Littoral cell angioma of the spleen: CT and MR imaging appearance

Schneider, Günther; Uder, Michael; Altmeyer, K.; Bonkhoff, Helmut; Gruber, M.; Kramann, B.

doi:10.1007/s003300000345

Cited by 29 publications

(11 citation statements)

References 18 publications

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“…On contrast-enhanced CT images, littoral cell angiomas usually present as multiple, ill-defined, hypodense lesions that show prolonged contrast-enhancement due to their histological structure of multiple vascular channels [39–41] (Fig. 12).…”

Section: Littoral Cell Angiomamentioning

confidence: 99%

Computed tomography of the spleen: how to interpret the hypodense lesion

et al. 2012

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BackgroundAs the largest single lymphatic organ in the human body, the spleen is responsible for central immunological and haematological tasks. Therefore, the spleen can be subject to a wide range of pathologic disorders. Computed tomography (CT) represents the most widely applied cross-sectional abdominal imaging technique and is considered the imaging modality of choice for the evaluation of numerous abdominal pathological conditions. Hypodense splenic lesions are frequently encountered on abdominal CT images. Although most hypodense lesions of the spleen can be considered benign, some findings and clinical conditions warrant closer attention to the lesion. CT offers a number of morphological criteria that can be applied to differentiate hypodense lesions of the spleen, such as a the appearance of a lesion’s borders, its attenuation, as well as the presence of calcifications or solid components.MethodsThis article reviews the most common splenic pathologies leading to hypodense appearances on CT images and illustrates the key CT imaging findings in the context of the clinical history of the patients.ConclusionThe key imaging findings of hypodense splenic lesions are presented in order to aid interpretation during routine evaluation of abdominal CT images.Teaching Points• Haemangiomas, congenital in origin, represent the most common benign lesions of the spleen.• Lymphoma represents the most common malignant tumour of the, usually secondarily involved, spleen.• Most hypodense splenic lesions on CT represent benign lesions that require no further work-up.• For correct interpretation, hypodense splenic lesions need to be evaluated in the clinical context.

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Section: Littoral Cell Angiomamentioning

confidence: 99%

Computed tomography of the spleen: how to interpret the hypodense lesion

et al. 2012

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“…11 On abdominal CT with or without contrast enhancement, LCA has been reported to cause hypodense lesions. 9,12 Making a radiologic differential diagnosis of multiple splenic lesions involves an extensive list of possibilities, including several primary vascular neoplasms (hemangioma, lymphangioma, hemangiopericytoma, hemangioendothelioma, angiosarcoma, and hamartoma), malignancies, and systemic diseases. Hemangioma is the most common primary splenic tumor.…”

Section: Discussionmentioning

confidence: 99%

Littoral cell angioma of the spleen: Appearance on sonography and CT

Goldfeld

Cohen

Loberant

et al. 2002

J of Clinical Ultrasound

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Littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen with characteristic histomorphologic features. Only a few descriptions of the radiologic appearance of this tumor have been published, and those descriptions are variable. We report a case of LCA in a 37-year-old man with psoriasis and nonspecific symptoms of weakness, pain and fatigue, normocytic anemia, and thrombocytopenia. The results of abdominal sonography and contrast-enhanced CT correlated: the 2 modalities revealed hepatosplenomegaly and multiple round splenic lesions of similar appearance and size (on sonograms, ill-defined echogenic lesions up to 3.2 cm without acoustic enhancement; on CT scans, hypodense, nonenhancing lesions up to 3.5 cm). Because making a differential diagnosis was difficult and our presumptive diagnosis was hemangioma or lymphoma, splenectomy was performed. Postoperative pathologic examinations confirmed a final diagnosis of LCA. The patient's recovery was uneventful. LCA should be considered when making a differential diagnosis of splenic lesions, and sonography may be more helpful than CT in reaching a diagnosis of LCA.

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“…On the CT scan, they usually appear as multiple hypoattenuating masses 10. MRI showed high signal intensity on unenhanced T2-weighted images, and slightly low signal intensity on unenhanced T1-weighted images 11. MRI is the best radiological imaging method to differentiate between a LCA and other angiomatous vascular lesions 6…”

Section: Discussionmentioning

confidence: 99%

Littoral Cell Angioma (LCA) Associated with Liver Cirrhosis

et al. 2005

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A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen. A 60-year-old man, with multiple nodules in imaging study and liver cirrhosis graded as Child-Pugh classification class A, was transferred for splenomegaly. A thrombocytopenia was found on hematological evaluation. Because there was no evidence of hematological and visceral malignancy, a splenectomy was performed for a definitive diagnosis. The histological and immunohistochemical features of the splenic specimens were consistent with a LCA. After the splenectomy, the thrombocytopenia recovered to the normal platelet count. There has been no previous report of a LCA combined with liver cirrhosis. Herein, the first case of a LCA in Korea, diagnosed and treated by a splenectomy, is reported.

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Littoral cell angioma of the spleen: CT and MR imaging appearance

Cited by 29 publications

References 18 publications

Computed tomography of the spleen: how to interpret the hypodense lesion

Computed tomography of the spleen: how to interpret the hypodense lesion

Littoral cell angioma of the spleen: Appearance on sonography and CT

Littoral Cell Angioma (LCA) Associated with Liver Cirrhosis

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