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Cited by 30 publications
(10 citation statements)
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References 7 publications
(10 reference statements)
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“…73,73 Other toxic lipids that have been associated with liver disease include diacylglycerols, yet they are understudied in the context of alcoholism. 82 Similarly, there is a growing literature linking endocannabinoid signaling and alcoholic liver disease, with our own lipidomic analysis reporting increased levels of anandamide in the alcohol-exposed liver. 47,83 A particular group of lipids that is pertinent to our own research are the retinoids; there is a longstanding literature linking chronic alcohol consumption with the depletion of hepatic retinoid content, but it remains unclear what the disease-related significance of this is.…”
Section: Recommendations For Future Studies In the Effect Of Alcohol mentioning
confidence: 79%
“…73,73 Other toxic lipids that have been associated with liver disease include diacylglycerols, yet they are understudied in the context of alcoholism. 82 Similarly, there is a growing literature linking endocannabinoid signaling and alcoholic liver disease, with our own lipidomic analysis reporting increased levels of anandamide in the alcohol-exposed liver. 47,83 A particular group of lipids that is pertinent to our own research are the retinoids; there is a longstanding literature linking chronic alcohol consumption with the depletion of hepatic retinoid content, but it remains unclear what the disease-related significance of this is.…”
Section: Recommendations For Future Studies In the Effect Of Alcohol mentioning
confidence: 79%
“…Furthermore, toll-like receptor 4 receptor signaling was not required for saturated fat-induced accumulation of ceramide, triglyceride, diacylglycerol, or impairment of hepatic insulin signaling. 27,28 Importantly, these results translate to humans in whom recent studies have found that increased hepatic diacylglycerol content 29,30 and protein kinase Cε activation, 30 and not ceramide content, are strongly associated with hepatic insulin resistance. Thus, the evidence to date suggests that regardless of how hepatic lipid accumulates, production of diacylglycerol is key and causes loss of insulin sensitivity.…”
Section: Arterioscler Thromb Vasc Biolmentioning
confidence: 84%
“…Thus, a combination of both tests might improve diagnostic performance to diagnose different stages of liver fibrosis in NAFLD, without having to resort to liver biopsy. 27,28 Studying which of these 2 mechanisms of lipid-induced insulin resistance is more important in vivo, these investigators found that saturated or unsaturated fat feeding in mice resulted in hepatic steatosis, increased intrahepatic diacylglycerol content, caused protein kinase Cε activation, and impaired insulin-stimulated insulin receptor substrate-2-associated phosphoinositide-3 kinase signaling. In contrast, neither of these diets led to an increase in hepatic ceramide content, thus dissociating ceramide content from hepatic insulin resistance in this rodent model.…”
Section: Arterioscler Thromb Vasc Biolmentioning
confidence: 99%
“…Thus, accumulation of ceramides and ceramide-mediated inhibition induce insulin resistance in the liver by inhibition of Akt phosphorylation. 79 Yet, FFA can cause activation of Akt phosphatase protein phosphatase 2A (PP2A). PP2A induce insulin resistance in the liver by dephosphorilation and inactivation of Akt that in turn acts to phosphorylate and inactivate the transcription factor Forkhead Box 01 (FOX-01), which induces transcription of the key enzimes of gluconeogenesis.…”
Section: Periportal Zone Perivenous Zonementioning
confidence: 99%