Lipogenesis in the Ruminant: Effect of Fasting and Refeeding on Fatty Acid Synthesis and Enzymatic Activity of Sheep Adipose Tissue

Ingle, D. L.; Bauman, D. E.; Mellenberger, R. W.; Johnson, Donald E.

doi:10.1093/jn/103.10.1479

Cited by 80 publications

(56 citation statements)

References 31 publications

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“…The increase in the LPL activity is consistent with previous results from Chilliard et al [3] and DiMarco et al [8], who observed that refeeding 2-day-fasted goats for 7 days or 9-day-underfed steers for [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] days increased the LPL activity by a factor of 12 (goats) and 3-7 (steers). The increase in FAS activity with refeeding is higher than the slight increase (+ 4 %) observed in the subcutaneous AT after refeeding 8-dayfasted lambs [18], but this is logical because their refeeding was only at 80 % MER, whereas our refeeding was approximately at 220 % MER. The same pattern of response for FAS activity (+ 84 %) was observed by Smith et al [41] in subcutaneous AT of 4-day-fasted steers refed for 8 days.…”

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confidence: 58%

“…The activities of NADPH-generating enzymes (G6PDH and ME) and the glycerol-3-P-providing enzyme (G3PDH) were 2-to 4-fold higher in the AT of refed as compared to underfed ewes and cows. Smaller but significant variations were observed for G6PDH [18,32] and ME [18] activities in the AT of underfed-refed lambs and steers. There is no information in the literature about the variation in the G3PDH activity in ruminant AT as a function of refeeding.…”

mentioning

confidence: 82%

“…Les [3,8,18,41]. In contrast, underfeeding and refeeding have a stimulatory and an inhibitory effect, respectively, on lipolytic enzymes [43].…”

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confidence: 99%

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Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Bonnet¹,

Faulconnier²,

Fléchet³

et al. 1998

Reprod. Nutr. Dev.

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-The mechanisms involved in the nutritional regulation of genes encoding lipogenic (lipoprotein lipase (LPL) and fatty acid synthase (FAS)) and lipolytic (hormone-sensitive lipase (HSL)) enzymes were investigated by comparing the levels of the corresponding mRNAs in the adipose tissue (AT) of underfed or underfed-refed ewes and cows. Refeeding sharply increased LPL and FAS activities (19-25-and 6-8-fold, respectively) and moderately increased (2-4 fold) the activities of glucose-6-phosphate dehydrogenase (G6PDH), malic enzyme (ME) and glycerol-3-phosphate dehydrogenase (G3PDH

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confidence: 58%

mentioning

confidence: 82%

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Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Bonnet¹,

Faulconnier²,

Fléchet³

et al. 1998

Reprod. Nutr. Dev.

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“…En revanche, dans le tissu adipeux, l'adaptation du métabolisme lipidique en relation avec la croissance et le développement des fonctions digestives du rumen n'a été que partiellement abordée chez les jeunes ruminants (Howarth, Baldwin et Ronning, 1968 ; MorandFehr, 1985 . Une , soit après un sevrage brutal (Ingle et al, 1973). Mais les conditions opéra-toires généralement employées (inhibition par les ions chlorure du milieu) rédui-sent l'activité de l'ACX (Allred et Roehrig, 1980 ;Bas, Houlier et Rouzeau, résul-tats non publiés).…”

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Lipogenèse des tissus adipeux de chevreaux sevrés à 4, 6 et 8 semaines

Bas¹,

Rouzeau²,

Morand-Fehr³

1986

Reprod. Nutr. Dévelop.

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Summary. Lipogenesis in adipose tissues of kids weaned at 4, 6 and 8 weeks.Adipose deposits and their lipogenic enzymes were studied on 27 young Alpine male kids. They were weaned either at 28, 42 or 56 days of age and for each age at weaning, 3 animals were slaughtered unweaned (P 0), or 14 ( P + 14) or 56 (P + 56) days after weaning. They received milk replacer ad libitum from day 5 after birth to weaning and concentrate, hay and water from a week before weaning to slaughter.The adipose tissues were very developed in the abdomen in P 0 and P + 56 animals. Subcutaneous tissues were scarce. All adipose tissues in the P + 14 were lighter. The older the animals, the greater was the reduction in adipose tissue weight between P 0 and P + 14. But this loss was proportionally higher in younger animals. In all P + 14 animals the perirenal tissues showed higher loss.Lipoprotein lipase (LPL) activity was high in abdominal adipose tissues of P 0 and P + 56 kids, particularly in the omental tissue, but was very low in sternal adipose tissue.LPL activity had a low value 14 days after weaning but its specific activity roughly reached the unweaned LPL value 56 days after weaning.By contrast, acetyl CoA carboxylase (ACX) activity was very low in omental adipose tissue but existed even in unweaned kids. Fifty-six days after weaning, this activity was high in 28-day weaned kids. The activity of both glucose-6-phosphate dehydrogenase (G6PDH) and malic enzyme (EM) was high in unweaned kids, particularly at 42 days. Surprisingly, EM activity was higher than G6PDH activity in kids weaned for 56 days. Thus, in ad libitum concentrate-fed kids, the ATP-citrate lyase EM pathway seemed to be active and important for lipogenesis.Introduction.

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“…Parmi les tissus adipeux internes, le tissu périrénal est plus précoce que le tissu omental mais celui-ci croît rapidement et sa masse devient plus importante que celle du tissu périrénal dès l'âge de 30 jours. Des résultats comparables ont été obtenus préalablement sur caprins (Morand-Fehr et Bas, 1984), et sur ovins (Vézinhet et Prud'hon, 1975) (Broad, Davies et Tan, 1980 ;Robelin, 19811, ce (Ingle et al, 1973 ; Beitz, 1973Beitz, , 1975Di Marco, Beitz et Whitehurst, 1981 ; Bas, 1984 …”

unclassified

Poids et métabolisme des réserves lipidiques au cours de la croissance du chevreau

Bas¹,

Rouzeau²,

Morand-Fehr³

1985

Reprod. Nutr. Dévelop.

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Lipogenesis in the Ruminant: Effect of Fasting and Refeeding on Fatty Acid Synthesis and Enzymatic Activity of Sheep Adipose Tissue

Cited by 80 publications

References 31 publications

Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Lipogenèse des tissus adipeux de chevreaux sevrés à 4, 6 et 8 semaines

Poids et métabolisme des réserves lipidiques au cours de la croissance du chevreau

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