Lipodystrophia centrifugalis abdominalis infantilis with Ulceration

Aoki, Eiichiro; Kawana, Satoshi

doi:10.1159/000018377

Cited by 9 publications

(13 citation statements)

References 3 publications

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“…Ulceration is a rare skin manifestation of LCA. Our review of the literature found only three previous LCA cases associated with ulceration 6–8 . The Japanese girl reported by Aoki and Kawana 6 first manifested LCA at the age of 6 months.…”

Section: Discussionmentioning

confidence: 85%

Lipodystrophia centrifugalis abdominalis infantilis manifesting as recurrent skin ulcerations

2009

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Section: Discussionmentioning

confidence: 85%

Lipodystrophia centrifugalis abdominalis infantilis manifesting as recurrent skin ulcerations

2009

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“…About two‐thirds of patients have palpable ipsilateral lymphadenopathy 7 . A report of associated ulceration has been published 10 …”

Section: Discussionmentioning

confidence: 99%

“…7 A report of associated ulceration has been published. 10 Histopathology varies by area of involvement. Biopsy from the central depressed area of the lesion shows a decreased amount or complete loss of subcutaneous fat.…”

Section: Discussionmentioning

confidence: 99%

Lipodystrophia centrifugalis abdominalis infantilis in a Caucasian girl: report of a case with perieccrine inflammation

2008

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Lipodystrophia centrifugalis abdominalis infantilis (LCAI) is a rare, self-limiting disease typically affecting Asian children around the age of three. In classic cases, patients present with a hypopigmented patch with central atrophy and an erythematous border in the groin area. We present a case of LCAI affecting a female Caucasian toddler that shows striking perieccrine inflammation, a finding not previously reported in this entity. LCAI has been rarely reported in Caucasian children; as a result, there is sparse literature on the histopathological findings in this subset. This case illustrates how significant deep dermal and perieccrine inflammation can be seen in this condition, thus broadening the histopathological spectrum of this disorder.

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“…Treatment of LCA is ineffective (5–18). In previous studies, oral penicillamine, systemic prednisolone, topical corticosteroids, and topical dimethyl sulfoxide were used without benefit (5–18). In one of our patients, photochemotherapy resulted in softening and cessation of the enlargement without notable histologic change.…”

Section: Discussionmentioning

confidence: 99%

Lipodystrophia Centrifugalis Abdominalis in Korea

Chang

Bae

Jeong

et al. 2004

Pediatric Dermatology

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Lipodystrophia centrifugalis abdominalis infantilis is a rare disorder described exclusively in Asians. Thirty Korean patients (4 women, 20 girls, and 6 boys) with a clinical and/or histopathologic diagnosis of this disorder were evaluated. The mean age of onset was 6.2 years. Infantile or congenital onset was seen in only three girls and two boys. In 50% of females, onset was after 5 years of age. All patients had involvement of the lower abdomen and groin both as the site of onset and as the main site. Histopathologic analysis showed loss of fat with or without an infiltrate of lymphocytes and histiocytes in the subcutis. Only one patient responded to treatment, an adult female who received photochemotherapy with softening of the lesions and symptomatic improvement. In previous reports, the age of onset of this disorder was at an age younger than 5 years but older than infants, making the term lipodystrophia centrifugalis abdominalis juvenilis more appropriate. In our series, 50% of females had onset after 5 years of age and 12.5% after 18 years of age. In one woman, the lesion that developed at 4 years of age progressed until adulthood. Our study of affected Korean patients showed a fourfold female predilection and later onset in female patients.

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Lipodystrophia centrifugalis abdominalis infantilis with Ulceration

Cited by 9 publications

References 3 publications

Lipodystrophia centrifugalis abdominalis infantilis manifesting as recurrent skin ulcerations

Lipodystrophia centrifugalis abdominalis infantilis manifesting as recurrent skin ulcerations

Lipodystrophia centrifugalis abdominalis infantilis in a Caucasian girl: report of a case with perieccrine inflammation

Lipodystrophia Centrifugalis Abdominalis in Korea

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