Lithium Carbonate Response in Depression

Lithium response across generations

“…Many others attempted to discover a laboratory marker of lithium response, with similar outcomes. From a wealth of reports, we have included a few illustrations: lithium transport in red blood cells (30), an RBC/plasma lithium ratio (31), urinary lithium excretion (32), platelet monoaminoxidase activity (33), urinary MHPG and other expressions of central amine metabolism (34), serum calcium and magnesium (35, 36), average evoked potentials (37, 38) and HLA antigens (39). As one example of recent studies, an investigation by Kruger et al.…”

Lithium response across generations

“…Many others attempted to discover a laboratory marker of lithium response, with similar outcomes. From a wealth of reports, we have included a few illustrations: lithium transport in red blood cells (30), an RBC/plasma lithium ratio (31), urinary lithium excretion (32), platelet monoaminoxidase activity (33), urinary MHPG and other expressions of central amine metabolism (34), serum calcium and magnesium (35, 36), average evoked potentials (37, 38) and HLA antigens (39). As one example of recent studies, an investigation by Kruger et al.…”

Lithium Treatment and Prophylaxis in Unipolar Depression: A Meta-analysis

“…There are also methodological short-comings in many of these studies; duration of treatment may have been too short (e.g. Goodwin eta!, 1972;Baron et a!, 1975), and the analysis may be based on the outcome of the patients who remained in the trial, even when an appreciable number of patients dropped out (Watanabe et a!, 1975;Khan, 1981). These objections serve to further qualify our uncertainty, but they cannot much increase it.…”

Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

“…In several subsequent studies of depressive patients, lithium responders showed again steeper pretreatment ASF slopes of SEPs and VEPs [22][23][24][25][26] (table 2). Critical examination, however, reveals that the consistency of these results is less apparent: (1) the components which turned out to be related to the clinical lithium response were not the same in all studies; (2) the amplitudes of these components were measured by an area integration technique in some studies [23][24][25], but not in others; (3) recording was performed over sensory specific and unspecific areas, and (4) different light intensities were used.…”

Lithium response across generations

“…Many others attempted to discover a laboratory marker of lithium response, with similar outcomes. From a wealth of reports, we have included a few illustrations: lithium transport in red blood cells (30), an RBC/plasma lithium ratio (31), urinary lithium excretion (32), platelet monoaminoxidase activity (33), urinary MHPG and other expressions of central amine metabolism (34), serum calcium and magnesium (35, 36), average evoked potentials (37, 38) and HLA antigens (39). As one example of recent studies, an investigation by Kruger et al.…”

Lithium Treatment and Prophylaxis in Unipolar Depression: A Meta-analysis

“…There are also methodological short-comings in many of these studies; duration of treatment may have been too short (e.g. Goodwin eta!, 1972;Baron et a!, 1975), and the analysis may be based on the outcome of the patients who remained in the trial, even when an appreciable number of patients dropped out (Watanabe et a!, 1975;Khan, 1981). These objections serve to further qualify our uncertainty, but they cannot much increase it.…”

Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

“…In several subsequent studies of depressive patients, lithium responders showed again steeper pretreatment ASF slopes of SEPs and VEPs [22][23][24][25][26] (table 2). Critical examination, however, reveals that the consistency of these results is less apparent: (1) the components which turned out to be related to the clinical lithium response were not the same in all studies; (2) the amplitudes of these components were measured by an area integration technique in some studies [23][24][25], but not in others; (3) recording was performed over sensory specific and unspecific areas, and (4) different light intensities were used.…”

Lithium response across generations

“…Many others attempted to discover a laboratory marker of lithium response, with similar outcomes. From a wealth of reports, we have included a few illustrations: lithium transport in red blood cells (30), an RBC/plasma lithium ratio (31), urinary lithium excretion (32), platelet monoaminoxidase activity (33), urinary MHPG and other expressions of central amine metabolism (34), serum calcium and magnesium (35, 36), average evoked potentials (37, 38) and HLA antigens (39). As one example of recent studies, an investigation by Kruger et al.…”

Lithium Treatment and Prophylaxis in Unipolar Depression: A Meta-analysis

“…There are also methodological short-comings in many of these studies; duration of treatment may have been too short (e.g. Goodwin eta!, 1972;Baron et a!, 1975), and the analysis may be based on the outcome of the patients who remained in the trial, even when an appreciable number of patients dropped out (Watanabe et a!, 1975;Khan, 1981). These objections serve to further qualify our uncertainty, but they cannot much increase it.…”

Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

“…In several subsequent studies of depressive patients, lithium responders showed again steeper pretreatment ASF slopes of SEPs and VEPs [22][23][24][25][26] (table 2). Critical examination, however, reveals that the consistency of these results is less apparent: (1) the components which turned out to be related to the clinical lithium response were not the same in all studies; (2) the amplitudes of these components were measured by an area integration technique in some studies [23][24][25], but not in others; (3) recording was performed over sensory specific and unspecific areas, and (4) different light intensities were used.…”