2005
DOI: 10.1007/s00280-005-0161-x View full text |Buy / Rent full text
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Abstract: Overall, the ePC/DSPE-PEG liposomes were demonstrated to be a suitable delivery system for ML220. These studies also highlight the potential of cholesterol-free liposomes as a formulation strategy for highly lipophilic drugs.

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“…Imidazoles are an important class of heterocyclic compounds due to their multiple therapeutic and pharmacological actions, such as anti-inflammatory,[34] antimicrobial,[56] anticonvulsant[78] and anticancer[9] activities. Many drugs have imidazole nucleus in their structure [Figure 1], like dacarbazine as anticancer, metronidazole as antifungal, cimetidine as antihistaminics and flumazenil as benzodiazepine antagonist.…”
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“…Imidazoles are an important class of heterocyclic compounds due to their multiple therapeutic and pharmacological actions, such as anti-inflammatory,[34] antimicrobial,[56] anticonvulsant[78] and anticancer[9] activities. Many drugs have imidazole nucleus in their structure [Figure 1], like dacarbazine as anticancer, metronidazole as antifungal, cimetidine as antihistaminics and flumazenil as benzodiazepine antagonist.…”
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“…While a similar, high D/L, mole ratio for other lipophilic drugs such as paclitaxel (0.15), 17 aryl-imidazole compound (ML220) (0.29), 18 and curcumin (0.07) 19 have been reported, the D/L mole ratio for other hydrophobic drugs such as ibuprofen (0.02) 20 and cisplatin (0.05) were low. 21 We previously achieved a maximum D/L mole ratio of 0.104 using DPPC liposomes, synthesized from a saturated lipid that maintained an IOP lowering effect for 50 days in the rabbit eyes.…”
Section: Discussionmentioning
“…[22][23][24] In contrast, notable disintegration of the carrier is usually observed for hydrophobic drug-loaded liposomes, hence limiting its potential for a sustained drug delivery. 18,25,26 Such instability in size greatly limits the use of liposomal carriers for ocular drug delivery. In our study, the latanoprost-loaded liposome formulation had minimal size changes detected at both 4°C (.6 months) and 25°C (.1 month), suggesting that latanoprost does not destabilize the bilayer of EggPC liposomes, and may even help to improve the stability under storage conditions, similar to the effects of cholesterol.…”
Section: Discussionmentioning
“…Liposomes are spherical vesicular nanostructures that are self-assembled from amphiphilic phospholipids. [111][112][113][114] Liposomes have demonstrated the most clinical success, with several FDA-approved formulations for cancer treatment. These clinical successes make liposomes a very attractive platform for multifunctional probes for biomedical applications and a few reports have described the use of liposomes to carry various agents for dualmodality MR/optical imaging.…”
Section: Mri and Optical Imaging Combinationsmentioning