1998
DOI: 10.1093/jaoac/81.4.691
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Abstract: Herbal preparations derived from the dried seeds of guarana (Paullinia cupana) have become a popular nutritional supplement used for stimulatory purposes. Once considered a drug substance in the United States, guaraná currently is classified as a food additive and dietary supplement. The pharmacological activity of guaraná-containing products is primarily due to methylxanthine alkaloids. For guaraná preparations, methylxanthine levels and, more significantly, the presence of several polyphenol compounds (i.e.,… Show more

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Cited by 44 publications
(16 citation statements)
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“…This difference may be related to the spectrophotometric method utilized by the supplier, which is not specific for caffeine determination but usually applied to quantify total methylxanthines. However, the amounts we report in the present study are consistent with those found by Carlson and Thompson () and Sousa et al () describing a range of caffeine content of 24–45 mg/g in commercial guarana powders. Since caffeine is a major compound in guarana powder with described therapeutic effects in the context of Alzheimer's disease, it was then used as a positive control for the experiments (Arendash and Cao, ; Prasanthi et al ., ).…”
Section: Discussionsupporting
confidence: 93%
“…This difference may be related to the spectrophotometric method utilized by the supplier, which is not specific for caffeine determination but usually applied to quantify total methylxanthines. However, the amounts we report in the present study are consistent with those found by Carlson and Thompson () and Sousa et al () describing a range of caffeine content of 24–45 mg/g in commercial guarana powders. Since caffeine is a major compound in guarana powder with described therapeutic effects in the context of Alzheimer's disease, it was then used as a positive control for the experiments (Arendash and Cao, ; Prasanthi et al ., ).…”
Section: Discussionsupporting
confidence: 93%
“…It is possible that constituents other than methylxanthines might contribute to the observed antidepressant-like activity of guarana. The presence of flavonoids has been identified in guarana and flavonoids are known to exert an anti-stress/adaptogenic activity (Carlson and Thompson, 1998). Thus the diminution in immobility time observed in mice following guarana extract treatment suggests its possible anti-stress activity but further confirmation, however, is necessary in this regard using other experimental models of stress.…”
Section: Resultsmentioning
confidence: 99%
“…Guarana obtained from the dried seeds of the Amazonian plant Paullinia cupana (Sapindaceae) has a wide reputation as a stimulant beverage or nutritional supplement in conditions such as physical and intellectual stress (Galduróz and Carlini, 1994). Guarana is rich in caffeine (1,3,7trimethylxanthine) and also contains flavonoids [(+)catechin and (−)-epicatechin] and tannins, substances that have proven stimulant, antistress/adaptogenic and antidiarrhoeic properties (Brekhman, 1980;Carlson and Thompson, 1998). The pharmacological activity of guarana-containing products is primarily attributed to the methylxanthine content (Carlson and Thompson, 1998).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Guarana obtained from the dried seeds of Amazonian liana Paullinia cupana (Sapindaceae) has a wide reputation as a stimulant beverage or nutritional supplement in conditions such as physical and intellectual stress (Henman, 1982;Erikson et al, 1984;Galduróz and Carlini, 1994). The seed powder is rich in caffeine (1,3,7trimethylxanthine) and besides it contains flavonoids [(+)-catechin and (−)-epicatechin], and tannins, substances that have proven stimulant, antistress/adaptogenic and antidiarrheic properties (Brekhman, 1980); Loeb et al, 1989;Benowitz, 1990;Rice-Evans et al, 1996;Carlson and Thompson, 1998). Caffeine has been shown to improve some aspects of cognitive and psychomotor performance and mood (Quinlan et al, 1997).…”
Section: Introductionmentioning
confidence: 99%