Liquid chromatographic determination of acids and anions using liquid membrane ion-selective electrodes in a potentiometric flow-through detector

Backer, B. L. De; Nagels, L.J.; Alderweireldt, F. C.; Bogaert, P.P. Van

doi:10.1016/0003-2670(93)80190-v

Cited by 28 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, as shown in Figure 4 tures [55]. In such solutions the effect of preferential solvation of analytes by acetonitrile [56] leads to an increase in basicity of amine compounds [5"7] -increasing the diffusion rates of lipophilic cationic analyres in liquid polymeric membranes [39,58] and enhancing the free energy of supramolecular interactions between amine analytes and neutral macrocyclic ionophores [41,53]. This effect of increasing acetonitrile concentration (up to 60%, v/v) on the observed performance of potentiometric detection in standard-bore cyano RP-LC system was not compensated by reduced dimensions of narrow-bore column used in the second RP-LC system employed in this study.…”

Section: Performance Of Potentiometric Detectionmentioning

confidence: 99%

“…Compared to amperometric detectors, potentiometric detection is not restricted to electroactive compounds. Also it does not need ion suppressor systems as is the case for conductometric detection [39]. Moreover, in contrast to amperometric detectors [35], the response of potentiometric detectors is quasi-independent of flow-rate which creates possibilities for use in miniaturized systems [35] as well as in turbulent flow or ultra-high, flow-rate HPLC systems which are currently recommended as effectively decreasing sample-analysis cycle time [40].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Macrocycleversus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes

2003

View full text Add to dashboard Cite

SummaryPotentiometrTc detection of lipophTlic drugs such as clenbuterol, ambroxol and bromhexine in standard bore cyano and narrow bore hybrid, reversed phase HPLC systems was developed to enable specific determination of these mucolytic agents in some marketed oral formula tions. The macrocycle and podant type, neutral ionophores, respectively: hexaks(2,3,64ri O octyl) ~ cyclodextrin (CDX) and N,N,N',N'4etracyclohexyl oxybis(o phenyleneoxy)diaceta mide flOPA), were used to construct PVC based, liquid membrane electrodes. In addic aqu eous-acetonTtrile, mobTle phases both Tonophores Tmproved the sensitTvTty of these electrodes for mucolytic agents when compared to single-wavelength UV detedTon -as well as wTth the ionophore-free based electrode. In the case of bromhexTne, TndTcating highest ITpophilTdty (IogP6.40), detection limits of 2.6 x ]0 lo and 1.4 x ]0 l~ (injected concentration) were achieved with a signal-to-noTse (S/N) ratio of 3 wTth the TOPA-modified, liquid membrane electrode in the varTous RP-HPLC systems. The results of procedures validated for sTmultaneous potentiometrTc determination of clenbuterol and ambroxol Tn tablets marketed in di[ferent countries are also presented.

show abstract

Section: Performance Of Potentiometric Detectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Macrocycleversus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes

2003

View full text Add to dashboard Cite

show abstract

“…46 ' 47 The iodide ions that are farther from the electrode in the solution need more energy before they will give up an electron. 25 Nevertheless, this method could then be used successfully to determine iodide in aqueous media, because it is possible to oxidize iodide selectively within the limits of the detector.…”

Section: Section Iii: Resultsmentioning

confidence: 99%

“…ii [19][20] capillary electrophoresis (CE), [21][22][23][24][25][26][27] ion selective electrode (ISE),"' 2 and ion chromatography (IC). 2 9 " 34 Gravimetry and liquid-liquid extraction are considered unreliable due to potential anion interference.…”

Section: This Page Intentionally Left Blankmentioning

confidence: 99%

Feasibility Study for the Reduction of Perchlorate, Iodide, and Other Aqueous Anions

Clewell¹,

Tsui²,

Mattie³

1999

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503. Approved for public release; distribution is unlimited. AGENCY USE ABSTRACT (Maximum 200 words)Cyclic Voltammetry (CV) was used as a technique to determine the feasibility of the use of a coulometric detector in the determination of perchlorate, iodide, and various other anions commonly found in drinking water. Through the CV analysis, it was determined that only iodide could" be accurately determined through electrochemical detection. Nitrite, sulfide, and thiocyanate would be reduced, but are poor candidates for coulometric detection. Perchlorate was not reduced within the range of potentials allowed by a coulometric detector. Therefore, it does not appear the coulometry can provide an effective method for the detection of perchlorate. Studies showed that, of the anions tested, only nitrate, sulfide, and thiocyanate would interfere with the detection of iodide.14. However, there are some substances normally found in drinking water that may interfere with perchlorate analysis by ion chromatography, and questions have been raised as to the sensitivity and the robustness of the IC methods. For example, it has been demonstrated in our laboratory that high amounts of total dissolved solid in water samples can block out the response to perchlorate in conductivity measurements.35 Hence, a more sensitive and selective method for the determination of the perchlorate ion is therefore needed.Electrochemical detection has been suggested as an alternative technique to IC, which uses a conductivity detector, due to it's increased sensitivity and ability to selectively detect anions that cannot be separated through chromatography. 35 This technique, which involves the reduction of perchlorate, would not only be useful in the determination of perchlorate, but would also be invaluable in the development of a process for the removal of perchlorate contamination.An inexpensive method for reducing perchlorate to chlorine would dramatically simplify remediation processes. Standard reduction tables indicate that the reduction of perchlorate is thermodynamically favorable. 36Electrochemical detectors apply a potential between a working and reference electrode.This applied potential causes an exchange of electrons to take place in electroactive species at the site of the working electrode. The current that results from the movement of electrons ...

show abstract

“…Also, a range of PVC-based membrane sensors with low selectivity for any particular ion has been used to sense a large number of cations and anions in IC. [11][12][13][14][15][16][17] The copper metal potentiometric chemical sensor has been a particularly successful non-selective sensor for use in IC. [18][19][20][21] Another approach is to use a single sensor membrane which contains several ionophores selective to the ions to be sensed.…”

mentioning

confidence: 99%

The application of a chemical sensor array detector in ion chromatography for the determination of Na+, NH4+, K+, Mg2+ and Ca2+ in water samples

Shen¹,

Cardwell²,

Cattrall³

1998

Analyst

View full text Add to dashboard Cite

Liquid chromatographic determination of acids and anions using liquid membrane ion-selective electrodes in a potentiometric flow-through detector

Cited by 28 publications

References 13 publications

Macrocycleversus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes

Macrocycleversus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes

Feasibility Study for the Reduction of Perchlorate, Iodide, and Other Aqueous Anions

The application of a chemical sensor array detector in ion chromatography for the determination of Na+, NH4+, K+, Mg2+ and Ca2+ in water samples

Contact Info

Product

Resources

About