Lipids and Stroke

Abstract

Elevated low-density lipoprotein cholesterol and triglyceride levels are significant independent risk factors in patients with proven atherothrombotic cerebrovascular disease manifesting as stroke or transient ischemic attack. The level of stored serum iron, as reflected by serum ferritin levels, does not correlate with the presence of atherothrombotic cerebrovascular or coronary disease.

Differential Associations of Inflammatory Biomarkers and Clinical Risk Factors with Acute Coronary Syndrome versus Ischemic Stroke: A Comparative Hospital-Based Study in Northwest Iran

“…The inverse association observed between LDL cholesterol and AIS presentation is consistent with the previously described "lipid paradox" in stroke populations and may reflect differences in underlying vascular pathology -lipid-rich atheromatous plaques being more characteristic of coronary disease, whereas ischemic stroke in this study population, which included a substantial proportion of older women, may more often relate to hypertensive small-vessel disease or cardioembolic mechanisms not well captured by serum lipid levels (27)(28)(29). We note, however, that this study's case-case design, which lacks a disease-free comparison group, precludes any inference about whether LDL is a risk factor for either condition in the general population; it can only speak to relative differences between patients already presenting with one of the two conditions.…”

Differential Associations of Inflammatory Biomarkers and Clinical Risk Factors with Acute Coronary Syndrome versus Ischemic Stroke: A Comparative Hospital-Based Study in Northwest Iran

“…The inverse association observed between LDL cholesterol and AIS presentation is consistent with the previously described "lipid paradox" in stroke populations and may reflect differences in underlying vascular pathology -lipid-rich atheromatous plaques being more characteristic of coronary disease, whereas ischemic stroke in this study population, which included a substantial proportion of older women, may more often relate to hypertensive small-vessel disease or cardioembolic mechanisms not well captured by serum lipid levels (27)(28)(29). We note, however, that this study's case-case design, which lacks a disease-free comparison group, precludes any inference about whether LDL is a risk factor for either condition in the general population; it can only speak to relative differences between patients already presenting with one of the two conditions.…”

Risk factors and subtypes of acute ischemic stroke

“…Elevated low-density lipoprotein cholesterol and triglyceride levels are significant risk factors in patients with atherothrombotic cerebrovascular disease presenting as stroke or transient ischemic attack. Hypercholesterolemia is a recognized risk factor for stroke due to LAA 26. No statistically significant difference could be identified in the prevalence of dyslipidemia across IS subtypes in our study.…”

Metabolic syndrome and its components with neuron-specific enolase: a cross-sectional study in large health check-up population in China

“… 31 Similar results were obtained by other workers. 32 33 However, there are some reports indicating no association between NSE and TGs at all. 34 35 Thus, from the viewpoint of previous research, the correlation between TG and stroke or ischaemic stroke was controversial, partly due to differences in blood samples used, some collected the non-fasting blood samples, 30 32 while others used fasting blood samples.…”

Differential Associations of Inflammatory Biomarkers and Clinical Risk Factors with Acute Coronary Syndrome versus Ischemic Stroke: A Comparative Hospital-Based Study in Northwest Iran

“…The inverse association observed between LDL cholesterol and AIS presentation is consistent with the previously described "lipid paradox" in stroke populations and may reflect differences in underlying vascular pathology -lipid-rich atheromatous plaques being more characteristic of coronary disease, whereas ischemic stroke in this study population, which included a substantial proportion of older women, may more often relate to hypertensive small-vessel disease or cardioembolic mechanisms not well captured by serum lipid levels (27)(28)(29). We note, however, that this study's case-case design, which lacks a disease-free comparison group, precludes any inference about whether LDL is a risk factor for either condition in the general population; it can only speak to relative differences between patients already presenting with one of the two conditions.…”

Risk factors and subtypes of acute ischemic stroke

“…Elevated low-density lipoprotein cholesterol and triglyceride levels are significant risk factors in patients with atherothrombotic cerebrovascular disease presenting as stroke or transient ischemic attack. Hypercholesterolemia is a recognized risk factor for stroke due to LAA 26. No statistically significant difference could be identified in the prevalence of dyslipidemia across IS subtypes in our study.…”

Metabolic syndrome and its components with neuron-specific enolase: a cross-sectional study in large health check-up population in China

“… 31 Similar results were obtained by other workers. 32 33 However, there are some reports indicating no association between NSE and TGs at all. 34 35 Thus, from the viewpoint of previous research, the correlation between TG and stroke or ischaemic stroke was controversial, partly due to differences in blood samples used, some collected the non-fasting blood samples, 30 32 while others used fasting blood samples.…”

Differential Associations of Inflammatory Biomarkers and Clinical Risk Factors with Acute Coronary Syndrome versus Ischemic Stroke: A Comparative Hospital-Based Study in Northwest Iran

“…The inverse association observed between LDL cholesterol and AIS presentation is consistent with the previously described "lipid paradox" in stroke populations and may reflect differences in underlying vascular pathology -lipid-rich atheromatous plaques being more characteristic of coronary disease, whereas ischemic stroke in this study population, which included a substantial proportion of older women, may more often relate to hypertensive small-vessel disease or cardioembolic mechanisms not well captured by serum lipid levels (27)(28)(29). We note, however, that this study's case-case design, which lacks a disease-free comparison group, precludes any inference about whether LDL is a risk factor for either condition in the general population; it can only speak to relative differences between patients already presenting with one of the two conditions.…”

Risk factors and subtypes of acute ischemic stroke

“…Elevated low-density lipoprotein cholesterol and triglyceride levels are significant risk factors in patients with atherothrombotic cerebrovascular disease presenting as stroke or transient ischemic attack. Hypercholesterolemia is a recognized risk factor for stroke due to LAA 26. No statistically significant difference could be identified in the prevalence of dyslipidemia across IS subtypes in our study.…”

Metabolic syndrome and its components with neuron-specific enolase: a cross-sectional study in large health check-up population in China

“… 31 Similar results were obtained by other workers. 32 33 However, there are some reports indicating no association between NSE and TGs at all. 34 35 Thus, from the viewpoint of previous research, the correlation between TG and stroke or ischaemic stroke was controversial, partly due to differences in blood samples used, some collected the non-fasting blood samples, 30 32 while others used fasting blood samples.…”