Arch Gen Psychiatry
 1982
DOI: 10.1001/archpsyc.1982.04290090053011
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Lithium Carbonate and Imipramine in the Prophylaxis of Unipolar and Bipolar II Illness

John M. Kane1
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Cited by 209 publications

(150 citation statements)
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“…The dosing in the present study may, to some extent, reflect selection of patients who were compliant with long-term lithium maintenance and exclusion of potential poorprognosis patients with comorbid substance abuse or with schizoaffective disorders, who appear in other studies. Nevertheless, the lithium levels we used are consistent with contemporary international practice and with research findings on prospectively determined relationships between lithium blood level and response in bipolar disorders (16,21,44). A provocative possibility is that there may be a trade-off between marginally increased morbid risks associated with flexible and moderate dosing with lithium versus longterm gains due to increased adherence to recommended maintenance treatment.…”
Section: Discussionsupporting
confidence: 68%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The dosing in the present study may, to some extent, reflect selection of patients who were compliant with long-term lithium maintenance and exclusion of potential poorprognosis patients with comorbid substance abuse or with schizoaffective disorders, who appear in other studies. Nevertheless, the lithium levels we used are consistent with contemporary international practice and with research findings on prospectively determined relationships between lithium blood level and response in bipolar disorders (16,21,44). A provocative possibility is that there may be a trade-off between marginally increased morbid risks associated with flexible and moderate dosing with lithium versus longterm gains due to increased adherence to recommended maintenance treatment.…”
Section: Discussionsupporting
confidence: 68%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Patients who received lithium showed significant improvement over the course of the study. Although there are no published randomized acute or maintenance treatment trials of BDII only using Li, these findings support early acute and maintenance findings for a role for Li in the treatment of bipolar depression (Kane et al, 1982;Zornberg and Pope, 1993;Greil and Kleindienst, 1999), suggesting an early acute efficacy maintained into the continuation treatment of bipolar II depression.…”
Section: Discussionsupporting
confidence: 53%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…To our knowledge, only four randomized studies exist that directly assess the longitudinal impact of antidepressant medication exposure on risk for recurrence of bipolar depression in subjects with bipolar disorder concurrently treated with a mood stabilizer (5,(11)(12)(13). While the studies concluded that a mood stabilizer (lithium) in conjunction with an antidepressant (tricyclic) confer no greater protection against depressive relapse than a mood stabilizer alone, these studies are not directly comparable to the present study.…”
Section: Risk Of Depressive Relapsecontrasting
confidence: 60%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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