Lipids: A key role in multidrug resistance? (Review).

Pallarés-Trujillo, J.; López‐Soriano, Francisco J.; Argilés, Josep M.

doi:10.3892/ijo.16.4.783

Cited by 23 publications

(33 citation statements)

References 73 publications

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“…PLs can play a role in parasite resistance to immune attack by cytotoxic antibodies and complement (Billecocq 1987). PL affects the activities of intramembrane proteins and the solubilization of xenobiotic molecules (Pallares-Trujillo et al 2000;Kremer et al 2001). Corroborating the above inference, it can be said that Raillietina being a cestode possess long body with large surface area which require more PL to survive against immune attack within host body and also for structuring the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

Variation in lipid and fatty acid uptake among nematode and cestode parasites and their host, domestic fowl: host–parasite interaction

Mondal¹,

Kundu

Misra³

2016

J Parasit Dis

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Lipid synthesis is an important process in most organisms as well as in helminths. The present observation shows the variation of lipid and fatty acid uptake among cestode, Raillietina (Fuhrmannetta) echinobothrida; nematode, Ascaridia galli and their host, Gallus domesticus, the common country fowl. Total lipid (TL), neutral lipid (NL), glycolipid (GL), phospholipid (PL) and their fatty acid of cestode, nematode and liver and intestinal fluid of the host were analyzed by thin layer chromatography and gas liquid chromatography respectively. The result shows that liver take more TL, PL and GL except NL. Utilization of lipid from intestinal fluid when compare between the parasites, it is found that TL and PL content of cestode are higher than nematode, whereas, nematode absorbs more NL and GL than cestode. The percent of cholesterol is more in cestode than nematode. Palmitic, stearic, oleic and linoleic are the predominant fatty acids among all the samples. The present study reveals that the cestode having large surface area is more opportunistic in the resource utilization over the nematode as well as the host.

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Section: Discussionmentioning

confidence: 99%

Variation in lipid and fatty acid uptake among nematode and cestode parasites and their host, domestic fowl: host–parasite interaction

Mondal¹,

Kundu

Misra³

2016

J Parasit Dis

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“…Many chemoresistant cell lines show a modification in their plasma membrane lipid content. [15][16][17][18][19][20][21] Cholesterol is one of the lipids known to be abundant in chemoresistant cell membranes. [15][16][17][18][19][20][21] Interestingly, total cholesterol content was greatly increased in both R1 and R2 cell lines as illustrated in Figure 7.…”

Section: Role Of Caveolin-1 In Etoposide Resistance Development In A5mentioning

confidence: 99%

“…[10][11][12][13][14][15] It has recently been shown that p-glycoprotein (P-gp), an ATP-dependent membraneassociated efflux transporter was colocalized with caveolin within caveolae domains, and that P-gp ATPase activity was stimulated in certain lipid domains. [15][16][17][18][19][20][21] Knowing that cholesterol is one of the P-gp-stimulating lipid and it's found abundantly in caveolae, we were interested to study the role if any, of caveolin in the MDR phenotype development. 19,22 In this study, we investigated the level expression of caveolin 1 during drug-resistance development to etoposide (VP-16) of A549 lung cancer cell line.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18][19][20][21] Knowing that cholesterol is one of the P-gp-stimulating lipid and it's found abundantly in caveolae, we were interested to study the role if any, of caveolin in the MDR phenotype development. 19,22 In this study, we investigated the level expression of caveolin 1 during drug-resistance development to etoposide (VP-16) of A549 lung cancer cell line. We now report that the increase of caveolin 1 expression is present during the MDR phenotype development but is not directly related to it.…”

Section: Introductionmentioning

confidence: 99%

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Role of caveolin-1 in etoposide resistance development in A549 lung cancer cells

Bélanger¹,

Gaudreau²,

Roussel³

et al. 2004

Cancer Biology & Therapy

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Caveolin 1 expression is downregulated in various cancer cell lines. Interestingly, in several drug-resistant cancer cells, a strong induction of caveolin 1 expression has been reported suggesting a role for caveolin 1 in the acquisition and/or the maintenance of multidrug resistance phenotype. In addition, it was reported that p-glycoprotein localized to caveolin-rich membrane domains in these cells. In this study, we progressively exposed A549 lung adenocarcinoma cells to increasing doses of etoposide. Both R1 and R2 cell lines had greatly increased levels of p-glycoprotein expression while mrp expression levels were moderately increased but only R2 cells had raised caveolin levels compared to control A549 cells. Both caveolin-1 and p-glycoprotein colocalize in Triton-insoluble membrane domains in all our cell lines but only caveolins-1 was solubilized by the addition of octylglucoside at 4C suggesting that these two proteins are located in different membrane domains. Using an anti-caveolin-1 antibody, we did not succeed to immunoprecipitate p-glycoprotein. Interestingly, total cellular cholesterol (the major lipid component of caveolae and triton-insoluble domains) was greatly increased in both R1 and R2 cell lines compared to naïve A549 cells.

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“…Signaling pathways constitutively active in AML such as PI-3K/Akt/ Rac-1, 32 PLC␥/Raf/Erk, 33,34 and PKC␣ 35,36 each have been implicated in transcriptional activation of MDR1. AML cells that express P-gp display a reproducible survival advantage ex vivo.…”

Section: Mdr1 Expression Promotes Cell Survivalmentioning

confidence: 99%

Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategies

Mahadevan

List

2004

Blood

143

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The multidrug resistance-1 (MDR1) gene product, P-glycoprotein (P-gp), and the multidrug resistance-related proteins (MRPs) are members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter gene superfamily that regulates the trafficking of drugs, peptides, ions, and xenobiotics across cell membrane barriers. Threedimensional modeling of human MDR1/ P-gp indicates that these glycoproteins function as efficient, ATP-dependent gatekeepers, which scan the plasma membrane and its inner leaflet to flip lipophilic substrates to the outer membrane leaflet. Delineation of the adverse prognostic power of MDR1 in adult acute myeloid leukemia (AML) raised hopes that pharmacologic blockade of P-gp would improve the outcome of conventional cytotoxic therapy, perhaps more so than in any other human malignancy. Phase 3 clinical trials investigating first-and second-generation P-gp antagonists have yielded conflicting results, emphasizing the importance of applying preclinical principals to realistically appraise expectations for clinical benefit. Structure-based design strategies and the delineation of transcriptional regulators of survival gene cassettes promise to yield novel, more-effective strategies to overcome drug resistance. Lessons learned from investigations of these and other mechanisms of cellular defense hold promise for a renaissance in the development of targeted therapeutics in acute

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Lipids: A key role in multidrug resistance? (Review).

Cited by 23 publications

References 73 publications

Variation in lipid and fatty acid uptake among nematode and cestode parasites and their host, domestic fowl: host–parasite interaction

Variation in lipid and fatty acid uptake among nematode and cestode parasites and their host, domestic fowl: host–parasite interaction

Role of caveolin-1 in etoposide resistance development in A549 lung cancer cells

Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategies

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