Live birth in a 50-year-old woman following in vitro fertilization–embryo transfer with autologous oocytes: a rare case report

Is 45 years-of-age the cut-off for using autologous oocytes?

“…The nature of these pregnancies (natural or assisted) is not described. Perhaps the oldest woman achieving a livebirth from autologous oocytes utilising IVF is aged 50 years, documented in the journal Fertility and Sterility by authors from West Bengal, India as a rare case (Rani et al, 2015). However, given the https://doi.org/10.1016/j.rbmo.2018.06.016 1472-6483/© 2018 Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd. rarity of such pregnancies from ART, the report could be treated sceptically given that 50% of births in India still occur at home; birth certificates may not be generated in real time; and the reported case relied on a government-issued voter's card to indicate the woman's age.…”

One thousand seventy-eight autologous IVF cycles in women 45 years and older: the largest single-center cohort to date

“…The only study to further stratify outcomes by age in women > 44 years old was performed at this institution more than a decade ago with a total of 288 patients [6]. IVF pregnancies in women over 45 are limited to isolated case reports and therefore are unable to estimate accurate pregnancy rates to guide practice management [11,12]. To that end, we queried our clinical database to further evaluate pregnancy outcomes in women ≥ 45 years old pursuing IVF with autologous oocytes.…”

The dilemma of counseling patients about poor prognosis: live birth after IVF with autologous oocytes in a 43-year-old woman with FSH levels above 30 mIU/mL

“…While reports of patients conceiving late in life with their own oocytes have recently appeared [8][9][10], elevated FSH levels in women over 40 appear to have a high negative predictive value in estimating subsequent live birth with the patient's own oocytes [11][12][13][14]. In our clinic, women over the age of 40 with menstrual day 3 FSH levels above 20 mIU/mL are advised to repeat the test, but if the results are consistently high, they are offered immediate oocyte donation due to the significant improvement in success rates (>50%) that can be expected compared to using autologous oocytes [15].…”