioencapsulation: quantification and efficacy trial

Delivery of quinolone antibacterials to turbot, Scophthalmus maximus (L.), via bioencapsulation: quantification and efficacy trial

Uptake of erythromycin by first‐feeding sockeye salmon, Oncorhynchus nerka (Walbaum), fed live or freeze‐dried enriched adult Artemia or medicated pellets

Uptake and processing of a Vibrio anguillarum bacterin in Artemia franciscana measured by ELISA and immunohistochemistry

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