Live birth from a 46-year-old using fresh autologous oocytes through in vitro fertilization☆

Trolice, Mark P.

doi:10.1016/j.fertnstert.2014.04.014

Cited by 9 publications

(8 citation statements)

References 14 publications

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“…Few of the earlier case studies suggest that IVF treatment should be limited to patients <43 years of age (9), because a reasonable chance for success with homologous oocytes is observed up until the end of the 44th year (10). Limited reports of live births are available in older women from autologous oocytes after IVF-ET (11)(12)(13). The present report discusses the case of a 50-year-old woman who delivered a healthy baby after IVF with her own oocytes.…”

Section: Discussionmentioning

confidence: 99%

Live birth in a 50-year-old woman following in vitro fertilization–embryo transfer with autologous oocytes: a rare case report

Rani

Goswami

Chattopadhyay

et al. 2015

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Live birth in a 50-year-old woman following in vitro fertilization–embryo transfer with autologous oocytes: a rare case report

Rani

Goswami

Chattopadhyay

et al. 2015

Fertility and Sterility

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“…One study of a series of 288 women aged 45 or over to use autologous oocytes demonstrated only livebirth success in women no older than 45 and who produced at least five oocytes [9]. The oldest age at livebirth previously reported was 46 years [14], but from a fresh cycle where 7 oocytes collected and four embryos transferred.…”

Section: Discussionmentioning

confidence: 99%

Treatment and preservation at the extremes of reproductive age: a case report outlining the ethical dilemmas

Nicopoullos

Wren

Abdalla

2015

J Assist Reprod Genet

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Purpose The purpose of the study was to report a livebirth from a cryopreserved embryo created from autologous oocytes collected at 47 years and 9 months that outlines the ethical difficulties of decision-making at the extreme of reproductive age. Methods The method used was IVF and embryo cryopreservation within an assisted conception unit prior to adjuvant cancer treatment in a nulliparous patient diagnosed with breast carcinoma (47 years and 9 months at oocyte collection). Results A 47-year-old nulliparous woman was diagnosed with breast malignancy during work-up for fertility treatment. Ovarian stimulation yielded one embryo from four oocytes that was cryopreserved to allow completion of adjuvant treatment. Subsequent embryo transfer cycle led to a live birth of a healthy baby girl at term, weighing 3.37 kg. Conclusion This paper demonstrates the oldest reported age of autologous oocyte collection to have achieved a livebirth. In women where most would consider treatment futile, we highlight the difficulties in decision-making in this group of patients.

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“…It is interesting to note that reports of pregnancies in women of advanced reproductive age using autologous oocytes have recently appeared [7][8][9]. Many would argue that the ages reported would previously have been considered Bfutile.F ertility treatment success rates are rising every year, and it is possible that treatment that was previously considered futile may simply represent another poor prognosis situation.…”

Section: Commentmentioning

confidence: 99%

“…While reports of patients conceiving late in life with their own oocytes have recently appeared [8][9][10], elevated FSH levels in women over 40 appear to have a high negative predictive value in estimating subsequent live birth with the patient's own oocytes [11][12][13][14]. In our clinic, women over the age of 40 with menstrual day 3 FSH levels above 20 mIU/mL are advised to repeat the test, but if the results are consistently high, they are offered immediate oocyte donation due to the significant improvement in success rates (>50%) that can be expected compared to using autologous oocytes [15].…”

Section: Introductionmentioning

confidence: 99%

The dilemma of counseling patients about poor prognosis: live birth after IVF with autologous oocytes in a 43-year-old woman with FSH levels above 30 mIU/mL

Burks

Baker

Quaas

et al. 2017

J Assist Reprod Genet

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Providing reasonable expectations to patients with diminished ovarian reserve prior to attempting pregnancy through in vitro fertilization (IVF) is one of the most challenging aspects of fertility care. In some instances, advice from the clinician to pursue more effective treatment, such as donor oocytes, may not be acceptable to the patient. In this case report, a patient is presented who represents a poor prognosis candidate for IVF treatment. She was 43 years old with six prior failed IVF cycles and repetitive basal FSH values above 30 mIU/mL. Presented are the challenges in patient counseling and decision making. In her seventh IVF cycle, which she was strongly counseled against pursuing, the patient experienced the desired outcome of live birth. Increasing reports are emerging of live birth using autologous oocytes among women of advanced reproductive age. These instances, as well as the case of our patient, raise issues commonly encountered in patient counseling in poor prognosis patients. This discussion should include an emphasis on patient goals as well as an acknowledgement that no test for ovarian reserve has a 100% positive predictive value.

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Live birth from a 46-year-old using fresh autologous oocytes through in vitro fertilization☆

Abstract: The prognosis for a live birth from IVF in a patient with very advanced reproductive age, particularly with an undetectable AMH level using autologous oocytes, remains extremely poor. This case should be interpreted with caution so as to not provide false hope to women aged 45 and above.

Cited by 9 publications

References 14 publications

Live birth in a 50-year-old woman following in vitro fertilization–embryo transfer with autologous oocytes: a rare case report

Live birth in a 50-year-old woman following in vitro fertilization–embryo transfer with autologous oocytes: a rare case report

Treatment and preservation at the extremes of reproductive age: a case report outlining the ethical dilemmas

The dilemma of counseling patients about poor prognosis: live birth after IVF with autologous oocytes in a 43-year-old woman with FSH levels above 30 mIU/mL

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