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Cited by 54 publications
(25 citation statements)
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References 59 publications
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“…Lithium has the best data to support its antisuicidal effects when used in therapeutic doses ( Abou-Saleh et al , 2017 ; Baldessarini et al , 2006 ; Toffol et al , 2015 ). However, miniscule but higher concentrations of lithium in the drinking water are associated with lower rates of suicide in the general population compared with locales with lesser amount of lithium.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Lithium has the best data to support its antisuicidal effects when used in therapeutic doses ( Abou-Saleh et al , 2017 ; Baldessarini et al , 2006 ; Toffol et al , 2015 ). However, miniscule but higher concentrations of lithium in the drinking water are associated with lower rates of suicide in the general population compared with locales with lesser amount of lithium.…”
Section: Resultsmentioning
confidence: 99%
“…It also increases longevity in humans and several animal species ( Zarse et al , 2011 ). It also reduces all-cause mortality in patients with bipolar disorder ( Toffol et al , 2015 ). Whether any of these effects are secondary to its effects in lengthening telomeres remains to be demonstrated.…”
Section: Resultsmentioning
confidence: 99%
“…In a recent review with data from RCTs as well as naturalistic cohort studies Lewitzka et al (5) concluded that "compelling evidence provides strong support that lithium has a suicide protective effect over the long-term course in patients with mood disorders." Its anti-suicidal effect in bipolar disorder was further supported in a recent Finnish nationwide registry-based study among bipolar patients hospitalized because of a suicide attempt between 1996 and 2003 (n=826) (6). The authors looked whether medication use was associated with hospitalization due to attempted suicides, deaths from suicide, and overall mortality during follow-up.…”
Section: What Are the Reasons For This Apparent Discrepancy?mentioning
confidence: 98%
“…These effects have been confirmed in a recent metanalysis [ 110 ]. Interestingly, although for the most part of anti-suicidal treatments achieve their objective by treating depressive correlates, lithium has been described as reducing suicidal behaviors independently from mood improvement [ 111 ]. A large body of evidence suggests that the anti-suicidal effects of lithium may rely on its action on multiple levels of the suicidal process.…”
Section: Eradicating the Roots Of Suicide: Neurobiological Bases Omentioning
confidence: 99%