Arch Gen Psychiatry
 1974
DOI: 10.1001/archpsyc.1974.01760070061009
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

Lithium Carbonate and Sleep in Affective Disorders

David J. Kupfer1
Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
53
4
2
0

Citation Types

2
10
1
0

Year Published

1974
1974
2025
2025

Publication Types

Select...
49
10

Relationship

1
58

Authors

Journals

citations

Cited by 59 publications

(13 citation statements)
references

References 9 publications

2
10
1
0
Order By: Relevance
“…This activation of the RAAS by lithium resembles the effects of Mg 2+ supplementation we described here. Additionally, lithium leads to similar changes in sleep we observed with Mg 2+ , especially to an increase in SWS [7,31,48]. Our results therefore support the assumption that Mg 2+ may be a useful supplementary therapy for the clinical management of affective disorder.…”
Section: Endocrine Changes As Cause Of Sleep Eeg Changes?supporting
confidence: 86%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This activation of the RAAS by lithium resembles the effects of Mg 2+ supplementation we described here. Additionally, lithium leads to similar changes in sleep we observed with Mg 2+ , especially to an increase in SWS [7,31,48]. Our results therefore support the assumption that Mg 2+ may be a useful supplementary therapy for the clinical management of affective disorder.…”
Section: Endocrine Changes As Cause Of Sleep Eeg Changes?supporting
confidence: 86%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…First, such medication use would be expected to result in key differences in overall sleep parameters rather than changes specific to SI, as observed here. Second, mood stabilizers, including lithium are associated with increased rather than decreased time spent in SWS (Friston et al, 1989; Harding et al, 1985; Harvey, 2008; Kupfer et al, 1974), yet we observed the opposite in the present study. Future studies, among larger, medication-free samples of patients with TRD are nonetheless needed to confirm effects and guide further research.…”
Section: Discussioncontrasting
confidence: 71%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…An earlier investigation in normal subjects found only a slight, non-significant, increase in SWS (Bert et al 1977). Interestingly, the effect of lithium in decreasing REM sleep, which was detected in this study with automatic sleep stage analysis, has been reported in both depressed and normal subjects (Kupfer et al 1974;Billiard 1987). Lithium also increased the amount of WASO.…”
Section: Discussionsupporting
confidence: 59%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo