Lipid‐soluble fraction of <i><scp>S</scp>hakuyaku‐kanzo‐to</i> inhibits myometrial contraction in pregnant women

Sumi, Genichiro; Yasuda, Katsuhiko; Tsuji, Shoko; Kanamori, Chiharu; Tsuzuki, Tomoko; Cho, Hisayuu; Nishigaki, Akemi; Okada, Hidetaka; Kanzaki, Hideharu

doi:10.1111/jog.12618

Cited by 3 publications

(3 citation statements)

References 23 publications

(48 reference statements)

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“…The study found that the lipid-soluble fractions, obtained from shakuyaku-kanzo-to and kanzo, inhibited myometrial contraction, while the water-soluble fractions had no effect on contractions. These results suggest that lipid-soluble substances with low polarity derived from kanzo are responsible for the inhibitory effect of shakuyaku-kanzo-to on myometrial contraction 68…”

Section: Partus Preparatorsmentioning

confidence: 78%

“…These results suggest that lipid-soluble substances with low polarity derived from kanzo are responsible for the inhibitory effect of shakuyakukanzo-to on myometrial contraction. 68 Western Herbs for Labor Preparation Blue Cohosh (Caulophyllum thalictroides) Blue Cohosh was labeled in the United States Pharmacopeia in the 19th century for labor induction and is often used in combination with other herbs including black cohosh. 69 Blue cohosh contains n-methylcytisine and anagyrine, both of which have been associated with fetal malformations including cardiovascular and craniofacial anomalies.…”

Section: Tcm and Eastern Herbs For Contraction Inhibition And Painmentioning

confidence: 99%

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Herbalism for Modern Obstetrics

Feigel

Kennard

Lannaman

2021

Clinical Obstetrics &Amp; Gynecology

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More pregnant and nursing mothers are using herbal remedies than health care providers realize. Lack of familiarity with herbalism in addition to the sparsity of high-quality research for many complementary and alternative medicines are barriers for the western practitioner to engage a patient about herbal therapies. This review provides historical information and available evidence for Traditional Chinese and Western herbal medicines commonly sought by pregnant and nursing mothers. We will review herbs commonly used for: nausea and vomiting, constipation, gestational diabetes, threatened miscarriage, immune system support, parturition preparation, postpartum depression, postpartum bleeding and pain, wound healing, and lactation support.

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Section: Partus Preparatorsmentioning

confidence: 78%

Section: Tcm and Eastern Herbs For Contraction Inhibition And Painmentioning

confidence: 99%

Herbalism for Modern Obstetrics

Feigel

Kennard

Lannaman

2021

Clinical Obstetrics &Amp; Gynecology

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“…SKT has been reported to inhibit acetylcholine‐induced and neurogenic contractions of the gastrointestinal tract and to decrease unfavorable smooth muscle contractions during upper and lower gastrointestinal endoscopy . SKT also inhibits oxytocin‐induced myometrial contractions of uterine tissue in pregnant women in a dose‐dependent manner . In addition to ameliorating muscle symptoms, SKT has been found to improve extrapyramidal symptoms while exerting no significant effect on psychiatric symptoms .…”

Section: Discussionmentioning

confidence: 99%

Effect of Shakuyaku‐kanzo‐to in patients with muscle cramps: A systematic literature review

Ota

Fukui

Nakamura

et al. 2020

J of Gen and Family Med

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Background Previous clinical studies have reported that Shakuyaku‐kanzo‐to (SKT) has a therapeutic effect on muscle cramps, but few studies have clarified how SKT acts to treat muscle cramps. The aim of this study was to perform an updated systematic review of clinical trials for SKT in patients with muscle cramps. Methods The literature was systematically reviewed to assess the effects of SKT in patients with muscle cramps. PubMed, Web of Science, Cochrane Library, Google Scholar, and Ichushi‐Web were searched using the terms “Shakuyaku‐kanzo‐to” (“shakuyakukanzoto”, etc), “clinical trials” and “muscle cramps”. Two quality assessments were conducted independently by three authors. Data were extracted using a standardized extraction tool, and a qualitative synthesis of evidence was performed. Results Three randomized controlled articles were identified and enrolled in this study. A systematic review, but not a meta‐analysis, was performed because of the high heterogeneity and limited number of studies. In patients with liver cirrhosis, the odds ratio (OR) for improvement with SKT compared to placebo was 1.27 (95% confidence interval [CI], 0.445‐2.086) and compared to Goshajinkigan was 0.81 (95%CI, −1.734‐0.114). The OR for improvement with SKT compared with eperisone hydrochloride in patients with lumbar spinal stenosis was 2.86 (95%CI, 0.980‐4.744). Conclusions Current evidence appears insufficient to allow a meta‐analysis of the effects of SKT, but SKT might show efficacy in treating muscle cramps in patients with cirrhosis or lumbar spinal stenosis.

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