Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development

Long-Term Effects of Vitamin E, Vitamin C, and Combined Supplementation on Urinary 7-Hydro-8-Oxo-2′-Deoxyguanosine, Serum Cholesterol Oxidation Products, and Oxidation Resistance of Lipids in Nondepleted Men

“…In our previous follow-up study, butylated hydroxytoluene serum 7␤OH concentration was a very strong predictor of atherosclerotic progression. 26 Also, Carpenter et al 46 found high concentrations of 7␤OH in early atherosclerotic lesions. Lizard et al 25 and Deckert et al 27 observed that 7␤OH inhibited arterial relaxation and had the greatest ability to induce apoptosis in endothelial cells of all cholesterol oxides measured.…”

Dissociation of atherogenesis from aortic accumulation of lipid hydro(pero)xides in Watanabe heritable hyperlipidemic rabbits

“…Aortic contents of LOOH and LOH were comparable. This contrasts with levels in advanced human plaque (12,14) and lesions in apo E receptor-deficient, LDL receptor-deficient (19), and apo E-deficient mice (15), in all of which LOH predominates. LO(O)H were detected in 9 of 11 aortas from control rabbits, albeit at markedly different concentrations ( Figure 2b and Table 4).…”

“…The presence of oxidized lipids in atherosclerotic lesions is well documented (12), although it remains unclear how lipoprotein-derived lipids become oxidized. Various mechanisms have been suggested (2).…”

Oxysterols are substrates for cholesterol sulfotransferase

“…Of particular interest are the high levels of oxysterols in atheromas because of their association with instability and rupture, a prelude to myocardial infarction (5,6). A major oxysterol found in atheromas as well as other tissues is 7-ketocholesterol (7-KC), which is known from cell culture studies to induce cell injury at concentrations present in vivo (7,8); for this reason, there exists a particular focus on metabolic pathways that can lead to a reduction in its toxicity.…”