Lipid Metabolism and Ferroptosis

Lee, Ji-Yoon; Kim, Won Kon; Bae, Kwang‐Hee; Lee, Sang Chul; Lee, Eun Woo

doi:10.3390/biology10030184

Cited by 169 publications

(169 citation statements)

References 104 publications

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“…Then, excessive iron might overpass the cells’ capabilities to maintain iron homeostasis. Our results are consistent with reports about cell death caused by iron treatment at concentrations similar to what we used in our experiments ( Baba et al., 2018 ; Chen et al., 2020 ; Lee et al., 2021 ).…”

Section: Discussionsupporting

confidence: 93%

Evaluating methods and protocols of ferritin-based magnetogenetics

2021

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Summary FeRIC (Ferritin iron Redistribution to Ion Channels) is a magnetogenetic technique that uses radiofrequency (RF) alternating magnetic fields to activate the transient receptor potential channels, TRPV1 and TRPV4, coupled to cellular ferritins. In cells expressing ferritin-tagged TRPV, RF stimulation increases the cytosolic Ca 2+ levels via a biochemical pathway. The interaction between RF and ferritin increases the free cytosolic iron levels that, in turn, trigger chemical reactions producing reactive oxygen species and oxidized lipids that activate the ferritin-tagged TRPV. In this pathway, it is expected that experimental factors that disturb the ferritin expression, the ferritin iron load, the TRPV functional expression, or the cellular redox state will impact the efficiency of RF in activating ferritin-tagged TRPV. Here, we examined several experimental factors that either enhance or abolish the RF control of ferritin-tagged TRPV. The findings may help optimize and establish reproducible magnetogenetic protocols.

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Section: Discussionsupporting

confidence: 93%

Evaluating methods and protocols of ferritin-based magnetogenetics

2021

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“…Furthermore, genes that regulate the production of ROS and lipid peroxides are also identified as biomarker for ferroptosis, such as LOX, NADPH oxidase 4 (NOX4), and ZFP36. The LOX family of enzymes is iron-dependent, the inhibition of which decreases accumulation of lipid peroxides and subsequently blocks ferroptosis [67]. Increased NOX4 impairs mitochondrial function, induces lipid peroxidation, and promotes ferroptosis [68].…”

Section: The Role Of Ferroptosis In Gastric Cancer (Gc)mentioning

confidence: 99%

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Liu

Xiao

2021

IJMS

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Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed in 2012, ferroptosis has attracted attention worldwide. Ferroptosis is involved in the progression of multiple diseases and could be a novel therapeutic target in the future. Recently, tremendous progress has been made regarding ferroptosis and gastrointestinal diseases, including intestinal ischemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), gastric cancer (GC), and colorectal cancer (CRC). In this review, we summarize the recent progress on ferroptosis and its interaction with gastrointestinal diseases. Understanding the role of ferroptosis in gastrointestinal disease pathogenesis could provide novel therapeutic targets for clinical treatment.

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“…SFA-enriched membranes affect the uptake of certain chemotherapeutics such as doxorubicin and promote the resistance to ionizing radiation ( 35 , 36 ). Since SFAs are more resistant to lipid peroxidation, metastatic PCa cells with SFA-enriched membranes would be most likely less susceptible to oxidative stress-induced ferroptosis, an iron-dependent form of cell death induced by reactive oxygen species (ROS)-mediated lipid peroxidation ( 37 ). Targeting de novo lipogenesis and the Lands cycle has recently been shown to induce ferroptosis in KRAS-mutant lung cancer ( 38 ) and we anticipate similar results in mCRPC.…”

Section: Lipid Metabolism Rewiring In Pca Development and Progressionmentioning

confidence: 99%

Prostate Cancer Progression: as a Matter of Fats

2021

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Advanced prostate cancer (PCa) represents the fifth cause of cancer death worldwide. Although survival has improved with second-generation androgen signaling and Parp inhibitors, the benefits are not long-lasting, and new therapeutic approaches are sorely needed. Lipids and their metabolism have recently reached the spotlight with accumulating evidence for their role as promoters of PCa development, progression, and metastasis. As a result, interest in targeting enzymes/transporters involved in lipid metabolism is rapidly growing. Moreover, the use of lipogenic signatures to predict prognosis and resistance to therapy has been recently explored with promising results. Despite the well-known association between obesity with PCa lethality, the underlying mechanistic role of diet/obesity-derived metabolites has only lately been unveiled. Furthermore, the role of lipids as energy source, building blocks, and signaling molecules in cancer cells has now been revisited and expanded in the context of the tumor microenvironment (TME), which is heavily influenced by the external environment and nutrient availability. Here, we describe how lipids, their enzymes, transporters, and modulators can promote PCa development and progression, and we emphasize the role of lipids in shaping TME. In a therapeutic perspective, we describe the ongoing efforts in targeting lipogenic hubs. Finally, we highlight studies supporting dietary modulation in the adjuvant setting with the purpose of achieving greater efficacy of the standard of care and of synthetic lethality. PCa progression is “a matter of fats”, and the more we understand about the role of lipids as key players in this process, the better we can develop approaches to counteract their tumor promoter activity while preserving their beneficial properties.

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Lipid Metabolism and Ferroptosis

Cited by 169 publications

References 104 publications

Evaluating methods and protocols of ferritin-based magnetogenetics

Evaluating methods and protocols of ferritin-based magnetogenetics

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Prostate Cancer Progression: as a Matter of Fats

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