Infection and Immunity volume 58, issue 6, P1932-1936 1990 DOI: 10.1128/iai.58.6.1932-1936.1990 View Full Text
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S Jackson, J Mestecky, N K Childers, S M Michalek

Abstract: By using a gnotobiotic rat model system to study the induction of protective immune responses by anti-idiotype (anti-id) vaccines specific for antibodies directed at the cariogenic microorganism Streptococcus mutans, it was shown that administration of such an anti-id vaccine provided partial protection against dental caries after challenge with virulent microorganisms. Protective effects were first demonstrated by direct parenteral administration of the anti-id vaccine into salivary gland regions, as determin…

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