Lipid signalling in disease

Wymann, Matthias P.; Schneiter, Roger

doi:10.1038/nrm2335

Cited by 1,126 publications

(935 citation statements)

References 148 publications

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“…Among BCR-ABL regulated genes, one gene named Alox5 is noticeable. Alox5 is linked to many important pathways including P53 and PI3K, and is thought to play an important role in different diseases (Catalano et al, 2005;Wymann and Schneiter, 2008). We tested the function of Alox5 in BCR-ABL induced CML mice.…”

Section: An Essential Role Of the Alox5 Gene In Lscsmentioning

confidence: 99%

Molecular and cellular bases of chronic myeloid leukemia

Chen¹,

Peng²,

Li³

et al. 2010

Protein Cell

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Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the overproduction of granulocytes, which leads to high white blood cell counts and splenomegaly in patients. Based on clinical symptoms and laboratory findings, CML is classified into three clinical phases, often starting with a chronic phase, progressing to an accelerated phase and ultimately ending in a terminal phase called blast crisis. Blast crisis phase of CML is clinically similar to an acute leukemia; in particular, B-cell acute lymphoblastic leukemia (B-ALL) is a severe form of acute leukemia in blast crisis, and there is no effective therapy for it yet. CML is induced by the BCR-ABL oncogene, whose gene product is a BCR-ABL tyrosine kinase. Currently, inhibition of BCR-ABL kinase activity by its kinase inhibitor such as imatinib mesylate (Gleevec) is a major therapeutic strategy for CML. However, the inability of BCR-ABL kinase inhibitors to completely kill leukemia stem cells (LSCs) indicates that these kinase inhibitors are unlikely to cure CML. In addition, drug resistance due to the development of BCR-ABL mutations occurs before and during treatment of CML with kinase inhibitors. A critical issue to resolve this problem is to fully understand the biology of LSCs, and to identify key genes that play significant roles in survival and self-renewal of LSCs. In this review, we will focus on LSCs in CML by summarizing and discussing available experimental results, including the original studies from our own laboratory.

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Section: An Essential Role Of the Alox5 Gene In Lscsmentioning

confidence: 99%

Molecular and cellular bases of chronic myeloid leukemia

Chen¹,

Peng²,

Li³

et al. 2010

Protein Cell

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“…Candidate molecules for this are related to FAs and act in signaling cascades that are important for insulin action, inflammation, immunity and oxidative stress. 20 They include FAs, cytoplasmic long-chain FA-CoAs (LCFA-CoAs), ceramides and diacylglycerols (DGs).…”

Section: Other Physiological Changes In Obesitymentioning

confidence: 99%

“…The inhibition of hormonesensitive lipase (HSL) is a cited therapeutic target for obesity and diabetes. 20,[24][25][26] Conversely, ensuring continual longterm lipolytic activity is a much-desired but elusive goal for children who require a ketogenic diet for the treatment of epilepsy or certain hereditary diseases of carbohydrate metabolism. 27 Such children live under constant threat of an abrupt reduction of lipolysis and ketogenesis, which can be caused by inadvertent intake of small amounts of sugar, and which can result in sudden worsening of symptoms.…”

Section: The Significance Of Lipolysismentioning

confidence: 99%

Genetics, physiology and perinatal influences in childhood obesity: view from the Chair

Mitchell

2009

Int J Obes

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The current epidemic of childhood obesity will be a serious threat to population health for at least the next several decades. The biology of childhood obesity was the theme of an international symposium held in November 2007. Speakers discussed monogenic causes of obesity, prenatal epigenetic programing, neurobehavioral aspects of obesity, and hormonal and neuroendocrine abnormalities, and the insights provided by non-murine models for understanding the biology of early-onset obesity. Several new developments have been reported in white and brown adipose tissue biology. They are summarized briefly in this review and include observations about cell lineage of adipocytes, the renewal of adipocytes throughout life and the numerous factors that influence adipocyte fatty acid release. The biological underpinnings of childhood obesity are multiple and complex.

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“…For each antigen, Mann Whitney and receiver operating characteristic-based analysis were performed to evaluate any statistical significance of the results. The five natural triterpene glycosides showed good capacity to recognize IgMs (sensitivity up to 38 %) with a high specificity (88.9%) for multiple sclerosis patients.Key words multiple sclerosis · triterpene glycosides · autoimmune disease · biomarkers · autoantibody recognition Supporting information available online at http://www.thieme-connect.de/products Complex glycoconjugates, including glycolipids and glycoproteins, are commonly displayed on cell surfaces, where they play crucial roles as intermediaries in extracellular communication and signalling networks [1][2][3]. Therefore, studies on glycan modification patterns of glycoconjugates are a great challenge in medical diagnostic research, offering insight into cellular molecular mechanisms.…”

mentioning

confidence: 99%

“…Complex glycoconjugates, including glycolipids and glycoproteins, are commonly displayed on cell surfaces, where they play crucial roles as intermediaries in extracellular communication and signalling networks [1][2][3]. Therefore, studies on glycan modification patterns of glycoconjugates are a great challenge in medical diagnostic research, offering insight into cellular molecular mechanisms.…”

mentioning

confidence: 99%

Natural Triterpene Glycosides for Antibody Recognition

et al. 2016

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!Multiple sclerosis is an autoimmune disease that affects the central nervous system. The key role of the glycosylation in disease pathogenesis has been previously studied and the synthetic Nglucosylated peptide CSF114(Glc) proved its efficiency in autoantibody recognition in the sera of multiple sclerosis patients. Herein, pure natural triterpene glycosides containing different glycosyl moieties were isolated and tested in multiple sclerosis patientsʼ sera to better understand the role of glycosylation. They were selected taking into account the nature and complexity of their osidic part. Five triterpene glycosides were isolated from several plants with more than 95% purity. The interaction between these glycosides and autoantibodies was evaluated in an enzyme-linked immunosorbent assay measuring IgG and IgM levels in multiple sclerosis patients and healthy blood donors, and the results were compared with those of CSF114(Glc). For each antigen, Mann Whitney and receiver operating characteristic-based analysis were performed to evaluate any statistical significance of the results. The five natural triterpene glycosides showed good capacity to recognize IgMs (sensitivity up to 38 %) with a high specificity (88.9%) for multiple sclerosis patients.Key words multiple sclerosis · triterpene glycosides · autoimmune disease · biomarkers · autoantibody recognition Supporting information available online at http://www.thieme-connect.de/products Complex glycoconjugates, including glycolipids and glycoproteins, are commonly displayed on cell surfaces, where they play crucial roles as intermediaries in extracellular communication and signalling networks [1][2][3]. Therefore, studies on glycan modification patterns of glycoconjugates are a great challenge in medical diagnostic research, offering insight into cellular molecular mechanisms. Moreover, glycoconjugates can be proposed as molecular biomarkers for the disease activity [4,5]. In the field of autoimmunity, different approaches are used to investigate the structures and functions of complex naturally occurring glycoconjugates leading to the identification of autoantigens associated with different autoimmune diseases. In particular, in the context of multiple sclerosis (MS), the development of serum antibodies as biomarkers to be used for the diagnosis, monitoring, and prognosis of such a heterogeneous disease is a challenge because of the ambiguous identification of antigens (Ags) implicated in the disease. MS pathogenesis has not been yet elucidated but includes viral, immunological, and vascular hypotheses [6]. Most of the putative Ags belong to the myelin protein family (i.e., myelin basic protein, proteolipid lipoprotein, and myelin oligodendrocyte glycoprotein). Moreover, pathophysiological post-translational modifications of native Ags can trigger the immune system to generate autoantibodies escaping conventional diagnostic procedures [7]. Thus, autoantibodies against aberrant glycosylations have been hypothesized as diagnostic biomarkers in MS [8,9]. I...

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Lipid signalling in disease

Cited by 1,126 publications

References 148 publications

Molecular and cellular bases of chronic myeloid leukemia

Molecular and cellular bases of chronic myeloid leukemia

Genetics, physiology and perinatal influences in childhood obesity: view from the Chair

Natural Triterpene Glycosides for Antibody Recognition

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