volume 5, issue 4, P270-275 2013
DOI: 10.18632/aging.100548
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Sven Brandstädt, Kathrin Schmeisser, Kim Zarse, Michael Ristow

Abstract: Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established serum lipid-lowering drugs and ligands of the nuclear receptor PPARalpha in mammals, are capable of extending lifespan in a nematodal model organism for aging processes, the roundworm Caenorhabditi…

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