Live Attenuated and Inactivated Influenza Vaccines in Children

Ilyushina, Natalia A.; Haynes, Brenda C.; Hoen, Anne G.; Khalenkov, Alexey M.; Housman, Molly L.; Brown, Eric P.; Ackerman, Margaret E.; Treanor, John J.; Luke, Catherine J.; Subbarao, Kanta; Wright, Peter F.

doi:10.1093/infdis/jiu458

Cited by 42 publications

(44 citation statements)

References 20 publications

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“…The absence of an increase in Ab titers among adult recipients of LAIV are consistent with our findings that the A (H1N1)pmd09 LAIV was highly restricted in replication in adults and did not elicit an increase in neutralizing Ab titers (unpublished data). However, it is surprising that the seasonal LAIV did not induce an increase in ADCC-Ab titers in children, despite clear evidence of vaccine virus replication [15]. This may indicate that the antigen load was insufficient to generate classswitched antibodies that mediate ADCC.…”

Section: Discussionmentioning

confidence: 99%

“…Adult and pediatric serum samples were obtained from previously performed studies; all study subjects provided informed consent/assent [15,16]. Sera from vaccinated adults were obtained from the University of Rochester Medical Center.…”

Section: Clinical Samplesmentioning

confidence: 99%

“…Sera from a pediatric vaccine study (clinical trials registration NCT01246999) were obtained from the Geisel School of Medicine at Dartmouth [15]. Children were enrolled between October 2010 and February 2012.…”

Section: Clinical Samplesmentioning

confidence: 99%

“…To further compare ISV and LAIV, we investigated ADCC-Abs in a previously described pediatric cohort [15]. Children received either a dose of seasonal TIV followed by a dose of seasonal LAIV or 2 doses of seasonal LAIV, 28 days apart.…”

Section: Adcc-abs Measured By High-throughput Nk Cell Activationmentioning

confidence: 99%

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Generation and Protective Ability of Influenza Virus–Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge

Luke²,

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Clinical Samplesmentioning

confidence: 99%

Section: Clinical Samplesmentioning

confidence: 99%

Section: Adcc-abs Measured By High-throughput Nk Cell Activationmentioning

confidence: 99%

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Generation and Protective Ability of Influenza Virus–Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge

Luke²,

et al. 2016

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“…Host status can have major effects on vaccineinduced responses. For example, preexisting immunity can inhibit the response to a vaccine that must infect and replicate for optimal immunogenicity (15,16). Furthermore, relative immunodeficiencies can limit optimal vaccine-induced responses and may have a greater effect in reducing responses to IIV with fewer natural adjuvant properties.…”

mentioning

confidence: 99%

Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults

Hoft

Lottenbach

Blazevic

et al. 2017

Clin Vaccine Immunol

114

105

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Both live attenuated influenza vaccines (LAIV) and inactivated influenza vaccines (IIV) induce protective immunity against influenza. There is evidence that LAIV induces superior protection in children, whereas IIV may induce superior protection in adults. The immune mechanisms responsible for these differences have not been identified. We previously compared LAIV and IIV in young children of 6 to 36 months of age, and we demonstrated that while both induced similar hemagglutination inhibition (HAI) antibody responses, only LAIV induced significant increases in T cell responses. In the present study, 37 healthy adult subjects of 18 to 49 years of age were randomized to receive seasonal influenza vaccination with LAIV or IIV. Influenza virus-specific HAI, T cell, and secretory IgA (sIgA) responses were studied pre- and postvaccination. In contrast to the responses seen in young children, LAIV induced only minimal increases in serum HAI responses in adults, which were significantly lower than the responses induced by IIV. Both LAIV and IIV similarly induced only transient T cell responses to replication-competent whole virus in adults. In contrast, influenza virus-specific sIgA responses were induced more strongly by LAIV than by IIV. Our previous studies suggest that LAIV may be more protective than IIV in young children not previously exposed to influenza virus or influenza vaccines due to increased vaccine-induced T cell and/or sIgA responses. Our current work suggests that in adults with extensive and partially cross-reactive preexisting influenza immunity, LAIV boosting of sIgA responses to hemagglutinin (HA) and non-HA antigenic targets expressed by circulating influenza virus strains may be an important additional mechanism of vaccine-induced immunity.

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