Liposomally entrapped adenosine triphosphate

Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells

“…Liposomes have been extensively studied for loading ATP and have demonstrated increased energetics in ischemic liver, cardiac and brain tissues (18)(19)(20)(21)(22)(23)(24)(25). While liposomes are an established delivery platform, the thin film hydration method results only in a modest loading of 5 mol% ATP (18).…”

Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells

“…Liposomes have been extensively studied for loading ATP and have demonstrated increased energetics in ischemic liver, cardiac and brain tissues (18)(19)(20)(21)(22)(23)(24)(25). While liposomes are an established delivery platform, the thin film hydration method results only in a modest loading of 5 mol% ATP (18).…”

Enhanced cell survival of pH-sensitive bioenergetic nucleotide nanoparticles in energy/oxygen-depleted cells and their intranasal delivery for reduced brain infarction

“…Specifically, it was reported that the encapsulated ATP content of nanosized liposomes was approximately 5-35 wt% [6,7,20,21]. Regarding this, it was reported that intracerebroventricular and intracarotidal delivery of ATP-entrapped liposomes reduced ischemic episodes compared to the delivery of free ATP in a brain ischemic rat model constructed by clamping on-off right carotid artery [22][23][24]. However, multiple steps are normally required to load hydrophilic molecules into vesicles.…”

ATP-Containing Immunoliposomes Specific for Cardiac Myosin

“…In a brain ischemia model, it was observed that the use of ATP-loaded liposomes increased the number of ischemic episodes tolerated before brain electrical silence and death [7,8]. In a hypovolemic shock-reperfusion model in rats, the administration of the liposomal ATP provided protective effects to the liver [9].…”

Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells

“…Liposomes have been extensively studied for loading ATP and have demonstrated increased energetics in ischemic liver, cardiac and brain tissues (18)(19)(20)(21)(22)(23)(24)(25). While liposomes are an established delivery platform, the thin film hydration method results only in a modest loading of 5 mol% ATP (18).…”

Enhanced cell survival of pH-sensitive bioenergetic nucleotide nanoparticles in energy/oxygen-depleted cells and their intranasal delivery for reduced brain infarction

“…Specifically, it was reported that the encapsulated ATP content of nanosized liposomes was approximately 5-35 wt% [6,7,20,21]. Regarding this, it was reported that intracerebroventricular and intracarotidal delivery of ATP-entrapped liposomes reduced ischemic episodes compared to the delivery of free ATP in a brain ischemic rat model constructed by clamping on-off right carotid artery [22][23][24]. However, multiple steps are normally required to load hydrophilic molecules into vesicles.…”

ATP-Containing Immunoliposomes Specific for Cardiac Myosin

“…In a brain ischemia model, it was observed that the use of ATP-loaded liposomes increased the number of ischemic episodes tolerated before brain electrical silence and death [7,8]. In a hypovolemic shock-reperfusion model in rats, the administration of the liposomal ATP provided protective effects to the liver [9].…”

Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells

“…Liposomes have been extensively studied for loading ATP and have demonstrated increased energetics in ischemic liver, cardiac and brain tissues (18)(19)(20)(21)(22)(23)(24)(25). While liposomes are an established delivery platform, the thin film hydration method results only in a modest loading of 5 mol% ATP (18).…”

Enhanced cell survival of pH-sensitive bioenergetic nucleotide nanoparticles in energy/oxygen-depleted cells and their intranasal delivery for reduced brain infarction

“…Specifically, it was reported that the encapsulated ATP content of nanosized liposomes was approximately 5-35 wt% [6,7,20,21]. Regarding this, it was reported that intracerebroventricular and intracarotidal delivery of ATP-entrapped liposomes reduced ischemic episodes compared to the delivery of free ATP in a brain ischemic rat model constructed by clamping on-off right carotid artery [22][23][24]. However, multiple steps are normally required to load hydrophilic molecules into vesicles.…”

ATP-Containing Immunoliposomes Specific for Cardiac Myosin

“…In a brain ischemia model, it was observed that the use of ATP-loaded liposomes increased the number of ischemic episodes tolerated before brain electrical silence and death [7,8]. In a hypovolemic shock-reperfusion model in rats, the administration of the liposomal ATP provided protective effects to the liver [9].…”