1985
DOI: 10.1007/bf01907916
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Abstract: Dog experiments were performed to describe the time course of lipid peroxidation after various ischemic influences of the heart measured by formation of malondialdehyde (MDA), and the scavenger action determined by reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Experimental groups consisted of control dogs having intact hearts and dogs with acute ramus descendens anterior ligature (LAD) having ischemic areas through 15, 30, 45 minutes and 1, 2, 3, 24 hours. Heart tissue for biochemi… Show more

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Cited by 52 publications
(18 citation statements)
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“…However, there were several critical differences between these studies and the current study: (1) animals in the previous studies received repeated doses of ISO, as compared to the single dose administered in the current study, (2) measures of lipid peroxidation and oxidative stress were measured two or more days after the initial dose of ISO, as compared to 24 hours after the initial dose in the current study, (3) all 3 of these studies analysed homogenised myocardium, not circulating plasma. Interestingly, in support of our findings Röth, et al (37) demonstrated that although tissue levels of TBARS were elevated after cardiac injury induced by coronary artery ligation, they had returned to basal levels by 24 hours after ISO administration. Future studies should include an analysis of the effects of ethanolamine on tissue levels of lipid peroxidation indicators in ISO induced MI.…”
Section: Discussionsupporting
confidence: 91%
“…However, there were several critical differences between these studies and the current study: (1) animals in the previous studies received repeated doses of ISO, as compared to the single dose administered in the current study, (2) measures of lipid peroxidation and oxidative stress were measured two or more days after the initial dose of ISO, as compared to 24 hours after the initial dose in the current study, (3) all 3 of these studies analysed homogenised myocardium, not circulating plasma. Interestingly, in support of our findings Röth, et al (37) demonstrated that although tissue levels of TBARS were elevated after cardiac injury induced by coronary artery ligation, they had returned to basal levels by 24 hours after ISO administration. Future studies should include an analysis of the effects of ethanolamine on tissue levels of lipid peroxidation indicators in ISO induced MI.…”
Section: Discussionsupporting
confidence: 91%
“…In some studies, hearts were subjected to ischemia, but not reperfused (19)(20)(21). Other experiments performed in the model of the "oxygen paradox" also left the question open, since reoxygenation after a period of hypoxic perfusion resulted in increased cardiac levels of malonyldialdehyde (MDA),' an end-product oflipid peroxidation, in one study (22), but not in two others (23,24).…”
Section: Introductionmentioning
confidence: 99%
“…A reperfúziós terápia azonban paradox kö-vetkezményekkel jár, amelyet összefoglalóan reperfúziós károsodásnak nevezünk [2,3,4,5].…”
Section: A Szívizom Ischaemiás-reperfúziós Károsodásaiunclassified