This paper applies the theory of rate-independent systems to model the locomotion of bio-mimetic soft crawlers. We prove the well-posedness of the approach and illustrate how the various strategies adopted by crawlers to achieve locomotion, such as friction anisotropy, complex shape changes and control on the friction coefficients, can be effectively described in terms of stasis domains.Compared to other rate-independent systems, locomotion models do not present any Dirichlet boundary condition, so that all rigid translations are admissible displacements, resulting in a non-coercivity of the energy term. We prove that existence and uniqueness of solution are guaranteed under suitable assumptions on the dissipation potential. Such results are then extended to the case of time-dependent dissipation.arXiv:1710.08340v2 [math.FA] 30 Dec 2017 p. gidoni: Rate-independent soft crawlers Physically, this equation is a force balance: configurational forces (e.g. tension in an elastic body) are described as the spatial gradient of the internal energy E, while frictional forces are obtained as the subdifferential of a dissipation potential R, assumed to be positively homogeneous of degree one, in order to guarantee rate-independence.The variational structure of the problem has favoured the development of an advanced and extensive mathematical theory of rate-independent systems, assisting and inspired by applications in physics of solids and continuum mechanics, modelling phenomena such as elastoplasticity, fracture, damage, phase transitions.Along with these, systems with dry friction has immediately emerged as one of the most fitting applications of the theory, already from the first major achievements in the 70s, with the introduction of Moreau's Sweeping processes [49]. As today, dry friction still contributes to the development of the theory. We mention the recent results adopting multiscale approaches to study the effective friction in the case of fast-oscillating bodies [32] and of hairy surfaces [28]; or the illustration of the properties of non-convex rate independent systems using using simple, representative dry friction toy models [2].