Lipoprotein (a) in patients with aortic aneurysmal disease

Abstract

The lipoprotein (a) serum level, an indicator of atherosclerosis, is significantly elevated in patients with abdominal aneurysms independently of cardiovascular risk factors and the extent of atherosclerosis. Patients with TAAs caused by dissection have lipoprotein (a) levels comparable with healthy individuals.

Increased levels of lipoprotein(a) in non-smoking aortic dissection patients

“…Our findings were not in agreement with one previous study, in which it was reported that patients with TAAs (n = 39) caused by AD have Lp(a) levels comparable to healthy individuals [4]. The inconsistent results might be due to the different criteria for inclusion.…”

“…However, to the best of our knowledge, until now, limited data are available on the association of Lp(a) and AD [4]. The aim of this study was to investigate Lp(a) serum levels in patients with AD and in healthy individuals.…”

“…The concentrations of Lp(a) in human plasma vary from 0 to >300 nmol/l, showing ethnic differences, and appear to be principally under genetic regulation, largely by a well characterized size polymorphism in the apo(a) gene [2]. Increased plasma Lp(a) has been shown to be an independent risk factor for many forms of vascular disease, including peripheral vascular disease (PVD), ischaemic stroke, coronary artery disease (CAD) and abdominal aortic aneurysm (AAA) [3,4].…”

Thoracic Aortic Aneurysm Frequency and Dissection Are Associated With Fibrillin-1 Fragment Concentrations in Circulation

“…First, we think that it provides the first evidence that a biomarker of ECM degradation is associated with aortic aneurysm location. We could find no previous work on ECM biomarkers showing differences between patients with TAA and AAA, although others have compared lipoprotein-a concentration 23 and concomitant medical conditions 24 between these patient groups. Second, the study sample was derived from an aortic aneurysm registry with standardized procedures for blood and data collection.…”

Lipoprotein (a) and Stroke: An Overview~!2009-10-29~!2009-12-27~!2010-04-08~!

“…There are few evidences that there may be an association [55,56]. However, more studies are needed in order to define this role.…”