Lipoprotein lipase (LPL) mass in preheparin serum reflects insulin sensitivity

High-Sensitivity CRP Reflects Insulin Resistance in Smokers

“…Furthermore, they stimulate a response from the hypothalamic-pituitary-adrenal axis 24) . Consequently, visceral fat obesity results in insulin resistance 12,13,25) , and adipose tissue can therefore cause both mild chronic inflammation and insulin resistance through the actions of cytokines. In healthy subjects in the present study, other mechanisms may be more important than visceral fat obesity in elevating the hs-CRP level because obese subjects (BMI 25) comprised only 11.1% of nonsmokers and 22.4% of smokers 26) .…”

Mechanisms by which diabetes increases cardiovascular disease

“…LPL mass and activity in post heparin plasma not only correlate inversely with triglycerides and non-enzymatically glycated haemoglobin (HbA1c) in type 2 diabetics, but also with insulin resistance [67] and future coronary artery disease even after adjustment for traditional risk factors like blood pressure, LDL serum levels, diabetes or body mass index [68]. LPL seems to be an excellent marker integrating type 2 diabetes and atherogenesis, but there are currently no studies testing for LPL inhibition in order to prevent cardiovascular disease.…”

Serum lipoprotein lipase mass: Clinical significance of its measurement

“…The recent report by Hanyu et al [35] has indicated that serum LPL mass correlated significantly with insulin sensitivity analyzed by minimal model, which is applied to all of the subjects they studied regardless of whether the subjects had normal glucose tolerance, impaired glucose tolerance, and diabetes. Also, serum LPL mass correlated negatively with HOMA-R and fasting IRI.…”