Listeria Meningitis in Children: Report of Two Cases

Economou, Marina; Karyda, Stavroula; Kansouzidou, A.; Kavaliotis, John

doi:10.1007/s150100050061

Cited by 13 publications

(10 citation statements)

References 9 publications

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“…If gram-positive bacilli are observed in the CSF, meningoencephalitis caused by L. monocytogenes should be suspected; repeat CSF studies and neuroimaging are essential for early detection of neurological complications3, 15).…”

Section: Discussionmentioning

confidence: 99%

A case of meningoencephalitis caused byListeria monocytogenesin a healthy child

et al. 2010

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Listeria monocytogenes is a facultative anaerobic, gram-positive bacillus that is isolated from the soil, vegetables, and wild or domestic animals. Listeria occurs predominantly in the elderly, immunocompromised patients, pregnant women and newborns. Infections by this microorganism are rare in healthy infants and children. L. monocytogenes may cause meningitis, meningoencephalitis, brain abscess, pyogenic arthritis, osteomyelitis, and liver abscesses in children. The course of meningoencephalitis by listeria is often severe and even fatal. Acute hydrocephalus can develop as a complication and the mortality associated with listeriosis is significantly high. We present a case of meningoencephalitis caused by L. monocytogenes in a previously healthy 7-year-old girl.

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Section: Discussionmentioning

confidence: 99%

A case of meningoencephalitis caused byListeria monocytogenesin a healthy child

et al. 2010

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“…Sixty percent of cases have negative Gram stain of the CSF [4,6,7,9] and a large percentage of them also have negative initial cultures of blood and CSF. Bartt [2] has emphasized the utility of the repeat blood and CSF cultures, as they may initially be negative and, thus, confuse the clinician.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of choice in Listeria meningitis has been ampicillin plus a synergistic aminoglycoside, usually gentamicin [4,7,9,10]. When ampicillin is contraindicated, co-trimoxazole is considered, although its use is prohibited in very young infants [7].…”

Section: Discussionmentioning

confidence: 99%

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A case of Listeria meningoencephalitis complicated by hydrocephalus in an immunocompetent infant

et al. 2008

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We report a very unusual case of meningoencephalitis due to Listeria monocytogenes in a 7-month-old immunocompetent boy. Cerebrospinal fluid (CSF) culture was initially negative, but was positive on the seventh day. The disease was complicated by seizures and hydrocephalus managed with temporary ventriculostomy. The infant was discharged without obvious neurological sequelae after 30 days and developed without neurological or developmental sequelae at two years of age. Listeria is difficult to isolate and is not susceptible to third-generation cephalosporins commonly used for the empirical treatment of bacterial meningitis.

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“…Listeria monocytogenes is an intracellular pathogen which causes various diseases such as fulminant Listeriosis, meningitis, endocarditis and disseminated bacteremia mainly in immune-deficient patients and neonates (2,7,8). Listeriolysin secreted by L. monocytogenes, inhibits the procedure of macrophage-mediated processing of bacterial antigens (9,10).…”

Section: Introductionmentioning

confidence: 99%

Effect of Leptin on Neutrophils Phagocytosis and Lymphocytes Apoptosis Challenge by Listeria monocytogenes and Escherichia coli

Morshedi

Zarkesh-Esfahani

Behjati

2013

Jundishapur J Microbiol

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Background: Leptin is a cytokine/hormone produced mainly by the adipocytes which regulates the body weight. The normal level of Leptin is required for optimal immune system function, and high leptin levels are shown to affect the Th1-Th2 balance. Leptin is able to stimulate monocytes, dendritic cells and Neutrophils. Objectives: The aim of this study was to evaluate the effect of leptin on neutrophils phagocytosis and lymphocytes apoptosis stimulated by Listeria monocytogenes and Escherichia coli. Materials and methods: Blood samples were taken from healthy volunteers and were treated with either leptin or PBS in presence or absence of L. monocytogenes or E. coli. In order to evaluate the activation of neutrophils and their phagocytosis activity, the expression of CD11b by these cells were assessed using flow cytometry. The ability of leptin to induce apoptosis in lymphocytes was investigated using Annexin V and PI staining method by flow cytometry. Results: Our data demonstrates that leptin is able to induce CD11b expression on neutrophils but this induction is significantly less than L. monocytogenes. Indeed, cells treated with leptin had lower amounts of apoptosis compared with untreated cells. The highest amount of apoptosis was seen in cells treated with L. monocytogenes vs. E. coli. Leptin can be used as a potent agent for induction of effective bacterial phagocytosis and lymphocytic apoptosis in cases with sever immune-deficiency. Conclusions:The Leptin can also be used for the treatment of severe and intractable L. monocytogenes and E. coli infection.

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Listeria Meningitis in Children: Report of Two Cases

Cited by 13 publications

References 9 publications

A case of meningoencephalitis caused byListeria monocytogenesin a healthy child

A case of meningoencephalitis caused byListeria monocytogenesin a healthy child

A case of Listeria meningoencephalitis complicated by hydrocephalus in an immunocompetent infant

Effect of Leptin on Neutrophils Phagocytosis and Lymphocytes Apoptosis Challenge by Listeria monocytogenes and Escherichia coli

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